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  Specificity and sensitivity of commercially available assays for glucagon-like peptide-1 (GLP-1): Implications for GLP-1 measurements in clinical studies
  The specificity and sensitivity of commercially available kits for analysis of GLP-1 levels varies considerably. This should be taken into account when selecting which assay to use and when comparing data from different studies (Diabetes, Obesity and Metabolism)
   
  Increased Risk of Severe Hypoglycemic Events with Increasing Frequency of Non-severe Hypoglycemic Events in Patients with Type 1 and Type 2 Diabetes
  A statistically significant association between non-severe hypoglycemic events and severe hypoglycemic events frequency was found in T1DM and T2DM. These data provide a clear rationale for the reduction of hypoglycemic events, regardless of severity, while striving for optimal glycemic control (Diabetes Therapy)
   
  Defects in ß-Cell Ca2+ Dynamics in Age-Induced Diabetes
  Our data suggest that ageing is associated with a progressive decline in ß-cell mitochondrial function that negatively impacts on the fine tuning of Ca2+ dynamics. This is conceptually important since it emphasizes that even relatively modest changes in ß-cell signal-transduction over time lead to compromised insulin release and a diabetic phenotype (Diabetes)
   
  Rectal Sensitivity in Diabetes Patients with Symptoms of Gastroparesis
  This study provided evidence of the generalized nature of diabetic autonomic neuropathy. Diabetes patients with signs and symptoms of upper GI dysfunction displayed reduced rectal sensitivity to heat and mechanical and electrical stimulation. Also, the heart rate variability was impaired. In a clinical setting, the presence of autonomic dysfunction could be regarded as a diffuse neuropathic complication (Journal of Diabetes Research)
   
  Characteristics of microbial drug resistance and its correlates in chronic diabetic foot ulcer infections
  Several multidrug resistant strains were observed among the samples tested and most of these strains had the ability to elicit moderate to high levels of biofilm. The weakened immune response in diabetic individuals and synergism among pathogenic microorganisms may be critical factors that may determine the delicate balance of wound healing process (Journal of Medical Microbiology)
   
  The association between retinal vascular geometry changes and diabetic retinopathy and their role in prediction of progression – an exploratory study
  The study findings suggest that RVG alterations can act as novel markers indicative of progression of DR severity and establishment of PDR. RVG may also have a potential predictive role in determining the risk of future retinopathy progression (BMC Ophthalmology)
   

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