Diabetes News February 25th 2011

Type 1 diabetes in children
Easily Missed? (BMJ)

Diabetes management: optimizing roles for nurses in insulin initiation
This manuscript reviews the benefits of intensive glycemic control in type 2 diabetes, therapeutic goals and guidelines, advances in insulin therapy, and contribution of nurses in overcoming barriers to insulin initiation and related aspects of diabetes care (Journal of Multidisciplinary Healthcare)

Hemoglobin A1c and Mean Glucose in Patients With Type 1 Diabetes
Analysis of data from the Juvenile Diabetes Research Foundation continuous glucose monitoring randomized trial (Diabetes Care)

Nontraditional Markers of Glycemia Associations with microvascular conditions
In cross-sectional analyses, two serum markers of glycemia—glycated albumin and fructosamine—are as, or more strongly, associated with microvascular conditions as HbA1c (Diabetes Care)

Better Weight Loss, Resolution of Diabetes, and Quality of Life for Laparoscopic Gastric Bypass vs Banding
When performed in high-volume centers by expert surgeons, Roux-en-Y gastric bypass (RYGB) has a similar rate of overall complications and lower rate of reoperations than laparoscopic gastric banding (LB). With the benefit of greater weight loss, increased resolution of diabetes, and improved quality of life (Archives of Surgery)

Increasing duration of type 1 diabetes perturbs the strength–structure relationship and increases brittleness of bone
In a mouse model, diabetes diminishes cortical structure and trabecular architecture. ? As duration increases diabetes alters the relationship between strength and structure (Bone)

Serum advanced glycation end products is associated with insulin resistance
We have demonstrated that circulating level of AGEs is associated with insulin resistance even in non-obese, non-diabetic subjects independent of adiponectin (Diabetes/Metabolism Research and Reviews)

Glucose-Dependent Changes in SNARE Protein Levels in Pancreatic ß-Cells
The results suggest that high glucose has a direct toxic effect on the secretory pathway by decreasing the expression of insulin granule SNARE-associated proteins (Endocrinology)

Cardamonin Stimulates Glucose Uptake through Translocation of Glucose Transporter-4 in L6 Myotubes
Results suggest that cardamonin is a promising active compound for maintaining glucose homeostasis, and that it acts via an unknown mechanism that does not involve activation of the downstream insulin signal and AMP-activated protein kinase (Phytotherapy Research)

Insulin jet injectors improve the pharmacokinetic and pharmacodynamic profile of rapid-acting insulin
New research has shown that the pharmacokinetic and pharmacodynamic profile of rapid-acting insulin is improved by using jet injectors, which use a high-velocity jet to deliver insulin into the subcutaneous region instead of a needle (DiabetePro)

ONGLYZA™ (saxagliptin) U.S. Label Update
U.S. Label Update Provides Further Evidence Regarding Use in Renally Impaired Adults with Type 2 Diabetes (Bristol-Myers Squibb)

Surgical management of diabetic foot infections – lecture
Dr Wukich reviews the epidemiology, recognition, and treatment of diabetic foot infections. He also introduces the results of upcoming published research on postoperative infections in diabetics (present PODIATRY)