Diabetes Multimedia On-Demand Programs
Multimedia educational presentations from (National Diabetes Education Initiative)
The evaluation of metabolic parameters and insulin sensitivity for a more robust diagnosis of the polycystic ovary syndrome
In comparison to healthy women, PCOS women showed increased fasting insulinaemia … evaluation of the metabolic parameters and insulin sensitivity is important for a correct diagnosis of PCOS and a therapeutic approach (Ingenta Connect)
Risk Of Diabetes Mellitus After Extracorporeal Shock Wave Lithotripsy Or Ureteroscopy For Urinary Stone Disease
The fact that this study shows an increased number of URS treatments significantly predicting the onset of diabetes mellitus compared to SWL suggests further prospective studies are indicated to include more detailed history taking such as BMI and other risk factors (Medical News Today, UK)
Diabetes experts respond to new clinical trials
The results of the studies highlight controversy concerning the benefits and risks of tight blood glucose control (AACE)
Does insulin resistance, visceral adiposity, or a sex hormone alteration underlie the metabolic syndrome? Studies in women
Visceral adipose tissue accumulation in women, independently of other measures of adiposity, may largely explain the correlations of insulin, obesity, and sex hormones with risk factors for MI and may be the immediate underlying factor that links risk factors for MI to form the metabolic syndrome (Metabolism)
Permanent Neonatal Diabetes Mellitus Caused by a Novel Homozygous (T168A) Glucokinase (GCK) Mutation: Initial Response to Oral Sulphonylurea Therapy
Sulphonylureas can close the adenosine triphosphate (ATP)-sensitive potassium channel and elicit insulin secretion, but the ATP generated from metabolism is insufficient to fully restore insulin secretory capacity. Nonetheless, sulphonylurea treatment should be tried in patients with GCK-PNDM (Journal of Pediatrics)
Pramlintide May Be Better Choice than Insulin as Mealtime Diabetes Add-on Drug
For diabetic patients recently started on long-acting insulin, mealtime pramlintide (Symlin) may boost blood sugar control similar to rapid-acting insulin but with fewer side effects (Medpage Today – American Diabetes Association)
Exenatide Benefit Not Always Sustained in Type 2 Diabetes
Nearly half of patients taking exenatide (Byetta) for type 2 diabetes for more than a year in a small study discontinued it because of loss of efficacy, although many were combining it with insulin off-label (Medpage Today – American Diabetes Association)
Diabetes Prevention Hopes Revived for Thiazolidinedione
Pioglitazone (Actos) may prevent or delay progression to diabetes for patients with pre-diabetes (Medpage Today – American Diabetes Association)
Human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity
Total muscle ceramide content was similar between individuals showing marked differences in insulin sensitivity, and therefore does not seem to be a major factor in muscle insulin resistance. Furthermore, aerobic capacity does not appear to influence muscle ceramide content (Diabetologia)
Intensification of oxidative stress and inflammation in type 2 diabetes despite antihyperglycemic treatment
Despite sufficient glycemic control using both treatments, some PMNL-related parameters deteriorated. Thus, anti hyperglycemic treatment should be favored due to its combined anti-PMNL priming and anti-inflammatory effect, in addition to its anti-hyperglycemic characteristics (Cardiovascular Diabetology)
Available tools for primary ketoacidosis prevention at diabetes diagnosis in children and adolescents. “The Parma campaign”.
The Parma campaign obtained a reduction in DKA incidence at diabetes diagnosis never found before (Pub Med)
Effects of insulin pump vs. injection treatment on quality of life and impact of disease in children with type 1 diabetes mellitus
Within-patient comparison suggests that metabolic control, frequency of severe hypoglycaemia (a threefold decrease), quality of life and impact of disease scores are improved by pump treatment in comparison to regular treatment with four daily insulin injections (Pediatric Diabetes)
No More Finger Pricks?
Georgetown University, Gentag, Inc. and the Science Applications International Corporation (SAIC) have joined forces to develop a noninvasive method for glucose measurement (Georgetown University, USA)
Severe Insulin Resistance may Increase Rate of Pregnancy and Birth Complications
Testing pregnant women for insulin resistance with a simple blood test may be a new tool for predicting problems during pregnancy, according to a new study (Diabetes Gourmet)
Poor Children More Likely to Develop Diabetes as Adults
Diabetes strikes harder at those who were poor as children, according to a new study that spans more than three decades (Health Behavior News Service)
Insulin resistance means coinfected patients have a poorer response to hepatitis C treatment
Insulin resistance means a poorer response to anti-hepatitis C treatment in HIV/hepatitis C coinfected patients, according to a French study presented to the Fourth International Workshop on HIV and Hepatitis C Coinfection in Madrid (Aidsmap, UK)
Long-term Pesticide Exposure May Increase Risk of Diabetes
Licensed pesticide applicators who used chlorinated pesticides on more than 100 days in their lifetime were at greater risk of diabetes, according to researchers from the (National Institutes of Health, USA)
Management of GI Tract Complications Linked With Diabetes Reviewed CME
As the prevalence of diabetes increases, so do the GI tract complications of diabetes, which are often caused by abnormal GI tract motility (Medscape )
Alcohol Abuse Can Damage The Brain By Decreasing Insulin And Insulin-Like Growth Factor Receptors
During the past several years there has been growing interest in insulin’s effects on brain function. Scientists now believe that deficiencies in insulin, and the loss of brain cells’ ability to respond to insulin, are critical factors leading to neurodegeneration, including Alzheimer’s dementia. Alcohol may exacerbate the problem (Medical News Today, USA)
Diabetes Linked to Depression Risk And Vice Versa
People being treated for type 2 diabetes are at increased risk for depression, according to a new report, and individuals with depression have a moderately increased risk of developing type 2 diabetes (American Diabetes Association)
Maturity-Onset Diabetes of the Young (MODY)
About one to two per cent of people with diabetes have MODY, although it can go unrecognised (JDRF)
Diabetes drug slows early-onset puberty in girls
In young girls at risk of early puberty and insulin resistance, the diabetes drug metformin delayed the onset of menstruation and decreased the development of insulin resistance, a risk factor for type 2 diabetes, according to a new study (EurekAlert)
Waist circumference associated with mortality and prevalence of diabetes
Although no relationship was found between BMI and an increase in mortality rates or prevalence of diabetes, WC significantly correlated with greater mortality and diabetes rates, especially among overweight subjects.(American Diabetes Association)
Inquiry into Obesity in Australia
Submission from Diabetes Australia to the House of Representatives Standing Committee on Health and Ageing. 21-page PDF [Diabetes Australia]
Akesis reports positive results from Phase IIa diabetes study
Akesis Pharmaceuticals has announced positive results of its preliminary analysis from its placebo-controlled Phase IIa trial designed to test the safety and efficacy of AKP-020, a novel vanadium compound, in patients with Type 2 diabetes (Data Monitor)
The Prevalence of a Diabetic Condition and Adhesive Capsulitis of the Shoulder
Previous literature fails to reveal the incidence of newly diagnosed diabetes, 2 of 88 (2%), and prediabetes, 25 of 88 (28.4%) in patients presenting with adhesive capsulitis (Southern Medical Journal, USA)
Herpes May Trigger Unusual Form of Diabetes-study
A common herpes virus might trigger an unusual form of type 2 diabetes found in sub-Saharan Africa that is characterised by rapid onset of disease (American Diabetes Association)
New website for young adults with diabetes
Diabetes UK has launched a new website dedicated to young adults with diabetes [Diabetes, UK]
New research claims link between diabetes and hearing loss
New research claims that adults with diabetes are twice as likely to have impaired hearing as people without the condition [Diabetes, UK]
Data from Phase III study comparing liraglutide to exenatide in type 2 diabetes
Novo Nordisk have released results from a Phase III study (LEAD 6) comparing the two GLP-1 analogues liraglutide and exenatide in the treatment of individuals with type 2 diabetes [NeLM, UK]
Putting blood glucose control in type 2 diabetes into perspective
Intensive strategies to achieve tighter blood glucose control do not improve cardiovascular outcomes in type 2 diabetes and can be harmful [National Prescribing Centre blog, UK]
Metabolic Phenotypes, Vascular Complications and Premature Deaths in a Population of 4,197 Patients with Type 1 Diabetes
The results also suggest that diabetes per se, without an adverse metabolic phenotype, does not contribute to increased mortality [PubMed]
Risks for type-2 diabetes associated with the metabolic syndrome
Subjects with MS were at a higher risk of developing T2DM than those who did not have the syndrome. Also IFG was found to be an excellent predictor of T2DM. However, there was not a significant interaction between IFG and the other MS components [Diabetes Research and Clinical Practice]
Cornell researcher strives to break the link between obesity and diabetes
Finding just the right gene could do it, says Qi, an assistant professor of nutritional sciences in the College of Human Ecology [Cornell University, USA]
Abbott Nutrition Introduces New Web-Based Lifestyle Program for People with Diabetes
Study Finds People With Diabetes Have Better Health Outcomes After Participating In A Total Diabetes Management Program [CNW]
Biphasic insulin aspart 30 treatment in patients with type 2 diabetes poorly controlled on prior diabetes treatment: results from the PRESENT study
According to this observational study, in clinical practice, initiating or transferring uncontrolled patients to biphasic insulin aspart improved glycaemic control without using a strict insulin algorithm [PubMed]
GAG urinary excretion directly associated with diabetic nephropathy
The authors suggest that the assessment of urinary GAG excretion may be effective in the diagnosis of early stages of diabetic nephropathy [American Diabetes Association]
Preterax treats type 2 diabetes and kidney damage
Preterax reduces the likelihood of new or worsening nephropathy in patients with type 2 diabetes mellitus and can lead to nepropathy regression in those with existing kidney damage [Pharmacy Europe]
Diabetes ‘time bomb’ could be defused by 2030
Pharmacists to play a key role in finding people with diabetes and delivering better prevention and treatment [School of Pharmacy, University of London, UK]
Cheap diabetes screening could save many lives
Diabetes UK Scotland agreed with Prof Clark, saying that testing could provide a decade of warning to those at risk [Diabetes UK]
Prediabetes rate soars in children, research shows
One in four obese children in Canada who sees a doctor for weight issues has prediabetes [Vancouver Sun, Canada]
Younger age of type 2 diabetes onset increases the risk of retinopathy
In view of these results, the authors recommend a close follow-up and control of young patients with type 2 diabetes [American Diabetes Association]
Physiological Role of C-Peptide in Patients with Diabetes Mellitus [9 articles]
[Experimental Diabetes Research]
Impact of hormone replacement therapy on exercise training–induced improvements in insulin action in sedentary overweight adults
In summary, in an ET intervention, HRT use appears to be associated with more robust responses in insulin action [Metabolism]
Insulin lispro found safe and effective in diabetic pregnant women
These results indicate that insulin lispro is safe and effective for pregnant women with diabetes [American Diabetes Association]
Association of Brominated Flame Retardants with Diabetes and Metabolic syndrome in the United States Population: 2003-2004
Pending confirmation in prospective studies, lipophilic xenobiotics including brominated POPs stored in adipose tissue may be involved in the pathogenesis of diabetes and metabolic syndrome [Diabetes Care]
How to avoid type 2 diabetes
A film about the louche life of Dylan Thomas is also a timely warning about diabetes [Times, UK]
The Fatty-Acid Receptor GPR40 Plays a Role in Insulin Secretion In Vivo After High-Fat Feeding
GPR40 plays a role not only in fatty-acid modulation of insulin secretion, but also in GSIS after high-fat feeding. These observations raise doubts on the validity of a therapeutic approach based on GPR40 antagonism for the treatment of type 2 diabetes [Diabetes]
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