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  Facilitating global development of biosimilars
  EMA to allow use of non-EEA authorised comparator in clinical studies (European Medicines Agency)
   
  Impact of Acute and Chronic Hyperglycemia on In-Hospital Outcomes of Patients With Acute Myocardial Infarction
  These results suggested that acute-HG, but not chronic-HG, was associated with adverse short-term outcomes after AMI. Paradoxically, in patients with acute-HG, chronic-HG might abate the adverse effects of acute-HG (American Journal of Cardiology)
   
  The validation of cardiovascular risk scores for patients with type 2 diabetes mellitus
  All 10 evaluated models had a comparable and moderate discriminative ability. The recalibrated, but not the original, prediction models provided accurate risk estimates. These models can assist clinicians in identifying type 2 diabetes patients who are at low or high risk of developing CVD (Heart)
   
  Initial Choice of Oral Glucose-Lowering Medication for Diabetes Mellitus
  Beginning treatment with metformin was associated with reduced subsequent treatment intensification, without differences in rates of hypoglycemia or other adverse clinical events (JAMA Internal Medicine)
   
  The mean platelet volume is significantly associated with higher glycated hemoglobin in a large population of unselected outpatients
  The results of our investigation, which is supposed to be the largest cohort study on unselected outpatients assessing the relationship between HbA1c and platelets number or size, indicate that elevated MPV is significantly associated with higher HbA1c levels and vice versa (Primary Care Diabetes)
   
  Complications and comorbidities of T2DM in adolescents: findings from the TODAY clinical trial
  The early manifestation of diabetes complications in youth-onset T2DM suggests that this group will be burdened with the tangible consequences of cardiovascular disease, nephropathy, and retinopathy in the third and fourth decades of life (Diabetes and Its Complications)
   
  Adipose Tissue, Muscle, and Function: Potential Mediators of Associations Between Body Weight and Mortality in Older Adults With Type 2 Diabetes
  Normal weight participants had elevated mortality risk compared with overweight participants. This paradoxical association was mediated in part by muscle size (Diabetes Care)
   
  Influence of the glycation gap on the diagnosis of type 2 diabetes
  The differences between HbA1C-based and FPG/OGTT-based diagnoses are largely due to the influence of the glycation gap, which may also influence the early stages of FPG/OGTT-defined diabetes (Acta Diabetologica)
   
  Serum ferritin, diabetes, diabetes control, and insulin resistance
  Elevated serum ferritin levels were associated with higher risks of diabetes, higher levels of HbA1c, and HOMA-IR independent of several confounders (Acta Diabetologica)
   
  A Very Low-Carbohydrate, Low–Saturated Fat Diet for Type 2 Diabetes Management: A Randomized Trial
  Both diets achieved substantial improvements for several clinical glycemic control and CVD risk markers. These improvements and reductions in GV and antiglycemic medication requirements were greatest with the LC compared with HC (Diabetes Care)
   
  Latent Autoimmune Diabetes in Adults With Low-Titer GAD Antibodies: Similar Disease Progression With Type 2 Diabetes: A Nationwide, Multicenter Prospective Study (LADA China Study 3)
  In selected LADA patients, initial GADA titers identified subjects with different degrees of persistent autoimmunity and disease progression. LADA patients with a low GADA titer had metabolic phenotypes and loss of ß-cell function similar to type 2 diabetic patients (Diabetes Care)
   
  New study to prevent type 1 diabetes planned for Diamyd Medical’s diabetes vaccine
  A new study is planned for the Diamyd® diabetes vaccine that will comprise 80 children with high risk of presenting with type 1 diabetes. The aim is to test whether the diabetes vaccine can prevent or delay the onset in the children (Diamyd)
   
  Mortality risk among sulfonylureas: a systematic review and network meta-analysis
  Gliclazide and glimepiride were associated with a lower risk of all-cause and cardiovascular-related mortality compared with glibenclamide. Clinicians should consider possible differences in risk of mortality when selecting a sulfonylurea (The Lancet Diabetes & Endocrinology)
   

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