Blood pressure below 130/80 mm Hg was not associated with reduced risk of all cause mortality in patients with newly diagnosed diabetes, with or without known cardiovascular disease. Low blood pressure, particularly below 110/75 mm Hg, was associated with an increased risk for poor outcomes (British Medical Journal)
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In patients with Type 2 diabetes, well controlled with metformin monotherapy, addition of liraglutide improves several cardiovascular risk markers beyond glycaemic control (Diabetic Medicine)
New data for Lucentis® (ranibizumab), the only anti-VEGF therapy licensed across three ocular indications, show that individualized treatment with Lucentis provides sustained improvement in vision with a low number of injections. It is estimated that over 80% of visual impairment is preventable when due to conditions such as … diabetic macular edema (DME)
This study shows that diabetes patients participating in a web-based intensive monitoring system differ from a reference population. The observed differences might lead to an underestimation of adverse drug reactions (ADRs), but it is not clear whether this would also influence the type or time-course of the reported ADRs (Pharmacoepidemiology and Drug Safety)
Genotyping at multiple susceptibility loci in children from affected families can identify neonates with sufficient genetic risk of type 1 diabetes to be considered for early intervention (Genes and Immunity)
Women with diabetes had an increased prevalence of advanced DKD and common DKD risk factors compared to men and these disparities were most prominent amongst the elderly (American Journal of Nephrology)
In addition to mean HbA1c values, HbA1c variability, even measured as early as 2 years, is independently associated with the development of microalbuminuria in patients with type 2 diabetes (Diabetologia)
App serves as a teaching tool and can provide guidance for treatment with Lilly Glucagon for Injection (rDNA origin) during severe hypoglycemic events (Lilly)
This review calls attention to the lack in knowledge, understanding, and general awareness of medical and scientific societies on how to treat and prevent diabetic vascular disease in women. Despite the evident gender-associated differences in the phathophysiology of CVD and the higher incidence of vascular disease in diabetic women, the trends and guidelines are dominated by data obtained in men (Experimental Diabetes Research)
Diabetes UK Cymru has joined forces with the Stoke Association, Public Health Wales, Community Pharmacy Wales and all seven health boards to launch a major public health campaign in September (Diabetes UK Cymru )
A big thank you to Diabetology for sponsoring Glycosmedia
Their logo (along with Lilly’s) will be joining Abbott on our App shortly (next update).
Glycosmedia is a diabetes clinical review that displays a selection of the very latest research papers, reports, news and information about diabetes
Insulin resistance is a prominent feature of lean patients with type 1 diabetes mellitus, despite long term and stable treatment with CSII. Insulin resistance in type 1 diabetes involves both lipolysis, hepatic and peripheral glucose metabolism (Diabetes/Metabolism Research and Reviews)
Education and counselling by community pharmacists can result in favourable improvements to the cardiovascular risk profile of patients with Type 2 diabetes (Diabetic Medicine)
Compared with practices with no nurse(s) employed, the quality of diabetes management was generally higher in terms of that HbA1c was measured according to the guidelines in a larger proportion of the diabetes population and the proportion of patients with an HbA1c level =8% was lower in practices with well-implemented nurse-led type 2 diabetes consultations (Primary Care Diabetes)
Children with T1DM have lower 25OHD than controls, even in an environment of abundant sunlight. Whether low vitamin D is a risk factor or consequence of T1DM is unknown (Pediatric Diabetes)
A bihormonal bionic endocrine pancreas achieved excellent glycemic control with minimal hypoglycemia over the course of 2 days of continuous use despite high-carbohydrate meals and exercise. A trial testing a wearable version of the system under free-living conditions is justified (Diabetes Care)
A recent publication reported the identification of another ten genes which may predispose to type 2 diabetes (T2DM), bringing the current total to around fifty. However, the impact of these genetic studies from a clinical perspective remains minimal. Forty years after the discovery of the first genes involved in diabetes susceptibility, should we be querying the value of expensive ‘factory floor’ genetics?
Parents report moderate willingness to enroll children in T1DCTs. Willingness is diminished by common trial methodologies. Although most parents recalled receiving trial-related information, significantly fewer recalled being asked to participate. Efforts to optimize effective communication around identified areas of parental concern may increase T1DCT participation (PLoS ONE)
The current study will undertake various means to deal with the challenges posed by recent investigations, including comparison to a large population of individuals without diabetes in a nationwide population, and accessing a large number of potentially confounding factors and data on cancer screening BMC Cancer)