In the 1st year of life, weight gain in infants born to women with GDM is associated with insulin resistance, unlike in their peers (Diabetes Care)
Archives for June 2012
Contemporary transition practices may help prevent gaps between pediatric and adult care but do not appear to promote improvements in A1C. More robust preparation strategies and handoffs between pediatric and adult care should be evaluated (Diabetes Care)
The quality of most guidelines concerning the management of diabetes during pregnancy needs to be improved. A more systematic approach in the development of these guidelines, more attention for updating procedures and piloting of the guidelines and involvement of target users and patients is recommended (BMC Pregnancy and Childbirth)
Screening for diabetes is not associated with long-term harms at the population level. However, screening has limited long-term impact on those testing negative; benefits may largely be restricted to those whose diabetes is detected early through screening (Diabetic Medicine)
This meta-analysis indicates a significant inverse relation of serum 25OHD and the incidence of GDM. However, it remains unclear whether this association is causal due to the observational study design of the studies (European Journal of Internal Medicine)
We identified two T2D susceptibility loci that modulate insulin requirements in T1D patients. Our results are consistent with the association of lower insulin secretion with higher insulin sensitivity. To explain the continuation of this correlation after ß-cell destruction, we hypothesize an epigenetic mechanism that alters insulin responsiveness in T1D patients based on ß-cell function in early life (Hormone Research in Paediatrics)
Increased inflammation, expression of MMP-9, PTP1B, and aberrant growth factor levels are the main factors associated with failure to heal DFUs. Targeting these factors may prove helpful in the management of DFUs (Diabetes)
The glucagon response to hypoglycemia in adolescents with type 1 diabetes is influenced by the duration of diabetes and can be lost early in the course of the disease (Diabetes Care)
In this review, we offer a critical appraisal of the events linking the participation of the proximal tubular epithelial cell (PTEC) to the pathogenesis of DN, which we believe may be collectively termed diabetic tubulopathy (Nephrology Dialysis Transplantation)
Diabetes Apps, are they a happy happenstance – where technology wins over pathology – or a counterproductive hypertrophy of data? This article will open this Pandora’s Box.
The number of Apps (application software) for smart phones has expanded exponentially in recent times: with hardware add-ons that enable glucose monitoring and the recording of data; the storage of data for patient self-care or for upload to the “Cloud” for access by their healthcare professionals. There are Apps that offer advice about diet, lifestyle, and disease management.
But are these Apps of real benefit to the patient and do they augment or retard physician interventions?
Diabetes and climate change are two urgent challenges in the 21st century. IDF has produced a pioneering policy report that establishes both the interconnections between these global risks and the opportunity to combat them together (International Diabetes Federation)
The REasons for Geographic And Racial Differences in Stroke (REGARDS) study – In this population-based study, almost one in four individuals with diabetes reported stroke symptoms, which suggests that screening for stroke symptoms in diabetes may be warranted (Diabetes Care)
This meta-analysis of 8859 patients with diabetes mellitus shows favourable effects on lipids with the three statins studied, in line with results for the overall VOYAGER population. The importance of using an effective statin at an effective dose to reach treatment goals for such high-risk patients is evident (Nutrition, Metabolism & Cardiovascular Diseases)
Despite improvements in insulin therapy, T1D patients still suffer many reproductive problems that warrant specific diagnoses and therapeutic management. Similar to other states of metabolic stress, T1D represents a challenge to the correct functioning of the reproductive axis (Human Reproduction Update)
Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
GPs are being urged to ramp up diabetes treatment within just three months if they do not reach their glycaemic goals on metformin alone, under a radical update of guidelines issued by European and American diabetes societies (Pulse)
Topical clonidine gel significantly reduces the level of foot pain in painful diabetic neuropathy subjects with functional (and possibly sensitized) nociceptors in the affected skin as revealed by testing with topical capsaicin. Screening for cutaneous nociceptor function may help distinguish candidates for topical therapy for neuropathic pain (International Association for the Study of Pain)
Our results suggest that postprandial insulin rather than glucose accounts for postprandial platelet activation in T2DM patients (Diabetes)
The association between plasma glucose levels and CVD risk is mainly explained by insulin resistance, which raises the question of whether glucose lowering per se without changes in the processes that underlie hyperglycemia should be the sole clinical paradigm in the treatment of type 2 diabetes or its prevention (PLoS ONE)