Glycosmedia. An international diabetes news service from the UK

Body mass index has no effect on rate of progression of chronic kidney disease in subjects with type 2 diabetes mellitus

Tue, 15 May 2012 21:24:26 +0100

In 229 adults who met the inclusion criteria, after a mean follow-up period of 31 months, linear regression analysis showed no relationship between eGFR and BMI (Journal of Nephrology)

State of the Nation 2012

Mon, 14 May 2012 23:11:08 +0100

We are in a state of crisis. Ministers and the NHS need to recognise this, to prioritise prevention of diabetes and its complications - Download (Diabetes UK)

A Microalbuminuria Threshold to Predict the Risk for the Development of Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients

Fri, 11 May 2012 17:45:04 +0100

These data suggest that an MA threshold can predict the risk for the development of DR in type 2 diabetes mellitus, although it is still within the traditionally established normal rang (PLoS ONE)

Insulin-Like Growth Factor Axis and Risk of Type 2 Diabetes in Women

Fri, 11 May 2012 17:44:44 +0100

This prospective study found strong associations of incident diabetes with baseline levels of three IGFBPs and free IGF-I, consistent with hypotheses that the IGF axis might influence diabetes risk (Diabetes)

Impaired incretin effect and fasting hyperglucagonaemia characterizing type 2 diabetic subjects are early signs of dysmetabolism in obesity

Fri, 11 May 2012 17:44:22 +0100

Our findings suggest that reduced incretin effect and fasting hyperglucagonaemia constitute very early steps in the pathophysiology of T2DM detectable even in obese people who despite their insulin-resistant state have NGT (Diabetes, Obesity and Metabolism)

CureXcell™ - video

Thu, 10 May 2012 12:52:11 +0100

MacroCure currently manufactures and markets its lead product, CureXcell™, in Israel for hard-to-heal wound treatment. The cell therapy company has its regulatory strategy in place for market approval in North America and Europe. CureXcell™, a cell based therapy for hard to heal wounds, to restore the wound healing process (You Tube video from MacroCure)

Diabetes Alters Intracellular Calcium Transients in Cardiac Endothelial Cells

Thu, 10 May 2012 11:43:55 +0100

The results of this study demonstrate that diabetes results in significantly altered [Ca2+]i transients via disruptions in SERCA-mediated Ca2+ sequestration and NCX-mediated Ca2+ efflux mechanisms. To the best of our knowledge, this is the first report of the effect of diabetes on intracellular Ca2+ regulatory mechanisms and overall Ca2+ homeostasis in the cardiac endothelium (PLoS ONE)

RESTORE extension study in DME patients

Thu, 10 May 2012 11:43:39 +0100

New data among 200 Lucentis® abstracts at ARVO show low number of injections with Novartis drug required to achieve and maintain vision gains over 3 years in AMD and DME patients (Novartis)

Whole Genome Sequencing in Type 2 Diabetes Genetic Study

Wed, 9 May 2012 18:02:53 +0100

Complete Genomics announced today that it has sequenced the genomes of 600 individuals from 20 Mexican-American families from San Antonio in what is thought to be the largest whole genome sequencing family study conducted to date and the first such study of its kind in a Latino population (Complete Genomics)

Intravitreal bevacizumab for diabetic macular oedema

Wed, 9 May 2012 18:02:31 +0100

Results of a systematic review of randomised controlled trials of intravitreal bevacizumab for the treatment of diabetic macular oedema (Canadian Agency for Drugs and Technologies in Health)

Obesity - working with local communities: draft guidance consultation

Wed, 9 May 2012 18:02:09 +0100

Registered stakeholders for this guidance are invited to comment on the provisional recommendations via this website (NICE)

The Application of the Diabetes Prevention Trial–Type 1 Risk Score (DPTRS) for Identifying a Preclinical State of Type 1 Diabetes

Wed, 9 May 2012 18:01:50 +0100

A DPTRS threshold of 9.00 identifies individuals who are very highly likely to progress to the conventional diagnosis of T1D within 2 years and, thus, are essentially in a preclinical diabetic state (Diabetes Care)