National Diabetes Inpatient Specialist Nurse (DISN) Group meeting
Next meeting is 2nd October 2008, Hotel Russell, London. Agenda (NDST, UK)
Investors running scared from Amylin over Byetta fears
Amylin’s bid to reassure the public about the safety of its type II diabetes drug Byetta seems to have fallen on deaf ears as the firm’s stock continues to slide (Pharma Times)
Behind the headlines – Cell reprogramming for diabetes
These results in mice – albeit in a small sample of them – are promising but in terms of any application to human disease they must be interpreted in the right context: preliminary results suggesting a potential application of a new and exciting technology (NHS Choices, UK)
Obesity epidemic spreads to new areas in the south
A new “fat map” of the UK shows that obesity may be worsening in spite of efforts to fight it and parts of southern England are succumbing for the first time (Guardian, UK)
Low-glycemic index meals produce significantly lower PPGE
Lower PPGE was observed with low-glycemic index meals when compared to high-glycemic index meals … findings indicate that the optimal therapy for a low-glycemic index meal in children with type 1 diabetes is preprandial ultra-short-acting insulin (American Diabetes Association)
Impact of Disease Management on Utilization and Adherence With Drugs and Tests
The FAHS telephonic care management intervention effectively induced Medicaid patients with diabetes to begin treatment and improved adherence to oral hypoglycemic agents and recommended tests (American Diabetes Association)
Multisystemic Therapy for Adolescents With Poorly Controlled Type 1 Diabetes
The study demonstrates the value of intensive behavioral interventions for high-risk youth with diabetes for reducing one of the most serious consequences of medication noncompliance (Diabetes Care)
Obesity and Undiagnosed Diabetes in the U.S.
Despite a higher underlying risk of diabetes and widespread clinical recognition of this higher risk, obesity does not increase the likelihood that an individual’s diabetes will be diagnosed (Diabetes Care)
Where’s The Activity in Diabetes Self-Management?
What leaves me less than inspired is the continued lack of attention given to physical activity in determination of insulin doses (Diabetes Mine)
New treatment for type two diabetes
The drug, Januvia, is now listed on the Pharmaceutical Benefits Scheme (Sydney Morning Herald, Australia)
Diabetes Australia disappointed by junk food advertising decision
Diabetes Australia has warned Australia has taken a step backwards in the fight against childhood obesity following a recommendation not to restrict junk food advertising to children (Diabetes Australia)
6 eHealth contribution to NHS Scotland’s strategic aims
To date eHealth’s focus has been in the area of the common cancers and diabetes (Scottish Government, UK)
Four more Byetta deaths but Amylin and Lilly defend drug
Shares in Amylin Pharmaceuticals have taken a bashing in after-hours trading after the firm and partner Eli Lilly reported four new deaths among patients with pancreatitis who took their type II diabetes drug Byetta, in addition to the two cases reported last week by US regulators (PharmaTimes)
Sector Snap: Diabetes drug treatments
The multibillion-dollar diabetes drug market is teeming with competitors both current and anticipated, including Byetta and its most immediate threat to sales, Novo Nordisk’s not-yet-approved liraglutide (CNBC)
Diabetes Osteomyelitis Management & Outcome Study
This web-based project will start on the 1st May 2008, and it will be possible to register patients on line for just 6 months (ABCD)
A Study Assessing an Injection Port for Administration of Insulin
This study supports the utility and efficacy of administering multiple doses of insulin through a single I-PORT device and concludes that the I-PORT is a viable alternative to SI (Diabetes Spectrum)
Cardiovascular Disease and Diabetes
Comprehensive guidelines, improved diagnosis, and effective treatments have definitely helped decrease mortality from CVD during the past few decades, but there is still more clinicians can do to help (Diabetes Spectrum)
The Pathophysiology of Cardiovascular Disease and Diabetes: Beyond Blood Pressure and Lipids
This article reviews the biological basis of the link between diabetes and CVD, from defects in the vasculature to the cellular and molecular mechanisms specific to insulin-resistant states and hyperglycemia (Diabetes Spectrum)
Tories warn of obesity ‘excuses’
The Tories say people should take more responsibility for their lifestyles, exercise more and eat more healthily (BBC, UK)
Obesity in older adults: a systematic review of the evidence for diagnosis and treatment
The authors stated that intensive interventions (including diet, physical activity and behavioural components) can promote modest weight loss, but the data are insufficient to evaluate surgical or pharmacological treatments (CRD, UK)
Cells change identity in promising breakthrough
The cell identity switch turned ordinary pancreas cells into the rarer type that churns out insulin, essential for preventing diabetes (American Diabetes Association)
The Unraveling of Incretin Biology
New Dimensions in the Management of Type 2 Diabetes (Medscape)
Colesevelam hydrochloride improved glycemic control
Patients with type 2 diabetes receiving sulfonylurea-based therapy improved glycemic control and reduced LDL cholesterol after the addition of colesevelam hydrochloride treatment, according to the findings from a recent study (Endocrine Today)
Guiding the way: dealing with diabetes and mental health problems
Diabetes Australia and SANE Australia today launched an Australian-first, a guide to help the nearly 1 million Australians diagnosed with diabetes maintain good mental health (Diabetes Australia )
Anaemia and kidney dysfunction in Caribbean Type 2 diabetic patients
A high prevalence of anaemia was identified in this group of type 2 diabetic patients previously shown to have a high prevalence of the metabolic syndrome (Cardio Vascular Diabetology)
Caesarean babies’ ‘diabetes risk’
Children born by Caesarean section have a 20% higher risk of developing type 1 diabetes than those born naturally, says a report in PubMed journal (BBC, UK)
T1 Kids
A new website for children with type 1 diabetes launched (JDRF)
Beyond the Era of NPH Insulin—Long-Acting Insulin Analogs: Chemistry, Comparative Pharmacology, and Clinical Application
This review describes blood glucose homeostasis by insulin in people without diabetes and outlines the physiological application of exogenous insulin in patients with type 1 and type 2 diabetes (Diabetes Technology & Therapeutics)
Diabetes Linked to Cognitive Problems
Researchers reporting in the August issue of Archives of Neurology have linked mild cognitive impairment to earlier onset, longer duration, and greater severity of diabetes (WebMD)
Physical activity and overweight in children and adolescents using intensified insulin treatment
To increase physical activity to recommended level and limit TV viewing should be an important issue in education of all children and adolescents with type 1 diabetes, independent of insulin regimen (Pediatric Diabetes)
Diabetes T-cell treatment advance
A way to isolate and kill defective immune system T-cells that cause insulin-dependent diabetes is being researched by scientists using tumour necrosis factor (Pharmacy Europe)
Endocrinologists and Surgeons Join Forces to Fight Type 2 Diabetes
At the 1st World Congress for Interventional Therapies for Type 2 Diabetes, prominent endocrinologists from around the world will convene in an exchange with leading surgeons about the role of surgery and other emerging new therapies for type 2 diabetes (Newswise)
Learn about managing diabetes
Taking part in one of our Living with diabetes days will help people to achieve better control of their diabetes through self management (Diabetes UK)
The Accuracy and Efficacy of Real-Time Continuous Glucose Monitoring Sensor in Patients with Type 1 Diabetes
RT-CGM is safe and well tolerated and provides readings that are in close agreement with glucose meter values (Diabetes Technology & Therapeutics)
Improved Glycemic Control in Intensively Treated Adult Subjects with Type 1 Diabetes Using Insulin Guidance Software
This is the first report that shows improved glycemic control can be maintained over 12 months in patients with type 1 diabetes by using Advisor with no change in insulin dose and weight (Diabetes Technology & Therapeutics)
Sensor-Augmented Insulin Pump Therapy
Results of the First Randomized Treat-to-Target Study (Diabetes Technology & Therapeutics)
No association found between low-fat diet and a reduction in diabetes risk
The authors concluded that a low-fat diet had no effects on the risk of diabetes, but a reduction in weight may be beneficial in decreasing such a risk (American Diabetes Association)
Beta cell glucose sensitivity is decreased by 39% in non-diabetic individuals carrying multiple diabetes-risk alleles
This study shows how individual type 2 diabetes-risk alleles combine in an additive manner to impact upon pancreatic beta cell function in non-diabetic individuals (PubMed)
Generex Biotechnology Corporation Signs Oral Insulin Distribution Deal for Korea
Generex Biotechnology Corporation the leader in drug delivery for metabolic diseases through the inner lining of the mouth, has entered into a product licensing and distribution agreement with Dong-Sung Pharm Co. Ltd. (BioSpace)
XTend Medical (XMDC) Signs Exclusive Global Distribution Agreement With DDI
Although the Vibration Device for Pre-Screening of Diabetic Neuropathy can pre-screen people that may have diabetic neuropathy, the first signs that diabetes may be present, it also assists the current diabetic patient with monitoring their neuropathy levels so their disease is managed correctly (Yahoo)
Comparison of gliclazide with insulin as initial treatment modality in newly diagnosed type 2 diabetes
Comparable glycemic control could be achieved with both insulin and oral hypoglycemic agent in newly diagnosed type 2 diabetes subjects. Insulin treatment exceeded gliclazide in the remission (drug-free) rate (PubMed)
Absence of an acute insulin response predicts onset of type 2 diabetes
In these Caucasian persons with IGT, the absence of the first insulin peak was the strongest predictor of T2DM (PubMed)
From the bench to the bedside: dipeptidyl peptidase IV inhibitors, a new class of oral antihyperglycemic agents
This article provides an overview of the recent advances in and the lessons learned from the design of potent and selective small-molecule inhibitors of DPP-IV for the treatment of type 2 diabetes (PubMed)
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