The surgical panacea for diabetes: time for diabetologists to discriminate facts from fiction and flights of fantasy
Bariatric surgery is an important treatment for obesity and most patients enjoy substantial improvements in coexisting type 2 diabetes (T2D). As a result of the historic failure to establish relevant long-term controlled trials, however, there is a need to separate evidence from unfounded belief (Practical Diabetes International)
IDF releases position paper on bariatric surgery
The Paper calls for bariatric surgery to be considered earlier in the treatment of eligible patients, to help stem the serious complications that can result from diabetes (IDF)
Diabetic foot problems
Inpatient management of diabetic foot problems (NICE)
Comparative cardiovascular effects of thiazolidinediones: systematic review and meta-analysis of observational studies
Among patients with type 2 diabetes, use of rosiglitazone is associated with significantly higher odds of congestive heart failure, myocardial infarction, and death relative to pioglitazone in real world settings (BMJ)
Comparative Effectiveness and Safety of Medications for Type 2 Diabetes
Evidence supports metformin as a first-line agent to treat type 2 diabetes. Most 2-drug combinations similarly reduce hemoglobin A1c levels, but some increased risk for hypoglycemia and other adverse events (Annals of Internal Medicine)
Development and validation of The Personal Diabetes Questionnaire (PDQ)
The PDQ is a useful measure of diabetes self-care behaviors and related perceptions and barriers that is reliable and valid and feasible to administer in a clinic setting (Diabetes Research and Clinical Practice)
Diabetes and Pancreatic Cancer: Chicken or Egg?
Type 2 and type 1 diabetes mellitus increase the risk of pancreatic cancer with a latency period of more than 5 years. Type 3 diabetes mellitus is an effect, and therefore a harbinger, of pancreatic cancer in at least 30% of patients (Pancreas)
Trace elements status in diabetes mellitus type 2
The results obtained suggest that antagonistic interaction between molybdenum and copper might be involved in the progress of diabetes complications (Diabetes Research and Clinical Practice)
Increased GABAergic Output in the Ventromedial Hypothalamus Contributes to Impaired Hypoglycemic Counterregulation in Diabetic Rats
These data suggest that increased VMH GABAergic inhibition is an important contributor to the absent glucagon response to hypoglycemia and the development of counterregulatory failure in type 1 diabetes (Diabetes)
Sanofi-aventis Enters Into Research Collaboration With Columbia University to Develop New Diabetes Treatments
This three-year research collaboration, with the laboratory of Dr. Gerard Karsenty, will investigate the role of the osteoblast-secreted peptide, osteocalcin, in diabetes management (PharmaLive)
Metabolic Solutions Development Company Launches Phase 2a Trial of Its Second Compound to Treat Type 2 Diabetes
MSDC-0602 is a selective modulator of mitochondrial metabolism that modifies nutrient-sensing pathways leading to improved insulin action without direct activation of nuclear transcription factors (Therapeutics Daily)
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