Reviewed by Jim Young
Editors: Leonid Poretsky, Emilia Pauline Liao.
Consulting editor: Derek LeRoith
Published by Elsevier
This is the December 2013 edition in a series of quarterly publications by the Endocrinology and Metabolism Clinics of North America.
A concise, well structured and extensively referenced compilation of 13 reviews around the theme of acute and chronic complications of diabetes, it offers a collection of succinct discourses that will enthral during the three months between this and the next publication.
The reviews are replete with in-depth pathophysiology and practical treatment, and are suitable for both researchers and clinicians. As well as the recognised main sequelae of hypo / hyper glycaemia, retinopathy, neuropathy, nephropathy etc., they also deal with other associated complications such as: gastrointestinal, dermatological, dental, and reproductive effects.
The significant morbidity and reduced quality of life associated with these complications are stressed – not only in overt diabetes but also in prediabetes. Although published by the Endocrinology and Metabolism Clinics in USA the references also quote UK studies.
As one would expect, insulin resistance and hypertriglyceridemia are covered, along with both macro- and micro-vascular sequelae that result from the cascade of events triggered by reactive oxygen species (ROS) and RAGE that lead to cellular damage, inflammation and apoptosis.
The physical size of the book is pleasing and it is comfortable in the hand. Each review is of just the right length to provide both enlightenment and education. On average each of the 13 reviews is of 20 to 40 pages in length, so the imparting of knowledge is lean, succinct and brisk. But paradoxically each provides a leisurely read that enables the clinician to ensure a rounded update on pertinent areas in the field. The reviews emphasise why such an understanding is important because these associated complications are integral to the morbidity and mortality of diabetes.
I can recommend this book as an investment that will provide months of quiet, enjoyable contemplation of the fascinating interplay between the conditions associated with diabetes and pathophysiology of diabetes itself.
The book is also a prequel to the March 2014 publication of diabetes mellitus and associated conditions.
I am looking forward to the next quarterly publication.