Age-related islet autoantibody incidence in offspring of patients with type 1 diabetes
The age period 9 months to 2 years is associated with a high incidence of activation of type 1 diabetes-associated autoimmunity in genetically at-risk children and should be targeted for effective primary prevention strategies (Diabetologia)
Continuous Subcutaneous Insulin Infusion of Insulin Lispro in Children and Adolescents with Type 1 Diabetes
In 26 studies of over 2500 pediatric and adolescent patients with type 1 diabetes, with over 1000 patients specifically receiving lispro CSII, insulin lispro CSII therapy consistently demonstrated similar or improved efficacy and safety versus studied comparators (Endocrine Practice)
Profile of Inflammatory Mediators in Gestational Diabetes Mellitus: Phenotype and Genotype
Women with GDM have significantly lower adiponectin levels in the third trimester, regardless of BMI (American Journal of Reproductive Immunology)
Peri-conception hyperglycaemia and nephropathy are associated with risk of congenital anomaly in women with pre-existing diabetes
A population-based cohort study (Diabetologia)
Mitochondrial Fission Triggered by Hyperglycemia Is Mediated by ROCK1 Activation in Podocytes and Endothelial Cells
Several lines of evidence suggest that mitochondrial dysfunction plays a critical role in the pathogenesis of microvascular complications of diabetes, including diabetic nephropathy … These findings provide insights into the unexpected role of ROCK1 in a signaling cascade that regulates mitochondrial dynamics (Cell Metabolism)
Helicobacter pylori Infection Is Associated With an Increased Rate of Diabetes
We demonstrated for the first time that H. pylori infection leads to an increased rate of incident diabetes in a prospective cohort study. Our findings implicate a potential role for antibiotic and gastrointestinal treatment in preventing diabetes (Diabetes Care)
Diabetes Working Group White Paper
Through new research sponsored by the DWG, this white paper examines provider barriers to offering the current standards of diabetes care and offers recommendations to mitigate these barriers (Avalere Health LLC on behalf of the Diabetes Working Group)
Long-term conditions and mental health – The cost of co-morbidities
More than 4 million people in England with a long-term physical health condition also have mental health problems, and many of them experience significantly poorer health outcomes and reduced quality of life as a result – Download (The King’s Fund, UK)
The pathogenesis of early retinal changes of diabetic retinopathy
This review explores the earliest changes to the retina in DR and the factors that predispose or prevent DR, including sleep apnoea, receptor degenerations laser treatment and VEGF polymorphism. The review also presents the evidence that retinal hypoxia, existing in the earliest stages, causes DR (Documenta Ophthalmologica)
Oral Pharmacologic Treatment of Type 2 Diabetes Mellitus
A Clinical Practice Guideline From the American College of Physicians (Annals of Internal Medicine)
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