Diabetes: the silent pandemic and its impact on Australia
Data from 2010 show that only about half of Australians with diabetes were achieving adequate control of their blood glucose levels. Poor control of blood glucose means a higher risk of developing diabetes complications – Researched and written by Baker IDI Heart and Diabetes Institute
A pilot test of a tailored mobile and web-based diabetes messaging system for adolescents
The results demonstrate the feasibility of the messaging system, user acceptance and a promising effect on glycaemic control. Integrating this type of messaging system with online educational programming could prove to be beneficial (Journal of Telemedicine and Telecare)
Effect of exenatide on the pharmacokinetics of a combination oral contraceptive
The observed reduction in Cmax is likely of limited importance given the unaltered oral contraceptive bioavailability and trough concentrations; however, for oral medications that are dependent on threshold concentrations for efficacy, such as contraceptives and antibiotics, patients should be advised to take those drugs at least 1 hour before exenatide injection (BMC Clinical Pharmacology)
Oral contraception enhances growth hormone responsiveness to hyper- and hypoglycaemia
Given the known boosting effects of growth hormone on hypoglycaemic hormonal counter-regulation, oral contraceptives may thus be a pharmacological candidate contributing to combat hypoglycaemia unawareness in women with diabetes in the future (Diabetic Medicine)
Platelet Isoprostane Overproduction in Diabetic Patients Treated With Aspirin
These findings suggest that in aspirin-treated diabetic patients, oxidative stress–mediated platelet isoprostane overproduction is associated with enhanced platelet recruitment, an effect that mitigates aspirin-mediated TxA2 inhibition (Diabetes)
Long-Term Efficacy of Dapagliflozin in Patients With Type 2 Diabetes Mellitus Receiving High Doses of Insulin
Dapagliflozin improves glycemic control, stabilizes insulin dosing, and reduces weight without increasing major hypoglycemic episodes in patients with inadequately controlled type 2 diabetes mellitus (Annals of Internal Medicine)
Relationship Between Glycosylated Hemoglobin Assessment and Glucose Therapy Intensification in Patients With Diabetes Hospitalized for Acute Myocardial Infarction
Long-term glucose control is poor in most AMI patients with DM, but only a minority of patients undergo GTI at discharge. Inpatient A1C assessment is strongly associated with intensification of glucose-lowering therapy (Diabetes Care)
Effects of some anti-diabetic and cardioprotective agents on proliferation and apoptosis of human coronary artery endothelial cells
Our results suggest that the anti-diabetic and cardioprotective agents mentioned above have direct and beneficial effects on endothelial cell viability, regeneration and apoptosis. This may add yet another valuable property to their therapeutic effect, increasing their clinical utility in type 2 diabetic patients in whom endothelial dysfunction is a prominent feature that adversely affect their survival (Cardiovascular Diabetology)
Impact of insulin pumps on glycaemic control in a pump-naïve paediatric regional population
In a pump-naïve regional paediatric population, insulin-pump therapy for T1DM was safe and effective, and associated with sustained improvements in HbA1c and lower risk of hypoglycaemia (Journal of Paediatrics and Child Health)
A globally applicable screening model for detecting individuals with undiagnosed diabetes
We identified a globally applicable screening model to detect individuals at high risk of undiagnosed diabetes. The model performed well in most geographical regions, is simple and requires no calculations. This global screening model may be particularly helpful in developing countries with no population based data with which to develop own screening models (Diabetes Research and Clinical Practice)
Diabetes Products Proposals
Proposed changes to funded diabetes management products (PHARMAC, New Zealand)
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