Circulating Apelin is increased in T1D & T2D and associated with better glycemic control

Our study showed that apelin concentrations were increased in diabetic patients. This rise, which was greater in type 1 than in type 2 diabetic patients, suggests that obesity is not the main determinant of plasma apelin levels. The negative correlation with glycosylated hemoglobin in patients with type 2 diabetes could indicate that apelin plays a role in glycemic balance and even insulin sensitivity (Clinical Endocrinology)