Diabetes Week 2008 – a serious success
Diabetes UK would like to say a huge ‘Thank You’ to everyone who helped to make this year’s Diabetes Week such a great success [Diabetes UK]
Will the NICE guidelines on diabetes in pregnancy improve outcomes?
If followed, these guidelines should bring tangible improvements to the standards of care which hopefully will lead to improvements in pregnancy outcomes compared to those published in the CEMACH audit of 2002 to 2003 [British Journal of Diabetes Vascular Disorders]
Current screening test for prediabetes in children misses the diagnosis too often
Obese children, who are at increased risk for prediabetes and type 2 diabetes, may not be getting the most appropriate test to screen for these conditions, a new Canadian study found [EurekAlert]
Relationship between Insulin Sensitivity and IGF-I Sensitivity in Low Birth Weight Prepubertal Children
Our findings suggest that reduced sensitivity to insulin and IGF-I may coexist in some prepubertal LBW children [Hormone Research]
Glucoregulation is more precise in women than in men during postexercise recovery
After exercise bouts, women are better able to maintain glucose concentrations at sedentary control levels, thus not requiring the counter-regulation of glucose production that is seen in men and requiring less accentuation of lipid metabolism [American Journal of Clinical Nutrition]
Diabetic weight-loss plan yields long-term success
Researchers at the Joslin Diabetes Center report that a 12-week weight-loss program they devised for patients with type 2 diabetes continues to have a positive, long-lasting effect on weight loss 1 year later, long after patients are off on their own [MedlinePlus, USA]
Pathways to Obesity: Are People “Hardwired” to Overeat?
This fact sheet summarizes research on mechanisms that affect overeating but that operate below the level of individual awareness and beyond individual control [RAND, USA]
Food for Thought
Advising people newly diagnosed with diabetes about diet [Journal of Primary Care Nursing, UK]
Type 2 diabetes mellitus: clinical and aetiologic types, therapy and quality of glycaemic control of ambulatory patients
Type 2 diabetes is a heterogeneous disease where clinical judgement alone does not adequately tell the various aetiological types apart without additional laboratory testing of C-peptide levels and GAD antibody status [PubMed]
Folate may protect diabetics’ hearts
A supplement that protects unborn babies from spinal defects may also help shield diabetics from heart problems, Australian research suggests [The Age, Australia]
Diabetic myocardial disease: pathophysiology, early diagnosis and therapeutic options
In this article, we review the possible pathophysiologic mechanisms involved in the development of DMD as well as the structural and functional changes in the diabetic hear [Abstract, Journal of Diabetes and its Complications]
Excess risk of diabetes in persons with hypertension
All persons with hypertension, irrespective of age, sex, and BMI, are at elevated risk of developing diabetes [Abstract, Journal of Diabetes and its Complications]
Dietary antioxidants and glucose metabolism.
Oxidative stress seems to play a pathogenic role in the vicious circle linking obesity, insulin resistance and type 2 diabetes [Abstract, Clinical Nutrition & Metabolic Care]
Neonatal and Late-Onset Diabetes Mellitus Caused by Failure of Pancreatic Development
Report of 4 More Cases and a Review of the Literature [Pediatrics, USA]
Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the DPT1 trial
With the exception of HLA, most susceptibility loci tested condition the risk of autoimmunity rather than the risk of failed immunoregulation that results in islet destruction [Diabetes, USA]
Visceral adiposity found to predict the risk of diabetes
In the lifestyle and the placebo arms, VAT was as effective as WHR and WC in predicting diabetes [American Diabetes Association]
Diabetes-linked A&E admissions up 15%
Diabetic Ketoacidosis (DKA) – a serious complication of Type 1 diabetes – was responsible for 634 emergency admissions to hospital [MHF, UK]
Diabetes centre could help thousands
Volunteers from the South Tyneside branch of Diabetes UK are campaigning for a specialist centre for patients in the borough [The Shields Gazette]
The Missed Patient with Diabetes: How Access to Health Care Affects the Detection of Diabetes
This study examined the association between access to health care and 3 classifications of diabetes status: diagnosed, undiagnosed, and no diabetes [Diabetes Care]
Is insulin advantageous compared with oral anti-diabetic agents in newly diagnosed type 2 diabetes with severe hyperglycemia
A 6-month course of insulin therapy, compared with OAD treatment, could more effectively achieve adequate glycemic control and significant improvement of ß-cell function in new-onset type 2 diabetic patients with severe hyperglycemia [Diabetes Care]
What it all means
Results of the three major clinical trials presented here in recent days have confirmed that in treating diabetes, one size doesn’t fit all [American Diabetes Association]
Glucose and Insulin Measurements from the Oral Glucose Tolerance Test and Mortality Prediction
The steeper rise with age of the OGTT 2-h glucose values and the prognostic primacy of the 120-min glucose value for mortality is consistent with previous reports and suggests the value of using the OGTT in clinical practice [Diabetes Care]
Podcasts
Learn about the latest cure-focused research with these audio reports featuring DRI scientists [Diabetes Research Institute]
Weekly Drug Helps Type 2 Diabetics
Longer-lasting exenatide maintained glucose levels, helped patients lose weight, study reports [MedlinePlus, USA]
Blood test recommended for diabetes screening
Hemoglobin A1c (HbA1c) testing, an indicator of blood sugar levels over the past 3 months, should be used as a screening and diagnostic test for diabetes, an expert panel recommends in an upcoming issue of the Journal of Clinical Endocrinology and Metabolism [MedlinePlus, USA]
Diabetes Education for Children
Due to the heterogeneity of reported diabetes education interventions, outcome measures, and duration of followup, there is insufficient evidence to identify a particular intervention that is more effective than standard care to improve diabetes control or quality of life or to reduce short-term complications [AHRQ, USA]
Safety and efficacy of sitagliptin in patients with type 2 diabetes and chronic renal insufficiency
In this study, sitagliptin was generally well tolerated and provided effective glycaemic control in patients with type 2 diabetes and moderate to severe renal insufficiency, including patients with ESRD on dialysis [Diabetes, Obesity and Metabolism]
One out of four obese school-aged children suffers metabolic syndrome forty years earlier than is typical
It has been revealed in a study carried out by the department chair of the Institute of Food Nutrition and Technology of the University of Granada, Ángel Gil Hernández, who warns that this syndrome provokes arterial hypertension in children, insulin resistance, and, in the long term, type two diabetes [Innovations-Report]
People with Diabetes cannot eat grapes or bananas, or can they?
A snapshot survey by dietitians found that people with diabetes are confused about what foods they can and cannot eat. 2-page PDF [British Dietetic Association]
Chronic Diabetic Complications: The Body’s Adaptive Response to Hyperglycemia Gone Awry?
Here we review the evidence that a maladaptive response to hyperglycemia contributes to diabetic neuropathy, a major microvascular complication. We postulate that the same response may also be the culprit for the other chronic complications of diabetes [American Clinical and Climatological Association]
Diabetes medication associated with slower progression of retina disease
Patients with diabetes who take the medication rosiglitazone may be less likely to develop the eye disease proliferative diabetic retinopathy or to experience reductions in visual acuity [EurekAlert, USA]
Plan to halt gestational diabetes
The three-year, $400,000 project, announced yesterday, will be run by Southern Health, the Jean Hailes Research Team and Monash University. It is one of 10 research projects worldwide funded by the International Diabetes Federation [The Age, Australia]
Weight Gain Decreases Mortality in Patients With Type 1 Diabetes
Gaining body fat may be a good thing for people with type 1 diabetes, say researchers at the University of Pittsburgh Graduate School of Public Health [Doctor’s Guide]
Investigators Predict Shortage of Physicians Who Will Treat Diabetic Patients
A survey of current medical students in the United States found that very few plan to specialize in endocrinology with or without an emphasis on treating diabetes, suggesting that primary care providers will be increasingly tasked with treating the diabetic population [dave+md]
Molecular clocks, type 2 diabetes and cardiovascular disease
Interfering with the environmental Zeitgebers that entrain the central clock may modulate the function of the cell and tissue, with loss of the synchrony that normally exists between the environment and physiology leading to the development of insulin resistance. 7-page PDF [Diabetes and Vascular Disease Research]
Diabetes drug competition in focus at ADA meeting
With an estimated 19 million Americans suffering from Type 2 diabetes, the market for non-insulin diabetes drugs is worth billions and growing [Forbes, USA]
One in 12 will suffer from diabetes by 2025
It is feared that the combination of growing waistbands and couch- potato lifestyles, where we use the car instead of walking even short distances, will see 250,000 people suffering from diabetes in Wales. [icWales, UK]
Four million Britons will have diabetes by 2025
Britain should brace itself for a diabetes “explosion” with the number of people suffering from the disease set to almost double within two decades, new figures released on Monday suggest [Telegraph, UK]
Insulin production found in some people with long-term type 1 diabetes
A significant proportion of people who have had type 1 diabetes for over 50 years may still have the capacity to produce insulin, according to results of a study presented today at the American Diabetes Association 68th Scientific Session [Endocrine Today]
Glucose intolerance sustains carotid plaque inflammation
Carotid plaques in patients with diabetes remain unstable for longer after initial stroke symptoms than do those in patients with normal glucose tolerance, suggest findings from the Oxford Plaque Study [MedWire News ]
Hyperglycemia Lectures Part IV
Part IV of a series of expert lectures on hyperglycemia in the acute care setting by Dr. Nicholas Emanuele, Director of Endocrinology at the Loyola University Chicago School of Medicine [dave+md]
Plasma adiponectin is effective in predicting insulin receptoropathies
Diponectin levels >7 mg/l and <5 mg/l had a 97% positive predictive value and a 97% negative predictive value, respectively, for insulin receptoropathy in severe insulin resistance [American Diabetes Association ]
Finnish Diabetes Risk Score Identifies Benefits of Lifestyle Intervention
The Finnish Diabetes Risk Score (FINDRISC) was effective in identifying high-risk groups that would benefit from intensive lifestyle intervention to prevent type 2 diabetes, according to the results of a randomized controlled trial reported in the May issue of Diabetes Care [Medscape]
Metabolic syndrome and incidence of type 2 diabetes in patients with manifest vascular disease
The high risk of developing type 2 diabetes in patients with established vascular disease underlines the importance of prevention of type 2 diabetes in these patients 9-page PDF [Diabetes and Vascular Disease Research]
Diabetic Control and Risk of Tuberculosis: A Cohort Study
Diabetes mellitus was associated with a modest increase in the risk of active, culture-confirmed, and pulmonary (with or without extrapulmonary involvement) but not extrapulmonary (with or without pulmonary involvement) tuberculosis [American Journal of Epidemiology]
Physician Performance and Racial Disparities in Diabetes Mellitus Care
Racial differences in DM outcomes are primarily related to patients’ characteristics and within-physician effects, wherein individual physicians achieve less favorable outcomes among their black patients than their white patients [Archives of Internal Medicine]
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