Diabetes News January 7th 2011

Type 2 diabetes in younger adults: the emerging UK epidemic
This focused review of the epidemiology, aetiology, clinical outcomes, comorbidities and management of younger adults with T2DM will provide the non-specialist with up-to-date insight into the UK’s emerging epidemi (Post Graduate Medical Journal)

Prediction of gestational diabetes mellitus by maternal factors and biomarkers at 11 to 13 weeks
First-trimester screening for GDM can be provided by a combination of maternal characteristics and biomarkers (Prenatal Diagnosis)

HbA1c levels in schoolchildren with type 1 diabetes are seasonally variable and dependent on weather conditions
Seasonal changes of HbA1c levels in schoolchildren with type 1 diabetes are a significant phenomenon and should be considered in patient education and diabetes management (Diabetologia)

Activation of Vascular Bone Morphogenetic Protein Signaling in Diabetes Mellitus
Hyperglycemia and diabetes activate vascular BMP activity, which is instrumental in promoting vascular calcification and may be limited by increasing BMP inhibition (Circulation Research)

Diabetes and Cardiovascular Disease: The Potential Benefit of Incretin-Based Therapies
In this review, we discuss recent findings concerning the potential, yet untested, benefits of incretin-based pharmacotherapy in the treatment of cardiovascular disease (Current Atherosclerosis Reports)

Lowering the Triglyceride/High-Density Lipoprotein Cholesterol Ratio
Lowering the Triglyceride/High-Density Lipoprotein Cholesterol Ratio Is Associated With the Beneficial Impact of Pioglitazone on Progression of Coronary Atherosclerosis in Diabetic Patients (Journal American College of Cardiology)

Increased epicardial adipose tissue in type 1 diabetes is associated with central obesity and metabolic syndrome
Young non-obese type 1 diabetic women with central adiposity and/or MS may have increased EAT, what may predict CAD risk (Diabetes Research and Clinical Practice)

Diagnosis and Treatment of Diabetic Peripheral Neuropathy
Dr. Lavery reviews the various screening tests that will help the practitioner make a correct diagnosis. Audio-visual lecture (Present PODIATRY)

Scientists find link between gene and diabetes drug mechanism
EU-funded scientists say they have genetic proof of how a commonly used diabetes drug works (CORDIS)

Vitamin D deficiency is associated with type 2 diabetes mellitus in HIV infection
Our study demonstrates an association between vitamin D deficiency and type 2 diabetes mellitus. Clinical trials are needed to better characterize the association between vitamin D deficiency and type 2 diabetes mellitus in HIV infection and to evaluate whether vitamin D is able to prevent or delay the onset of type 2 diabetes mellitus (AIDS)

Use of Twice-Daily Exenatide in Basal Insulin–Treated Patients With Type 2 Diabetes
Adding twice-daily exenatide injections improved glycemic control without increased hypoglycemia or weight gain in participants with uncontrolled type 2 diabetes who were receiving insulin glargine treatment (Annals of Internal Medicine)

Amylin and Lilly Seek Expanded Use of Byetta Along with Basal Insulin
Amylin Pharmaceuticals, Inc. and Eli Lilly and Company announce that a supplemental New Drug Application has been submitted to the U.S. Food and Drug Administration for the expanded use of BYETTA(R) (exenatide) injection as an add-on therapy to basal insulin (PharmaLive)

Novo Nordisk’s innovative needle – NovoTwist® – wins GOOD DESIGN™ Award
Novo Nordisk has been awarded the 2010 GOOD DESIGN™ Award for NovoTwist®, the innovative needle designed for use with the Novo Nordisk insulin delivery device FlexPen® and Victoza® (liraglutide) Pen (Novo Nordisk)

MannKind Updates Status of New Drug Application for AFREZZA(R)
The U.S. Food & Drug Administration agency will will require approximately four additional weeks to complete its review of the New Drug Application for AFREZZA(R) (insulin human – rDNA origin) Inhalation Powder (MannKind Corporation)