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Mortality
trends in subjects with and without diabetes during 33 years
of follow up |
| |
Diabetic subjects had less mortality rate reduction
during follow up than non-diabetic subjects. However the excess
mortality risk for diabetic subjects was smaller than found in
other studies (Diabetes Care) |
| |
|
|
Insulin
use and increased risk of mortality in type 2 diabetes: a cohort
study |
| |
We observed a significant and graded association
between mortality risk and insulin exposure level in an inception
cohort of patients with type 2 diabetes that persisted despite
multivariable adjustment (Diabetes, Obesity and Metabolism) |
| |
|
|
Type-two
diabetes limb amputations rise dramatically |
| |
The number of people in England having a limb
amputated because of type-two diabetes has risen dramatically,
a study has shown (BBC) |
| |
|
|
Novo
Nordisk Says to Get Feedback on Diabetes Drug in USA Within Weeks |
| |
Danish pharma major Novo Nordisk said on December
30th that it expects formal feedback from the US Food and Drug
Administration (FDA) regarding the new drug application (NDA) for
its diabetes drug candidateliraglutide within weeks (Therapeutics
Daily) |
| |
|
|
Diabetes-related
ESRD incidence in U.S. population continues to decline |
| |
The incidence of diabetes-related end-stage
renal disease has decreased in all age groups, from 343.2 per 100,000
people with diabetes in 1996 to 197.7 per 100,000 people with diabetes
in 2006 (Endocrine Today) |
| |
|
|
Adaptation
of colonic fermentation and glucagon-like peptide-1 secretion
with increased wheat fibre intake for 1 year in hyperinsulinaemic
human subjects |
| |
High cereal fibre intake is associated with
reduced risk for type 2 diabetes, but wheat fibre had little or
no effect on glycaemic control or oral glucose tolerance in clinical
trials lasting 4–12 weeks (British Journal of Nutrition) |
| |
|
|
Use
of the Site of Subcutaneous Insulin Administration for the Measurement
of Glucose in Patients with Type 1 Diabetes |
| |
Our data suggest that estimation of plasma glucose
concentrations from the glucose levels directly observed at the
site of subcutaneous insulin infusion is feasible and its quality
is comparable to that of estimating plasma glucose concentrations
from glucose levels measured in insulin-unexposed subcutaneous
tissue (Diabetes Care) |
| |
|
|
New
Insights into Hyperglycemia-induced Molecular Changes in Microvascular
Cell |
| |
In this review, we describe changes involving
basement membrane thickening, tissue remodeling, gap junctions,
inflammation, cytokines, and transcription factors, and their effects
on the pathogenesis of diabetic microvascular complications (Journal
of Dental Research via PubMed) |
| |
|
|
HDL
not as protective in people with type 2 diabetes |
| |
DL from people with type 2 diabetes and metabolic
syndrome had significantly impaired endothelial-protective effects
compared with HDL from otherwise healthy people, according to data
recently published in Circulation (Endocrine Today) |
| |
|
|
Telomere
length predicts all-cause mortality in patients with type 1 diabetes |
| |
In patients with type 1 diabetes we found no
differences in telomere length between patients with or without
diabetic nephropathy. We also found that telomere length was associated
with all-cause mortality; however, confirmative studies are needed
to verify our findings (Diabetologia) |
| |
|
|
The
global diabetes epidemic as a consequence of lifestyle-induced
low-grade inflammation |
| |
Chronic low-grade inflammation will eventually
lead to overt diabetes if counter-regulatory circuits to inflammation
and metabolic stress are compromised because of a genetic and/or
epigenetic predisposition (Diabetologia) |
| |
|
