Control of Pancreatic ß Cell Regeneration by Glucose Metabolism
Intracellularly, genetic and pharmacologic manipulations reveal that glucose induces ß cell replication via metabolism by glucokinase, the first step of glycolysis, followed by closure of KATP channels and membrane depolarization. Our data provide a molecular mechanism for homeostatic control of ß cell mass by metabolic demand (Cell Metabolism)
Diabetes screening among South Asians must improve
Professor Anthony Barnett of the University of Birmingham called for the UK’s South Asian population to be screened earlier for diabetes, and backed more aggressive treatment targets (GP)
Excess mortality in middle-aged men with diabetes aged 15–34 years at diagnosis
Adult men with diabetes had an almost threefold increased risk to die within 15 years of diagnosis compared to healthy men (Acta Diabetologica)
Protection From Retinopathy and Other Complications in Patients With Type 1 Diabetes of Extreme Duration
Specific AGE combinations were strongly associated with complications, indicating a link between AGE formation or processing with development of diabetic vasculopathy (Diabetes Care)
Identifying postpartum intervention approaches to prevent type 2 diabetes in women with a history of gestational diabetes
Our findings suggest that an internet-based lifestyle intervention program should be tested as a novel approach to prevent type 2 diabetes in postpartum women with a history of GDM (BMC)
Chronic Phase Shifts of the Photoperiod throughout Pregnancy Programs Glucose Intolerance and Insulin Resistance in the Rat
To gain an understanding of the potential impact of shift work during pregnancy on the long term health of the offspring, pregnant rats were subjected to chronic phase shifting of the photoperiod throughout gestation. We have shown for the first time that offspring born following this procedure had increased adiposity, increased plasma insulin, impaired glucose tolerance and glucose stimulated insulin secretion and increased whole body insulin resistance (PLoS ONE)
A Paradigm Shift in Diabetes Therapy — Dapagliflozin and Other SGLT2 Inhibitors
This review outlines the role of SGLT2 in glucose homeostasis and the evidence currently available on the potential for clinical application of these agents in diabetes (Discovery Medicine)
Vildagliptin is effective and well tolerated in Type 2 diabetics
Following pooled analyses of the safety and efficacy of Vildagliptin? in patients 75 years and over, a cautionary statement on its use in elderly patients with Type 2 diabetes has now been removed from the Summary of Product Characteristics (SmPC) of Vildagliptin, and Vildagliptin / Metformin (Hospital Pharmacy Europe)
Novo Nordisk Targets New Gut Hormone to Treat Obesity
Novo Nordisk filed a patent application for analogues of the hormone PYY which helps signal the brain when to stop eating (Bloomberg)
Dara BioSciences begins diabetes drug study
DB959 regulates certain nuclear receptors PPARs that regulate the genes involved in controlling blood sugar levels and certain lipids (PBR)
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