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Long-term
use of thiazolidinediones and fractures in type 2 diabetes: a
meta-analysis |
| |
Long-term thiazolidinedione use doubles the
risk of fractures among women with type 2 diabetes, without a significant
increase in risk of fractures among men with type 2 diabetes. 14-page
PDF (CMAJ) |
| |
|
|
The
Antepartum Glucose Values that Predict Neonatal Macrosomia Differ
from those that Predict Postpartum Pre-diabetes or Diabetes:
Implications for the Diagnostic Criteria for Gestational Diabetes |
| |
On antepartum OGTT, the fasting glucose value
best predicts LGA risk, whereas post-load glucose values predict
postpartum pre-diabetes/diabetes. These relationships may have
implications for the glycemic thresholds that define obstetrical
and metabolic risk (Journal of Clinical Endocrinology & Metabolism) |
| |
|
|
The "Metabolic
Memory": Is More than Just Tight Glucose Control Necessary to Prevent Diabetic Complications? |
| |
The concept of a "metabolic
memory," that is of diabetic vascular stresses persisting after glucose normalization,
has been supported both in the laboratory and in the clinic and
in both type 1 and type 2 diabetes (Journal of Clinical Endocrinology & Metabolism) |
| |
|
|
Phenotypic
Type 2 Diabetes in Obese Youth: Insulin Sensitivity and Secretion
in Islet-cell Antibody Negative vs. Antibody Positive Patients |
| |
These important metabolic differences could
influence the natural history of hyperglycemia, insulin dependence
and clinical outcomes in these youth (Diabetes) |
| |
|
|
The
Effects of Intensive Therapy and Antecedent Hypoglycemia on Counterregulatory
Responses to Hypoglycemia in Type 2 Diabetes |
| |
Intensive oral combination therapy and antecedent
hypoglycemia both blunt physiologic defenses against subsequent
hypoglycemia in Type 2 DM (Diabetes) |
| |
|
|
UPDATE
1-Cerep in diabetes licensing deal with Sanofi |
| |
The deal relates to the NPY1 receptor antagonist,
which is in pre-clinical development for the treatment of type-2
diabetes (Reuters) |
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|
