Diabetes News January 29th 2010

Scottish Public Health Observatory – Diabetes update

Diabetes Mortality Data – – Diabetes Secondary Care Data (ScotPHO)

The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes: retrospective epidemiological analysis of the ACCORD study
Symptomatic, severe hypoglycaemia does not appear to account for the difference in mortality between the two study arms up to the time when the ACCORD intensive glycaemia arm was discontinued (BMJ)

Diabetes sugar ‘can go too low’
Cardiff researchers looked at nearly 50,000 patients with type 2 diabetes and found the lowest glucose levels linked to a heightened risk of death (BBC, UK)

Novo Nordisk gets US approval for Victoza but with warning
At long last, Novo Nordisk has been given regulatory approval across the Atlantic for its diabetes drug Victoza (PharmaTimes)

New drug for diabetics could end ordeal of daily insulin jabs
It is an oral form of Victoza, a medicine already approved for use in diabetes … Novo Nordisk, the company that makes the drug, has turned it into a pill and is recruiting 155 patients in Britain to try it out in a trial, which is expected to last a year (Daily Mail, UK)

Alizé Pharma Signs Research Collaboration and License Option Agreement With Lilly
Companies to collaborate on an exclusive basis on Alizé Pharma’s unacylated ghrelin (AZP-01) program for the treatment of Type II diabetes (PharmaLive)

Phase 2 Trial of LX4211 Demonstrates Significant and Rapid Improvements in Multiple Parameters in Type 2 Diabetic Patients
Significant Improvements in Glycemic Control – Significant Reduction in HbA1c within Four Weeks – Favorable Safety, Cardiovascular and Metabolic Profile Observed (PharmaLive)

The dual-wave bolus feature in type 1 diabetes adult users of insulin pumps
We assessed the effectiveness of DWB in 56 adult patients with type 1 diabetes (T1DM) who were on continuous subcutaneous insulin infusion via insulin pump for at least 2 years (Acta Diabetologica)

One in every five hospital patients battling diabetes
Professor Anthony Barnett, clinical director for diabetes at Heart of England NHS foundation trust, blamed unhealthy lifestyles for the sharp increase [Daily Mail, UK]

Beta cells need key protein to divide and conquer diabetes
Cyclin D2 is a member of a small family of proteins that aid in the cell cycle, by which cells divide into two. Earlier studies had demonstrated that cyclin D2 is particularly important to the replication of beta cells but had not directly addressed its role in insulin resistance (Joslin Diabetes Center)

Therapeutic Options for Diabetic Foot Infections
This article reviews the commonly used therapeutic options for treatment, including many newer antibiotics developed to target multidrug-resistant gram-positive bacteria, and includes available data relating specifically to the tissue penetration of these agents (Journal of the American Podiatric Medical Association)

Attainment of Canadian Diabetes Association recommended targets in patients with type 2 diabetes
In this paper, which reports on parts 1 and 2 of our study, we document physicians’ knowledge of the CDA recommended targets for HbA1c, BP, and LDL-C in the province of Newfoundland and Labrador, and the degree to which these targets were achieved in 8 family practices in St John’s, Nfld (Canadian Family Physician)

Diabetes and Dietary Supplements
It is important for health care practitioners not only to be aware of what dietary supplements their patients are taking, but also to understand how these supplements work and their possible side effects (Clinical Diabetes)

Microparticle levels may be an indicator of vascular dysfunction in diabetes patients
The study results showed that the levels of circulating MP, particularly EMP, may be an important indicator of vascular dysfunction (ADA)