We demonstrate signs of transient, prediagnostic evidence of autoimmune activity in patients later diagnosed and classified as having type 2 diabetes. Compared with other participants with type 2 diabetes, this subgroup had earlier onset of diabetes and may have lower β-cell function with possible clinical implications (Diabetes Care)
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Tag: lada
Lower mortality and cardiovascular event rates in patients with latent autoimmune diabetes in adults (LADA) as compared with type 2 diabetes and insulin deficient diabetes
LADA seems to be associated with lower mortality and lower risk of cardiovascular events, compared with both T2D and IDD (Diabetes Research and Clinical Practice)
Relative contribution of type 1 and type 2 diabetes loci to the genetic etiology of adult-onset, non-insulin-requiring autoimmune diabetes
LADA is genetically closer to T1D than T2D, although the genetic load of T1D risk alleles is less than childhood-onset T1D, particularly at the major histocompatibility complex region, potentially accounting for the later disease onset. Our results show that the genetic spectrum of T1D extends into adult-onset diabetes, where it can clinically masquerade as T2D (BMC Medicine)
Persons with latent autoimmune diabetes in adults express higher dipeptidyl peptidase-4 activity compared to persons with type 2 and type 1 diabetes
Persons with LADA express higher DPP-4 activity compared to persons with both type 1 and type 2 diabetes. The possible patophysiological role of DPP-4 in the LADA pathogenesis needs to be further evaluated (Diabetes Research and Clinical Practice)
Insulin secretion in patients with latent autoimmune diabetes (LADA): half way between type 1 and type 2 diabetes: action LADA 9
The present study shows that the magnitude of stimulated insulin secretion in LADA is intermediate between that of type 1 and type 2 diabetes mellitus (BMC Endocrine Disorders)
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