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The
oral glucose tolerance test (OGTT) revisited |
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This review article rewinds the history of OGTT
and its recent advancements, and compares its power in detecting
early diabetes with that of fasting blood glucose alone (European
Journal of Internal Medicine) |
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Sequence
of Cellular Events in Pancreatic Islets Leading to Impaired Insulin
Secretion in Chronic Kidney Disease |
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The sequence of events that leads to these derangements
and to the impairment in insulin secretion during the evolution
of CRF has not been defined. This study examined this particular
issue by measuring the metabolic profiles of pancreatic islets
weekly during the evolution of CRF over a period of 6 weeks (Journal
of Renal Nutrition) |
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Hyperglycemia-induced
cerebral hematoma expansion is mediated by plasma kallikrein |
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We show that plasma kallikrein inhibits collagen-induced
platelet aggregation by binding collagen, a response enhanced by
elevated glucose concentration (Nature Medicine) |
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Scientists
discover new mechanism for controlling blood sugar level |
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The breakthrough was made in the University
of Leicester by a team led by Professor Andrew Tobin, Professor
of Cell Biology, who is a Wellcome Trust Senior Research Fellow
- Abstract in PNAS (University of Leicester) |
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Insulin
and Glucagon Regulate Pancreatic a-Cell Proliferation |
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Our results firmly establish that elevated levels
of glucagon and increased pancreatic a-cell number are two principle
factors in the progression of diabetes and, in fact, compounding
the problem (PLoS ONE) |
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Hyperglycemic
Myocardial Damage Is Mediated by Proinflammatory Cytokine: Macrophage
Migration Inhibitory Factor |
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Our findings indicate that hyperglycemia is
a causal factor for increased levels of pro-inflammatory cytokine
MIF which plays a role in the development of cardiomyopathy occurring
in patients with type 2 diabetes (PLoS ONE) |
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Impact
of Electronic Health Record Clinical Decision Support on Diabetes
Care: A Randomized Trial |
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EHR-based diabetes clinical decision support
significantly improved glucose control and some aspects of blood
pressure control in adults with type 2 diabetes (Annals of Family
Medicine) |
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Association
of change in daily step count over five years with insulin sensitivity
and adiposity: population based cohort study |
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In this large population based cohort, a higher
step activity at the end of a five year follow-up period than at
the beginning was associated with a lower body mass index, lower
waist to hip ratio, and higher HOMA insulin sensitivity at the
five year follow-up (BMJ) |
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Insulin
Degludec in Type 1 Diabetes |
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In this clinical exploratory phase 2 trial in
people with type 1 diabetes, IDeg is safe and well tolerated and
provides comparable glycemic control to IGlar at similar doses,
with reduced rates of hypoglycemia (Diabetes Care) |
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Technosphere
insulin: An inhaled mealtime insulin for the treatment of type
1 and type 2 diabetes mellitus |
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Although not yet FDA approved, Technosphere
insulin may be more costly than subcutaneous forms of insulin.
However, the option of a noninjectable form of insulin may be appealing
to patients who would be otherwise hesitant to initiate insulin
(Formulary) |
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Merck
to Acquire SmartCells, Inc |
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A definitive agreement under which Merck will
acquire SmartCells, a private company developing a glucose responsive insulin formulation for the
treatment of diabetes mellitus - December 2010 (Merck) |
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