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Retinal
Vascular Geometry Predicts Incident Renal Dysfunction in Young
People With Type 1 Diabetes |
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Retinal venular geometry independently predicted
incident renal dysfunction in young people with type 1 diabetes.
These noninvasive retinal measures may help to elucidate early
mechanistic pathways for microvascular complications (Diabetes
Care) |
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Increased
prevalence of chronic kidney disease in patients with Type 1
diabetes and non-alcoholic fatty liver |
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Our findings demonstrate that ultrasound-diagnosed
non-alcoholic fatty liver is associated with a higher prevalence
of chronic kidney disease in patients with Type 1 diabetes, independently
of several risk factors, including the components of the metabolic
syndrome (Diabetic Medicine) |
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How
much does screening bring forward the diagnosis of type 2 diabetes
and reduce complications? Twelve year follow-up of the Ely cohort |
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Diabetes screening resulted in cases being identified
on average 3.3 years earlier, a difference significantly shorter
than previous estimates. Earlier diagnosis did not appear to impact
on health outcomes. Further evidence is needed to justify the introduction
of population-based screening (Diabetologia) |
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Screening
for Gestational Diabetes Mellitus: Are the Criteria Proposed
by the International Association of Diabetes and Pregnancy Study
Groups Cost-Effective? |
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The IADPSG recommendation for glucose screening
in pregnancy is cost-effective. The model is most sensitive to
the likelihood of preventing future diabetes in patients identified
with GDM using postdelivery counseling and intervention (Diabetes
Care) |
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Proposed
new diagnostic criteria for gestational diabetes – a pause for thought? |
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New criteria for the diagnosis of gestational
diabetes promulgated by the International Association of Diabetes
and Pregnancy Study Groups (IADSPG) have been adopted by a number
of groups, including the American Diabetes Association. These criteria
will increase two- to three-fold the number of women diagnosed
with gestational diabetes and have enormous resource implications
(Diabetic Medicine) |
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Integrated
Management of Type 2 Diabetes Mellitus and Depression Treatment
to Improve Medication Adherence: A Randomized Controlled Trial |
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A randomized controlled trial of a simple, brief
intervention integrating treatment of type 2 diabetes and depression
was successful in improving outcomes in primary care. An integrated
approach to depression and type 2 diabetes treatment may facilitate
its deployment in real-world practices with competing demands for
limited resources (Annals of Family Medicine) |
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Statin
Use and Risk of Diabetes Mellitus in Postmenopausal Women in
the Women's Health Initiative |
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Statin medication use in postmenopausal women
is associated with an increased risk for DM. This may be a medication
class effect. Further study by statin type and dose may reveal
varying risk levels for new-onset DM in this population (Archives
of Internal Medicine) |
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FRAX
underestimates fracture risk in patients with diabetes |
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FRAX underestimated observed major osteoporotic
and hip fracture risk in diabetics (adjusted for competing mortality)
but demonstrated good concordance with observed fractures for nondiabetics.
We conclude that diabetes confers an increased risk of fracture
that is independent of FRAX derived with BMD. This suggests that
diabetes might be considered for inclusion in future iterations
of FRAX (Journal of Bone and Mineral Research) |
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Reversal
of type 1 diabetes via islet beta cell regeneration following
immune modulation by cord blood-derived multipotent stem cells |
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Stem Cell Educator therapy is safe, and in individuals
with moderate or severe T1D, a single treatment produces lasting
improvement in metabolic control. Initial results indicate Stem
Cell Educator therapy reverses autoimmunity and promotes regeneration
of islet beta cells (BMC Medicine) |
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Localisation
and composition of skeletal muscle diacylglycerol predicts insulin
resistance in humans |
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These data indicate that both cellular localisation
and composition of DAG influence the relationship to insulin sensitivity.
Our results suggest that only saturated DAG in skeletal muscle
membranes are related to insulin resistance in humans (Diabetologia) |
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Acute
and chronic animal models for the evaluation of anti-diabetic
agents |
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The present review highlights the various methods
of inducing diabetes in experimental animals in order to test the
newer drugs for their anti-diabetic potential - Provisional PDF (Cardiovascular Diabetology) |
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