In patients with type 2 diabetes and cardiovascular disease, albiglutide was superior to placebo with respect to major adverse cardiovascular events. Evidence-based glucagon-like peptide 1 receptor agonists should therefore be considered as part of a comprehensive strategy to reduce the risk of cardiovascular events in patients with type 2 diabetes (The Lancet)
Diabetes News
Tag: Type 2 Diabetes
Sex- and age-related differences of metabolic parameters in impaired glucose metabolism and type 2 diabetes compared to normal glucose tolerance
IGM did not reveal relevant changes of insulin resistance with age, but early phase insulin release deteriorated, with higher change in women. T2DM men featured age-related deterioration of glucose metabolism. In women, sex advantage seen in NGT vanished in T2DM, since glucose metabolism was overall not different than in men, both young and elderly (Diabetes Research and Clinical Practice)
Non-albuminuric renal impairment is a strong predictor of mortality in individuals with type 2 diabetes
The Renal Insufficiency And Cardiovascular Events (RIACE) Italian multicentre study (Diabetologia)
Early vascular parameters in the micro- and macrocirculation in type 2 diabetes
These data suggest that at similar blood pressure capillary rarefaction in the retinal circulation (ICD), decreased eGFR in the renal circulation and increased central pulse pressure (cPP) of large arteries are earlier detectable than other vascular remodeling parameters of the micro- (WLR, RCF, UACR) and macrocirculation (cSBP) in patients with T2DM (Cardiovascular Diabetology)
Cognitive functioning and structural brain abnormalities in people with Type 2 diabetes mellitus
In people with long‐standing, less strictly controlled Type 2 diabetes, white matter hyperintensities volumes were associated with decreased processing speed. This suggests that cerebral small vessel disease is an underlying disease mechanism of cognitive dysfunction in these individuals (Diabetic Medicine)
Five-Year Predictors of Insulin Initiation in People with Type 2 Diabetes under Real-Life Conditions
In conclusion, even if patients with T2DM are characterized by different rates of disease progression and the clinical presentation of the disease could lead to insulin treatment initiation per se, the analysis of the collected data allows us to partly respond to typical patient’s question “will I need insulin?,” which originated in this paper (Journal of Diabetes Research)
A Prospective Cohort Study on the Management of Young Patients with Newly Diagnosed Type 2 Diabetes Using Mobile Medical Applications
A mobile medical app is helpful to young patients with newly diagnosed T2DM for monitoring their blood glucose level and improving their blood glucose control to meet the standard (Diabetes Therapy)
Diabetes and Diet: A Patient and Dietitian’s Perspective
This article has been co-authored by a patient with type 2 diabetes and a specialist dietitian. Here they discuss the patient’s experience and difficulties with controlling weight and strategies that can help a patient in this situation (Diabetes Therapy)
Metabolic Control in Type 1 Diabetes: Is Adjunctive Therapy the Way Forward?
Restricting therapy for T1DM to insulin replacement is perhaps an over-simplistic approach, and we focus in this work on reviewing the role of adjuvant therapy in this population (Diabetes Therapy)
Midlife development of type 2 diabetes and hypertension in women by history of hypertensive disorders of pregnancy
Women with history of HDP are not only at higher risk of cardiometabolic disease during their reproductive years, but HDP is also associated with midlife T2D development above and beyond established risk factors (Cardiovascular Diabetology)
Risk of type 2 diabetes and cardiovascular disease in an incident cohort of people with psoriatic arthritis: a population-based cohort study
The development of T2D in an incident population of PsA is significantly higher than in psoriasis alone or in a general population, whereas the increased risk of cardiovascular disease in PsA and psoriasis is similar (Rheumatology)
Longitudinal relationship between retinal diabetic neurodegeneration and progression of diabetic retinopathy in patients with type 2 diabetes
Progressive loss of mGCIPL is an independent risk factor for progression in early-stage DR. Further assessment of autonomic and peripheral nerve functions can increase sensitivity in predicting aggravation of DR in patients with T2DM (American Journal of Ophthalmology)
Combination Therapy with GLP-1 Receptor Agonists and SGLT-2 Inhibitors in Older Patients with Type 2 Diabetes: a Real-World Evidence Study
This study’s findings provide evidence of clinically-meaningful reductions in HbA1c, body weight, and SBP in older T2D patients on combined regimens. The dropout and hypoglycemia rate were minimal and treatment was tolerated well (Canadian Journal of Diabetes)
Living with Type 2 Diabetes: Patient Commentary in Response to the Paper ‘SGLT2 Inhibitors in Type 2 Diabetes Management: Key Evidence and Implications for Clinical Practice’
This article, co-authored by a patient living with type 2 diabetes and a diabetes specialist physician, discusses the patient’s experience of living with type 2 diabetes, including their experience of diagnosis and self-management, education and adoption of SGLT2 inhibitors to treat the disease. The physician discusses the therapeutic challenges of SGLT2 inhibitors and the importance of education (Diabetes Therapy)
Medicines for Treatment Intensification in Type 2 Diabetes and Type of Insulin in Type 1 and Type 2 Diabetes in Low-Resource Settings
Synopsis of the World Health Organization Guidelines on Second- and Third-Line Medicines and Type of Insulin for the Control of Blood Glucose Levels in Nonpregnant Adults With Diabetes Mellitus (Annals of Internal Medicine)
Metformin is the key factor for elevated plasma GDF‐15 levels in type 2 diabetes: a nested, case‐control study
The relatively higher GDF‐15 bioavailability might contribute to explain the protective cardiovascular effects of metformin (Diabetes, Obesity and Metabolism)
Effectiveness of educational intervention based on psychological factors on achieving health outcomes in patients with type 2 diabetes
The results of this study shed light on the importance of the effectiveness of psychological factors on achieving health outcomes in patients with type 2 diabetes (T2D). Moreover, a new combination of diet-related psychological factors in patients with diabetes was introduced in the present study (Diabetology & Metabolic Syndrome)
Ethnicity-specific association of BMI levels at diagnosis of type 2 diabetes with cardiovascular disease and all-cause mortality risk
This study suggests a paradoxical association of BMI with cardiovascular and mortality risks in different ethnic groups, which may partially be driven by different cardiovascular and glycaemic risk profiles at diagnosis (Acta Diabetologica)
Expectations and fear of diabetes-related long-term complications in people with type 2 diabetes at primary care level
Prevalence of diabetes-related long-term complications was overestimated in people with diabetes type 2. Approximately one third of the participants showed even great fear. Patient expectation and fear about diabetes-associated complications did not correspondent with data on clinical reality (Acta Diabetologica)
Efficacy and Safety of Initial Combination Therapy in Treatment-Naïve Type 2 Diabetes Patients
Compared with monotherapy, all initial combination therapies resulted in significant HbA1c reductions. Compared with metformin monotherapy, initial combination therapies with DPP-4 inhibitors plus metformin, sodium/glucose cotransporter 2 inhibitors and metformin, respectively, were associated with similar risks of hypoglycemia, but initial combination therapies with sulfonylurea plus metformin, thiazolidinedione and metformin, respectively, were associated with higher risks of hypoglycemia (Diabetes Therapy)
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