A Phase 2a clinical trial for ORMD-0801 oral insulin capsule for the treatment of type 2 diabetes met all primary and secondary endpoints (Oramed)
Archives for January 2014
These data indicate that several strategies prevent T2DM, making it possible to make a choice for the individual subject (Diabetes, Obesity and Metabolism)
Management strategies must be tailored to the individual with their age and life circumstances taken into account. Provision of education for patients and their support network is crucial, and should be a priority – includes supplementary audio (The Lancet Diabetes & Endocrinology)
Wentworth J. Hensman T. et al. Diabetologia. Doi: 10.1007/s00125-013-3129-0
Although the conclusion of this research is not earth shattering, it is nice that a hypothesis which has reasonable credibility is actually proven. Obese people with impaired fasting glucose who are subjected to a laparoscopic adjustable gastric banding (LAGB) procedure leading to a loss of weight, significantly reduce their chances of subsequently developing diabetes. Even better, the follow up period was at least 4 years, giving the research and conclusions more authority. The results in themselves will not come as a great surprise to many of us and also provides more ammunition for the supporters of bariatric surgery, as this is proof that it can offer some form prevention of diabetes, in this group. It’s also a good argument to justify the cost of bariatric surgery. But it is also a drastic option and may be a difficult to access service in some areas of the country. Perhaps this research which highlights the impact of weight loss could be extrapolated to other interventions which may also lead to weight loss such as intensive dietetic support services and maybe can be offered to even more people.
This study reveals a successful uptake and communication of a professional message to a wider audience through Twitter and YouTube among social media-naïve HCPs studying for a postgraduate diploma in diabetes. Despite initial apprehension, HCPs felt confident in using social media to convey the message with continuing use of social media beyond the confines of the course (Practical Diabetes)
This study is thought to be the first of its kind to consult with children, young people and parents to find out about their experiences of type 1 diabetes care provision. The research findings add to the current evidence base by highlighting the disparities in care, the urgent need for change in the way services are delivered and the involvement of service users in this process (Practical Diabetes)
Online, telephone-based care management, and Web training for diabetes patients with elevated A1c were each associated with a substantial improvement in A1c over a 1-year period. Internet access and training alone may be as effective as care management in patients with poorly controlled diabetes (Diabetes Technology and Therapeutics)
Oral glucose tolerance test does differentiate the great heterogeneity in metabolic disorders of patients with FPG 100–125 mg/dL. Furthermore, PG% can expand the diagnostic power of OGTT in the is-IFG range by distinguishing metabolic phenotypes very likely to herald different clinical risks (Journal of Diabetes Investigation)
Preoperative characteristics determine T2D remission rates after BS to different extents. The use of statistical models may help clinicians reliably predict T2D remission rates after BS (Journal of Diabetes)
Genetic variants associated with low plasma 25(OH)D concentrations are associated with type 2 diabetes and low plasma 25(OH)D concentrations might be a modest mediator between obesity and increased risk of diabetes.However, as findings for DHCR7 were not statistically significant, our results require independent confirmation (The Lancet Diabetes & Endocrinology)
Circadian variations in glucose homeostasis were assessed on relevant parameters, and a significant improvement was achieved by including a circadian rhythm on the endogenous glucose production in the model. The extended model is a useful tool for clinical trial simulation and for elucidating the effect profile of new insulin products (Journal of Clinical Pharmacology)
This is the first study to report a significant association between statin use and diminished amputation risk among patients with diabetes (Journal of Vascular Surgery)
A new year and a chance to reassess the state of diabetes care. This was the purpose of the ‘State of the Nation’ report from Diabetes UK – the nation being England, covering the period 2011-2012. The report examined the Diabetes UK health care essentials, 15 basic health checks and services that everyone with diabetes (Type 1 or Type 2) should receive from their healthcare team. These include the 9 care processes recommended by NICE but also cover specialist care availability, emotional support and in patient care.
CarbC helped to improve glycaemic control in children with type 1 diabetes using multiple daily injections. ABC use led to greater improvements in HbA1c, HBGI and LBGI compared with patients using only carbC, regardless of experience with carbC (Diabetes Research and Clinical Practice)
AstraZeneca and Bristol-Myers Squibb today announced that Xigduo™ (dapagliflozin and metformin hydrochloride in 5mg/850mg and 5mg/1000mg tablets) has been granted Marketing Authorisation by the European Commission for the treatment of type 2 diabetes in the European Union (AstraZeneca)
The prevalence of chronic conditions such as type 2 diabetes, coronary heart disease and stroke is up to 6 times higher (and they occur from a younger age) among black, Asian and other minority ethnic groups. In addition, these groups progress from being at-risk to being diagnosed with these conditions at twice the rate of white populations. (NICE)
Subjects of South Asian ethnicity with type 2 diabetes, despite being younger and leaner, had higher basal endogenous glucose production, indicating higher hepatic insulin resistance, and a trend towards higher use of carbohydrates as fasting energy substrate compared to Nordic subjects. These findings may contribute to the understanding of the observed differences in prevalence of type 2 diabetes between the ethnic groups. (PLoS ONE)
Withdrawal of rosiglitazone was associated with worsening glucose control and subsequent intensification of treatment regimen (Diabetes and Its Complications)
Rodbard HW, Visco VE et al. The Lancet. Doi: 10.1016/S2213-8587(13)70090-1
The progressive failure of oral hypoglycaemic agents and the subsequent need for insulin in Type 2 diabetes due to loss of Beta cell function is well understood. Given that the goal in most of these patients is to treat fasting hyperglycaemia, many start with a basal insulin with prandial doses added when necessary. The FullSTEP study compared this sequential use of prandial insulin with immediate use of a basal bolus regimen using Levemir and Novorapid. Unsurprisingly this non-inferiority showed exactly that – HbA1c reductions being non-significantly different (~1% from a relatively low baseline of 7.9%). However, there were significantly fewer hypos in the stepwise group than in the basal-bolus group as well as a lower dropout rate amongst the patients. There was also greater satisfaction in the stepwise group. Given the increasing numbers of Type 2 diabetes patients in the community requiring insulin, this study shows that the well established stepwise use of prandial insulin remains an ideal way of gradually intensifying insulin both from an efficacy and safety point of view.
In patients with T2DM and no history of coronary artery disease, vit-D deficiency is independently associated with impaired global longitudinal strain. This suggests that vit-D deficiency may contribute to the development of myocardial dysfunction in these patients (Journal of Diabetes and Its Complications)