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Projecting
the Future Diabetes Population Size and Related Costs for the
U.S. |
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Between 2009 and 2034, the number of people
with diagnosed and undiagnosed diabetes will increase from 23.7
million to 44.1 million (Diabetes Care) |
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Couch
kids: the nation's future |
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Four years on from our first report into childhood
obesity and children still aren’t getting the diet or exercise they need. 48-page PDF (British Heart Foundation) |
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Diabetics
Show Alarming Increase in Morbid Obesity |
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A Loyola University Health System study has
found that one out of five Type 2 diabetics is morbidly obese (Loyola
Medicine) |
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YKL-40
- an emerging biomarker in cardiovascular disease and diabetes |
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YKL-40 levels are elevated both in patients
with type 1 and type 2 diabetes, known to be at high risk for the
development of cardiovascular diseases (Cardiovascular Diabetology) |
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Insulin
Resistance in Adolescents with Type 1 Diabetes and Its Relationship
to Cardiovascular Function |
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T1D youth demonstrated IR, impaired functional
exercise capacity and cardiovascular dysfunction. The phenotype
of IR in T1D youth was unique, suggesting a pathophysiology that
is different from T2D, yet may adversely affect long-term cardiovascular
outcomes (Journal of Clinical Endocrinology & Metabolism) |
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Heritability
of insulin sensitivity and lipid profile depend on BMI: evidence
for gene–obesity interaction |
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Our results suggest that the expression of genes
influencing triacylglycerol and insulin sensitivity can vary as
a function of obesity status. The substantial increases in the
genetic contribution to the total variance in insulin sensitivity
and triacylglycerols at higher BMIs may prove extremely valuable
in the search for candidate genes (Diabetologia) |
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Treatment
disparities and effect on late mortality in patients with diabetes
presenting with acute myocardial infarction |
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Patients with diabetes have a higher risk than
non-diabetic patients of late mortality following an acute MI,
yet receive fewer guideline-recommended medications and early invasive
procedures (PubMed) |
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Pancreatic
Islet Autoantibodies as Predictors of Type 1 Diabetes in the
Diabetes Prevention Trial–Type 1 |
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The data indicate that the number of autoantibodies
is predictive of type 1 diabetes. However, mIAA is less predictive
of type 1 diabetes than other autoantibodies. Autoantibody number,
type of autoantibody, and autoantibody titer must be carefully
considered in planning prevention trials for type 1 diabetes (Diabetes
Care) |
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Rituximab,
B-Lymphocyte Depletion, and Preservation of Beta-Cell Function |
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A four-dose course of rituximab partially preserved
beta-cell function over a period of 1 year in patients with type
1 diabetes (NEJM) |
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In
Type 2 Diabetes, Mitochondrial Damage Kills Insulin-Producing
Cells |
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Over time, patients with type 2 diabetes lose
insulin-producing cells, a difficulty that aggravates their disease.
Researchers at Joslin Diabetes Center now have identified a mechanism
that triggers the problem, giving a chance to find targets for
drugs to protect these crucial cells (Joslin Diabetes Center) |
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Differing
effect of statins on insulin sensitivity in non-diabetics |
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Statins do not appear to demonstrate a 'class
effect' on IS in patients without diabetes. Differences between
individual statins likely exist that may partially explain the
findings of previously conducted meta-analyses examining the impact
of statins on the development of diabetes (PubMed) |
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Adolescents
on basal-bolus insulin can fast during Ramadan |
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We recommend that it is safe for adolescents
with diabetes to fast during Ramadan as long as they reduce their
basal insulin by this amount and continue to monitor their blood
glucose regularly (Pediatric Diabetes) |
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Colesevelam
HCl Improves Fasting Plasma Glucose and Lipid Levels in Patients
with Prediabetes |
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In patients with hyperlipidemia and prediabetes,
colesevelam HCl improved glycemic control and the lipid profile
(Postgraduate Medicine) |
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Incremental
Value of Continuous Glucose Monitoring When Starting Pump Therapy
in Patients With Poorly Controlled Type 1 Diabetes |
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CGM-enabled insulin pump therapy improves glycemia
more than conventional pump therapy during the first 6 months of
pump use in patients who wear CGM sensors at least 70% of the time
(Diabetes Care) |
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NCD
alliance presses Commonwealth governments to act |
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The world’s three leading
federations in cancer, diabetes and heart disease have issued a joint call to action asking Commonwealth heads of government to address the growing emergency of non-communicable
diseases (IDF) |
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