Everyone aged between 40-74 in England will begin to be invited for a free health check as part of a national programme to identify their risk of diseases such as coronary heart disease, stroke, diabetes and kidney disease (DoH)
Counterfeit NovoFine® needles discovered in England
Novo Nordisk and the Medicines and Healthcare products Regulatory Agency (MHRA) in the UK are warning the public and healthcare professionals about the discovery of a small number of counterfeit NovoFine® needles on the UK market (JDRF)
The effect of glycaemic control on the quantitative characteristics of retinopathy lesions in patients with type 2 diabetes mellitus: 10-year follow-up study
The 2-hour post-load glucose at 5-year measurement appears to be the most reliable parameter predicting 10-year DR lesions (Graefe’s Archive for Clinical and Experimental Ophthalmology)
CPS to review insulin death case
A file on a nurse who mistakenly gave a diabetic woman, aged 85, a lethal dose of insulin is to be reopened (BBC)
Amylin and Lilly to file Byetta LAR before the end of June
Amylin, Eli Lilly and Alkermes say they will soon file their once-weekly version of the diabetes blockbuster Byetta and have presented data on the standard drug which showed no increased risk of cardiovascular events (PharmaTimes)
Improvement of the diabetic foot upon testosterone administration to hypogonadal men with peripheral arterial disease
Beneficial effects of administration of testosterone to hypogonadal with a diabetic foot may be due to improved vascularization and to anti-inflammatory action (Cardiovascular Diabetology)
The impact of topical phenytoin on recalcitrant neuropathic diabetic foot ulceration.
Topical phenytoin can enhance wound healing in recalcitrant neuropathic diabetic foot ulcers, although only one-quarter of patients achieved more than 50% reduction in ulcer size after eight weeks of therapy (Journal of Wound Care – via PubMed)
Early Metabolic Markers of Islet Allograft Dysfunction
The intravenous glucose tolerance test and mixed meal tolerance test may be useful in the prediction of IGD and should be essential components of the metabolic testing of islet transplant recipients (Transplantation)
Depressive symptoms are associated with physical inactivity in patients with type 2 diabetes
Presence of depressive symptoms almost doubles the likelihood of physical inactivity in patients with type 2 diabetes. Longitudinal studies are needed to investigate whether physical inactivity forms the link between depression and poor disease outcomes (Family Practice)
Lilly, Amylin’s Byetta Analysis Finds No Heart Risks
The data will be used to support the safety of a once- weekly form of Byetta, which is now given twice a day, the companies said today in a statement (Bloomberg)
Novo Nordisk’s Drug May Avoid Takeda’s FDA Travails
Novo Nordisk A/S may catch a lucky break in its pursuit of U.S. approval for the diabetes drug liraglutide, its most important product in development with potential sales of $1 billion (Bloomberg)
Intensive versus Conventional Glucose Control in Critically Ill Patients
In this large, international, randomized trial, we found that intensive glucose control increased mortality among adults in the ICU: a blood glucose target of 180 mg or less per deciliter resulted in lower mortality than did a target of 81 to 108 mg per deciliter (NEJM)
Joint Statement from ADA and AACE on the NICE-SUGAR Study on Intensive Versus Conventional Glucose Control In Critically Ill Patients
The American Diabetes Association (ADA) and the American Association of Clinical Endocrinologists (AACE) maintain that the findings of the Normoglycemia in Intensive Care Evaluation-Survival Using Glucose Algorithm Regulation (NICE-SUGAR) study should NOT lead to an abandonment of the concept of good glucose management in the hospital setting (American Diabetes Association)
Early nephropathy in type 1 diabetes: the importance of early renal function decline
The results of recent clinical trials in early diabetic nephropathy demonstrate that current therapies designed to suppress microalbuminuria do not prevent renal function decline. However, recent observational studies refined the traditional model of early nephropathy in type 1 diabetes and may inform more effective therapies for the prevention of chronic kidney disease (Current Opinion in Nephrology and Hypertension)
Predictors of Metabolic Control among Adolescents with Diabetes: A 4-Year Longitudinal Study
Independent risk factors for poor metabolic control included poor self-care, disturbed eating behavior, depression, and peer relations; parental support was an independent resistance factor for girls. Future research should examine mechanisms by which these relations emerge (Journal of Pediatric Psychology)
Intensive therapy for diabetes through influence on innate immune system
We speculate that the effects on the innate immune system through pharmacologic therapy or lifestyle modification such as exercise training are able to account – at least amongst others – for carry-over beneficial effects of multifactorial intervention on insulin resistance and type 2 diabetes (Medical Hypotheses)
Adipokines in the treatment of diabetes mellitus and obesity
This review describes the role of adipokines in generating insulin resistance and the chronic low-grade inflammatory profile accompanying visceral obesity (Informa)
Oramed Pharmaceuticals to Present Oral Insulin Phase 2A Trial Results at the Upcoming Annual Meeting of the ADA
Oramed Pharmaceuticals, Inc. has been selected to present the results from the study, entitled, “Open Label Study to Assess the Safety, Pharmacokinetics and Pharmacodynamics of Oral Insulin Formulations in Subjects with Type 2 Diabetes ” at the upcoming 69th Annual American Diabetes Association’s Scientific Sessions Conference in New Orleans (Oramed Pharmaceuticals)
Biodel shares jump on plans to submit NDA for diabetes drug
Shares of Biodel Inc. jumped as much as 38 percent on Wednesday, a day after the company said it plans to submit a new drug application for its experimental diabetes drug VIAject, removing some of the uncertainty over the drug’s prospects (Forbes)
Antibiotic Use and Type 1 Diabetes in Childhood
In a large nationwide prospective study, no association between antibiotic use and type 1 diabetes was found among Danish children (American Journal of Epidemiology)
Brain glucose metabolism difference between bipolar and unipolar mood disorders in depressed and euthymic states
The results of this study provide evidence of persistent hypometabolism in depressed mood disorder patients, particularly in the frontal gyrus (Progress in Neuro-Psychopharmacology and Biological Psychiatry)
Glucose Control in the ICU — How Tight Is Too Tight?
In retrospect, it may turn out that we have been overly enthusiastic in our attempts to attain euglycemia during critical care – Editorial (NEJM)
Intensive versus Conventional Glucose Control in Critically Ill Patients
In this large, international, randomized trial, we found that intensive glucose control increased mortality among adults in the ICU (NEJM)
Long-term Effects of Metformin on Metabolism and Microvascular and Macrovascular Disease in Patients With Type 2 Diabetes Mellitus
Metformin, added to insulin in patients with DM2, improved body weight, glycemic control, and insulin requirements but did not improve the primary end point (Archives of Internal Medicine)
On demand doctor’s appointments do not improve diabetes care
Same-day medical scheduling, also known as on demand scheduling, does not improve care of chronically ill individuals, according to a study of 4,060 adult patients with diabetes (EurekAlert)
Gestational diabetes; can a low glycemic index diet reduce the need for insulin? A randomised trial
Using a low GI diet for women diagnosed with GDM effectively halved the number needing to use insulin with no compromise of obstetric or fetal outcomes (Diabetes Care)
Metabasis Therapeutics Announces Positive Results in a Clinical Trial of MB07803 in Patients with Poorly Controlled Type 2 Diabetes
In the trial, MB07803 treatment resulted in dose-related, clinically meaningful and statistically significant reductions in day long glycemia (24-hour weighted mean glucose levels) at all doses evaluated (50 mg, 200 mg and 400 mg, twice-daily) (PharmaLive)
SemBioSys Genetics Inc. Announces Clinical Results with Plant-Produced Insulin
The trial demonstrated that SBS-1000 was bioequivalent to a recombinant human insulin with the expected safety profile (PharmaLive)
Body mass index and risk of all-cause and cardiovascular mortality in hospitalized elderly patients with diabetes mellitus
In very elderly subjects with diabetes mellitus, increased BMI was associated with reduced mortality risk (Diabetic Medicine)
Insulin Pen Instead of Syringe Saves Hospital Bills For Type 2s
In a study funded by Novo Nordisk, researchers at Ohio State University have found that type 2s who move from oral meds to insulin would be wise to start with an insulin pen rather than a syringe (Diabetes Health)
The QDScore diabetes risk calculator
You can use this calculator to work out your risk of developing Type 2 Diabetes over the next ten years by answering some simple questions (QDScore)
Decreased levels of metabolic enzymes in pancreatic islets of patients with type 2 diabetes
Low levels of certain islet metabolic enzymes, especially mitochondrial enzymes, are associated with human type 2 diabetes (Diabetologia)
Effect of moderate alcoholic beverage consumption on insulin sensitivity in insulin-resistant, nondiabetic individuals
These data demonstrate that 8 weeks of moderate alcohol consumption had minimal impact on enhancing insulin sensitivity in nondiabetic, insulin-resistant individuals, raising questions as to the role, if any, of improved insulin sensitivity in the purported clinical benefits associated with moderate alcohol consumption (Metabolism)
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