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Retinal
Vascular Geometry Predicts Incident Renal Dysfunction
in Young People With Type 1 Diabetes |
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Retinal venular geometry independently
predicted incident renal dysfunction in young people with
type 1 diabetes. These noninvasive retinal measures may
help to elucidate early mechanistic pathways for microvascular
complications (Diabetes Care) |
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Increased
prevalence of chronic kidney disease in patients with
Type 1 diabetes and non-alcoholic fatty liver |
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Our findings demonstrate that
ultrasound-diagnosed non-alcoholic fatty liver is associated
with a higher prevalence of chronic kidney disease in patients
with Type 1 diabetes, independently of several risk factors,
including the components of the metabolic syndrome (Diabetic
Medicine) |
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How
much does screening bring forward the diagnosis of type
2 diabetes and reduce complications? Twelve year follow-up
of the Ely cohort |
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Diabetes screening resulted
in cases being identified on average 3.3 years earlier,
a difference significantly shorter than previous estimates.
Earlier diagnosis did not appear to impact on health outcomes.
Further evidence is needed to justify the introduction
of population-based screening (Diabetologia) |
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Screening
for Gestational Diabetes Mellitus: Are the Criteria Proposed
by the International Association of Diabetes and Pregnancy
Study Groups Cost-Effective? |
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The IADPSG recommendation for
glucose screening in pregnancy is cost-effective. The model
is most sensitive to the likelihood of preventing future
diabetes in patients identified with GDM using postdelivery
counseling and intervention (Diabetes Care) |
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Proposed
new diagnostic criteria for gestational diabetes – a pause for thought? |
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New criteria for the diagnosis
of gestational diabetes promulgated by the International
Association of Diabetes and Pregnancy Study Groups (IADSPG)
have been adopted by a number of groups, including the
American Diabetes Association. These criteria will increase
two- to three-fold the number of women diagnosed with gestational
diabetes and have enormous resource implications (Diabetic
Medicine) |
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Integrated
Management of Type 2 Diabetes Mellitus and Depression
Treatment to Improve Medication Adherence: A Randomized
Controlled Trial |
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A randomized controlled trial
of a simple, brief intervention integrating treatment of
type 2 diabetes and depression was successful in improving
outcomes in primary care. An integrated approach to depression
and type 2 diabetes treatment may facilitate its deployment
in real-world practices with competing demands for limited
resources (Annals of Family Medicine) |
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Statin
Use and Risk of Diabetes Mellitus in Postmenopausal Women
in the Women's Health Initiative |
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Statin medication use in postmenopausal
women is associated with an increased risk for DM. This
may be a medication class effect. Further study by statin
type and dose may reveal varying risk levels for new-onset
DM in this population (Archives of Internal Medicine) |
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FRAX
underestimates fracture risk in patients with diabetes |
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FRAX underestimated observed
major osteoporotic and hip fracture risk in diabetics (adjusted
for competing mortality) but demonstrated good concordance
with observed fractures for nondiabetics. We conclude that
diabetes confers an increased risk of fracture that is
independent of FRAX derived with BMD. This suggests that
diabetes might be considered for inclusion in future iterations
of FRAX (Journal of Bone and Mineral Research) |
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Reversal
of type 1 diabetes via islet beta cell regeneration following
immune modulation by cord blood-derived multipotent stem
cells |
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Stem Cell Educator therapy is
safe, and in individuals with moderate or severe T1D, a
single treatment produces lasting improvement in metabolic
control. Initial results indicate Stem Cell Educator therapy
reverses autoimmunity and promotes regeneration of islet
beta cells (BMC Medicine) |
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Localisation
and composition of skeletal muscle diacylglycerol predicts
insulin resistance in humans |
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These data indicate that both
cellular localisation and composition of DAG influence
the relationship to insulin sensitivity. Our results suggest
that only saturated DAG in skeletal muscle membranes are
related to insulin resistance in humans (Diabetologia) |
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Acute
and chronic animal models for the evaluation of anti-diabetic
agents |
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The present review highlights
the various methods of inducing diabetes in experimental
animals in order to test the newer drugs for their anti-diabetic
potential - Provisional PDF (Cardiovascular Diabetology) |
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