Higher osteopontin concentrations were associated with an increased CVD risk in type 2 diabetes patients. No consistent associations were found for the other five bone markers and risk of CVD in type 2 diabetes patients (Cardiovascular Diabetology)
Diabetes News
Tag: bone
Review article: effects of type 2 diabetes therapies on bone metabolism
Patients with T2DM have an increased risk of fragility fractures, which was not predictable by BMD measurements. This higher risk is probably multifactorial, and antidiabetic therapies may have an impact on bone metabolism (Diabetology & Metabolic Syndrome)
Sweet Bones: The Pathogenesis of Bone Alteration in Diabetes
The major deficits appear to be related to a deficit in mineralized surface area, a decrement in the rate of mineral apposition, deceased osteoid surface, depressed osteoblast activity, and decreased numbers of osteoclasts due to abnormal insulin signaling pathway (Journal of Diabetes Research)
Bone Microarchitecture in Men and Women with Diabetes: The Importance of Cortical Porosity
High-resolution peripheral quantitative computed tomography (HR-pQCT) captures novel aspects of bone geometry, volumetric bone mineral density and offers the ability to measure bone microarchitecture (Calcified Tissue International)
Effects of diabetes drugs on the skeleton
Type 2 diabetes is associated with increased fracture risk and the mechanisms underlying the detrimental effects of diabetes on skeletal health are only partially understood. Antidiabetic drugs are indispensable for glycemic control in most type 2 diabetics, however, they may, at least in part, modulate fracture risk in exposed patients (Bone)
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