Insulin Resistance Status
Among overweight children in primary care practices, a significant relationship was found between insulin resistance and the change in BMI z score associated with a dietitian-mediated intervention (Archives of Pediatric and Adolescent Medicine)
Consultant pressure is compromising diabetes care
According to a recent study in the latest edition of Clinical Medicine, pressure on consultants to support internal medicine services could be compromising diabetes care in the UK (Diabetes.co.uk)
Containing the global diabetes tsunami worldwide
Before any epidemic can be managed, new knowledge about clinical and educational issues must be obtained and applied to the problem. An article by R. Paul Robertson, M.D., president elect of the American Diabetes Association and Pierre Lefebvre, M.D., Ph.D., immediate past president of the International Diabetes Federation (Seattle PI, USA)
Towards an Artificial Pancreas Public Meeting (Day 1)
Video (NIH, USA)
Towards an Artificial Pancreas Public Meeting (Day 2)
Video (NIH, USA)
Intensive Glycemic Control Lowers Plasma Visfatin Levels in Patients with Type 2 Diabetes
We conclude that the change of visfatin concentration may be a compensatory mechanism to ameliorate insulin deficiency due to pancreatic ß-cell dysfunction (Thieme-connect)
Broccoli and diabetes
An evaluation of the BBC article (NHS Choices)
American Diabetes Association Collaborates With Healia
Premier Diabetes Organization Provides Expert Support to Online Diabetes Health Communities (MarketWatch, USA)
Low-Fat Diet May Not Protect Postmenopausal Women From Diabetes Risk
A low-fat diet in basically healthy postmenopausal women demonstrates no evidence of decreasing the risk for diabetes after 8.1 years, according to the results of a randomized controlled trial (Diabetes In Control , USA)
Nutritious food and more exercise not enough to stop diabetes epidemic
President of Diabetes Australia Gary Deed says that while eating more nutritious food and exercising regularly will aid the prevention of type 2 diabetes, it won’t be enough to slow the growth of Australia’s diabetes epidemic (Diabetes Australia)
Associations of Adiponectin, Resistin, and Tumor Necrosis Factor- with Insulin Resistance
Adverse levels of adipokines are associated with insulin resistance in individuals at low or high diabetes risk (Journal of Clinical Endocrinology & Metabolism)
Replication of Genome-Wide Association Studies of Type 2 Diabetes Susceptibility in Japan
Some of these variants represent common type 2 diabetes-susceptibility genes in both Japanese and Europeans (Journal of Clinical Endocrinology & Metabolism)
Dietary Glycemic Index, Development of Islet Autoimmunity, and Subsequent Progression to Type 1 Diabetes in Young Children
Higher dietary glycemic index and glycemic load are not associated with IA development, but higher glycemic index is associated with more rapid progression to type 1 diabetes in children with IA, perhaps due to increased demand on the Beta-cell to release insulin (Journal of Clinical Endocrinology & Metabolism)
Youth and parent education about diabetes complications: health professional survey
Patient characteristics and professionals’ attitudes were associated with experts’ willingness to inform families about long-term diabetic complications. Further research should explore how these practice variations affect coping with diabetes (Pediatric Diabetes)
Too much iron can cause diabetes
According to reports from America, common disease hemochromatosis is a major risk for developing diabetes, not to mention other diseases including congestive heart failure (Daibetes.org.uk)
Broccoli could reverse the heart damaging effects of diabetes
Professor Paul Thornalley and his team from the University of Warwick have found a broccoli compound called Sulforaphane. This compound can encourage the body to produce more enzymes to protect the vessels, as well as reduce high levels of molecules which cause significant cell damage (University of Warwick, UK)
Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease
We conclude that activation of nrf2 may prevent biochemical dysfunction and related functional responses of endothelial cells induced by hyperglycemia in which increased expression of transketolase has a pivotal role (Diabetes)
94 percent of doctors surveyed are aware of relationship between type 2 diabetes and sleep apnea
Yet only 47 percent conduct routine screening; sleep apnea screening protocol designed to close the gap between theory and practice (EurekAleet, USA)
Lilly Diabetes Drug Shows a Life-Extending Promise
Neither Eli Lilly or Amylin, the companies that jointly market Byetta, is publicizing the findings, in part because no one is sure whether the reduction in the death rate is real or a chance finding (New York Times, USA)
Diabetes trial nets BTG $7.5m milestone payment (ShareCast)
BTG is up again after the start of a pivotal phase III clinical trial of otelixizumab (TRX4) in patients with new onset type 1 diabetes triggered a milestone payment of $7.5m to the life sciences firm (ShareCast)
Snack firms pledge a further £200m to the Government’s £75m budget to fight obesity
More than £200m has been pledged by several food and drinks companies in a bid to tackle obesity (Binleys, UK)
Lowering BMI in patients with type 2 diabetes: try regular breakfast, weigh-ins, no fast food
Researchers with the Look AHEAD Research Group evaluated weight loss strategies related to BMI in 5,145 overweight patients with diabetes (Endocrine Today)
Differences in Family Mealtime Interactions between Young Children with Type 1 Diabetes and Controls: Implications for Behavioral Intervention
When differences in family mealtime behaviors have been found in other pediatric groups (e.g., cystic fibrosis), the results have directly informed the development of effective interventions. The clinically relevant results of this study can be used to inform interventions for young children with TIDM (Pediatric Psychology, USA)
Society’s big fat lie depresses diabetics
A survey of 2,300 type 1 diabetics and their relatives found that more than half of all parents were frequently blamed for their child’s condition (Sydney Morning Herald, Australia)
Diabetes breakthrough recognised in Eureka Prizes nominations
Dr Carola Vinuesa, an immunologist from ANU, has been nominated as a finalist for her discovery of Roquin, a gene that causes type 1 diabetes and lupus (Daibetes Australia)
AACE Patient Safety Editorials – Insulin Pens and Safety
The Institute for Safe Medication Practices (ISMP) released an article recently that highlighted potential safety problems that are being seen in hospitals when they switch the delivery of insulin subcutaneously from insulin that is drawn from multiple-dose vials to insulin pens (American Association of Clinical Endocrinologists)
Diabetes type 3: A brief review
The combination of diabetes type 2 and Alzheimer’s disease is recently mentioned as a new classification of diabetes, diabetes type 3 (Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Cell-based treatments for diabetes
For almost a century the only available treatment for T1DM has been the administration of exogenous insulin to suppress hyperglycaemia. It is now a real possibility that the next decade will see the widespread application of cell-based therapies to cure this disorder (Drug Discovery Today)
Excessive and Binge Drinking May Increase Risk for Metabolic Syndrome
Increased drinking exceeding the US Dietary Guidelines and binge drinking once or more per week in men and women is associated with an increased risk for metabolic syndrome (Medscape)
Parents will be told if their children are overweight
From September this year, parents of children who have been weighed and measured at school could automatically receive their child’s results in a bid to get parents to be more aware about healthy lifestyles, and help their children achieve a healthy weight (DoH, UK)
Persistence of Pre-Diabetes in Overweight and Obese Hispanic Children
Association With Progressive Insulin Resistance, Poor Beta-cell Function and Increasing Visceral Fat (Diabetes, USA)
American diabetics fight for continuous glucose monitoring system
A group of people with diabetes in America has launched a new campaign to help persuade insurance companies to allow claims for continuous glucose monitoring systems (Diabetes UK)
Do You Know What You Are Eating?
American Diabetes Association launches an online nutrition tool – MyFoodAdvisor(TM) – that unlocks the mystery of what is in many of the foods you eat (American Diabetes Association)
For Women with Diabetes: Your Guide to Pregnancy
You have type 1 or type 2 diabetes and you are pregnant or hoping to get pregnant soon. You can learn what to do to have a healthy baby. You can also learn how to take care of yourself and your diabetes before, during, and after your pregnancy (NDIC, USA)
GI News
This month, as GI News heads into its fourth year with 50,000 plus subscribers, Prof Jennie Brand Miller sets out the key to eating a low GI diet and Susie Burrell begins a new series for Healthy Kids sharing some practical lessons she has learned as a specialist paediatric dietitian (GI News, Australia)
Hyperglycemia-induced reactive oxygen species toxicity to endothelial cells is dependent on paracrine mediators
Our in vitro results indicate that HRECs respond to cytokines rather than high glucose, suggesting that in vivo diabetes-related endothelial injury in the retina may be due to glucose-induced cytokine release by other retinal cells and not a direct effect of high glucose (PubMed, USA)
A matter of insulin: developmental programming of body weight regulation
Epidemiological, clinical, as well as experimental data obtained by our group during the past two decades indicate that insulin itself, when occurring in elevated concentrations during perinatal life, may program the development of obesity and diabetes (PubMed, USA)
Fetal programming of glucose-insulin metabolism.
Programmed changes in beta cell function and insulin action have been a common feature of animal models of poor intrauterine nutrition. Fundamental underlying mechanisms are starting to emerge, including changes in the epigenotype and mitochondrial function (PubMed, USA)
Resistin and insulin resistance in hepatocytes: Resistin disturbs glycogen metabolism at the protein level
These results strongly suggest that resistin effects glycogen metabolism at the protein level, and resistin is highly associated with insulin resistance and type 2 diabetes and is a candidate for the prevention and treatment of type 2 diabetes (PubMed, USA)
Blood Glucose Awareness Training Delivered Over the Internet
The internet may be an efficient and effective means of delivering diabetes interventions like BGAT (Diabetes Care, USA)
Emerging markets boost Astra Zeneca profits
The company said it now had 12 drugs in the final stage of development and had submitted its diabetes treatment Onglyza for regulatory approval (Telegraph, UK)
Study Predicts Obesity Apocalypse by 2030
The increase in metabolic disease and other weight-related conditions could have a catastrophic toll on public health — and on the public pocket (ABC News, USA)
Public perception of overweight
Heavier people were less likely to think that they were overweight in 2007 than in 1999 (BMJ, UK)
NHS spends £750m on drugs to treat lifestyle diseases
For the first time ever, more money is being spent on treating diabetes than any other single disease (Telegraph, UK)
Diabetes in America
Public Knowledge, Perceptions and Behaviors (By Gallup for Novo Nordisk National Changing Diabetes® Program. 131-page PDF (NCDP)
USF receives $128 million award for diabetes research
The National Institutes of Health awarded $128 million to a University of South Florida research team conducting worldwide studies on the prevention and treatment of juvenile diabetes (Business Journal, USA)
Designed for Disease
The Link Between Local Food Environments and Obesity and Diabetes. 10-page PDF (California Center for Public Health Advocacy, PolicyLink, and the UCLA Center for Health Policy Research)
Joslin Study Finds Insulin Resistance Causes Gallstones
It has been known for more than 100 years that gallstones are more common in obese individuals. Now, researchers at the Joslin Diabetes Center have determined that insulin resistance is likely the reason why (Joslin Diabetes Center, USA)
AtheroGenics Reports Positive Results From ANDES Phase 3 Clinical Trial of AGI-1067 in Type 2 Diabetes
Based on the results of this successful trial, AtheroGenics intends to rapidly move forward with development of AGI-1067 (AtheroGenics, USA)
Oral benfotiamine plus a-lipoic acid normalises complication-causing pathways in type 1 diabetes
These results show that the previously demonstrated beneficial effects of these agents on complication-causing pathways in rodent models of diabetic complications also occur in humans with type 1 diabetes (Diabetologia)
The Rising Incidence of Type 1 Diabetes Is Accounted for by Cases With Lower-Risk Human Leukocyte Antigen Genotypes
The rising incidence and decreasing age at diagnosis of type 1 diabetes is accounted for by the impact of environment on children with lower-risk HLA class II genes, who previously would not have developed type 1 diabetes in childhood (Diabetes Care, USA)
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