Insulin Training Hits 20,000 Mark
The course is mandatory for all medical students and is in the process of being rolled out to all junior doctors. We have customised it for nurses by adding videos of injecting techniques. It will be available to all nurses in the New Year (NHS Diabetes)
Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients
Here, we report the development of a noninvasive method to visualize T1D at the target organ level in patients with active insulitis. Specifically, we visualized islet inflammation, manifest by microvascular changes and monocyte/macrophage recruitment and activation, using magnetic resonance imaging of magnetic nanoparticles (Journal of Clinical Investigation)
BACE2 plays a role in the insulin receptor trafficking in pancreatic ß-cells
All these data point to a role for BACE2 in the IRß trafficking and insulin signaling. In conclusion, BACE2 is hereby presented as an important enzyme in ß-cell function (Endocrinology and Metabolism – Abstract)
Cardiovascular risk factors in children exposed to maternal diabetes in utero
Compared with unexposed children, healthy offspring exposed to maternal diabetes in utero have a worse cardiovascular risk profile. In particular, offspring have substantially increased levels of circulating cellular adhesion molecules, which are biomarkers of adverse endothelium perturbation and may be related to the earliest preclinical stages of atherosclerosis and diabetes (Diabetologia)
The role of metabolic and hemodynamic factors for podocyte injury in diabetes
In this review we discuss the common pathways leading to podocyte death as well as novel pathways and concepts of podocyte dedifferentiation and detachment that influence the progression of diabetic glomerulopathy (Diabetes Metabolism Research and Reviews)
The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity
The inflammasome is an important regulator of adipocyte function and insulin sensitivity, and caspase-1 inhibition may represent a novel therapeutic target in clinical conditions associated with obesity and insulin resistance (Cell Metabolism)
A Serum Factor Induces Insulin-Independent Translocation of GLUT4 to the Cell Surface which Is Maintained in Insulin Resistance
Taken together, we have demonstrated the presence of a factor (or several factors) in serum that induce GLUT4 translocation in a manner that is largely independent of insulin and insulin signaling and whose effects are fully maintained in insulin resistance (PLoS ONE)
What to add in with metformin in type 2 diabetes?
This review considers the therapeutic choices currently faced by people with type 2 diabetes and those caring for them when glucose levels initially controlled with lifestyle management and metformin start to rise (QJM)
DREAM passive follow-up study reports persistent effect of rosiglitazone
The DREAM On results suggest that rosiglitazone effects may persist after active treatment cessation and delay diabetes progression but cannot reverse the primary disease (American Diabetes Association)
Novo and Emisphere pair up again under insulin pill deal
Danish drugmaker Novo Nordisk and US group Emisphere Technologies have formed a pact to develop and commercialise oral insulins for the management of diabetes, marking the second alliance between the two firms (PharmaTimes)
Sanofi-aventis Acquires from Ascendis Pharma Worldwide Rights on Drug-Delivery Technology in Diabetes and Related Disorders
The technology creates transient bonds between larger molecules such as proteins and peptides, including insulin, and a carrier. This allows for tailor-made release profiles, with no initial burst and high drug load formulations. The TransCon Linker technology has shown promising results in preclinical studies in delivering insulin (Sanofi-aventis)
Leptin Activates a Novel CNS Mechanism for Insulin-Independent Normalization of Severe Diabetic Hyperglycemia
Leptin action in the brain potently suppresses hepatic glucose production while increasing tissue glucose uptake despite persistent, severe insulin deficiency. This leptin action is distinct from its previously reported effect to increase insulin sensitivity in the liver and offers compelling evidence that the brain has the capacity to normalize diabetic hyperglycemia in the presence of sufficient amounts of central nervous system leptin (Endocrinology – Abstract)
Generalized impairment of vasodilator reactivity during hyperinsulinemia in patients with obesity-related metabolic syndrome
Insulin exerts a generalized facilitatory action on vasodilator reactivity, and this effect is impaired in patients with MetS likely because of increased oxidative stress (Endocrinology and Metabolism)
Treatment of dyslipidemia in patients with type 2 diabetes
This review outlines the characteristics and prevalence of dyslipidemia in patients with type 2 diabetes and discusses strategies that may reduce the risk of cardiovascular disease in this population (Lipids in Health and Disease)
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