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Diabetes News November 12th 2009

November 12th 2009

This edition of Glycosmedia is sponsored by Oxford University Press
A selection of books from Oxford University Press:

Diabetes

Diabetes Care – A Practical Manual

Oxford Handbook of Endocrinology and Diabetes

Oxford Handbook of Diabetes Nursing

Diabetes: The Biography

World Diabetes Day – November 14
The World Diabetes Day campaign is led by the International Diabetes Federation (IDF) and its member associations. It engages millions of people worldwide in diabetes advocacy and awareness (World Diabetes Day)

World Diabetes Day videos launched on YouTube
The International Diabetes Federation has just launched two short videos setting the stage for World Diabetes Day on 14 November (World Diabetes Day)

2009 Annual Evidence Update on Diabetes
Results of our third Annual Evidence Update which identifies new systematic reviews on diabetes published between September 2008 and September 2009 (NHS Evidence – Diabetes )

EFSD/Novo Nordisk partnership for diabetes research in Europe
The European Foundation for the Study of Diabetes (EFSD), the research Foundation of EASD, and Novo Nordisk are pleased to announce their support of diabetes research with the contribution of 3 million euros over the next three years (Novo Nordisk)

Computer device ‘helps’ diabetics
A handheld computer console game has been developed to help diabetic children monitor their condition (BBC, UK)

Research matters
Download of the latest issue – Research matters Autumn 2009 (Diabetes, UK)

Prediction of Coronary Heart Disease Risk in a General, Pre-Diabetic, and Diabetic Population During 10 Years of Follow-up
The use of the Framingham function for prediction of the first CHD event is likely to overestimate an individual’s absolute CHD risk. In CHD prevention, application of the SCORE and UKPDS functions might be useful in the absence of a more valid tool (Diabetes Care)

No Benefits of Aspirin for Primary Prevention in Diabetics, Meta-Analysis Suggests
Another meta-analysis–this one focused on diabetics–is questioning the role of aspirin for the primary prevention of cardiovascular events (Medscape)

Successes and challenges of insulin therapy for type 2 diabetes in a managed-care setting
Insulin is effective when used per ADA-EASD guidelines but health plans wishing to optimize diabetes care may need to intensify insulin therapy or consider the use of adjunct therapies in the years after initiation (Current Medical Research and Opinion)

Alogliptin added to insulin therapy in patients with type 2 diabetes reduces HbA1c without causing weight gain or increased hypoglycaemia
Adding alogliptin to previous insulin therapy (with or without metformin) significantly improved glycaemic control in patients with type 2 diabetes inadequately controlled on insulin, without causing weight gain or increasing the incidence of hypoglycaemia (Diabetes, Obesity and Metabolism)

Patient-reported outcomes in a survey of patients treated with oral antihyperglycaemic medications:
Among patients with type 2 diabetes treated with OAHAs, self-reported hypoglycaemia and weight gain were associated with decreased treatment satisfaction and HRQoL. In addition, the presence of these SEs was associated with increased fear of hypoglycaemia (Diabetes, Obesity and Metabolism)

FDA Working to Revise Prescribing Information for Diabetes Medications
The FDA is revising the prescribing information for the injectable diabetes medication exenatide and the oral diabetes drug sitagliptin phosphate following reports of renal problems associated with exenatide use, as well as reports linking sitagliptin use with pancreatitis (AAFP)

Free Diabetes UK ‘Diabetes Care and You’ leaflets for GPs and their patients
Diabetes UK, in partnership with NHS Diabetes, has produced ‘Diabetes Care and You’ – a booklet to provide key information to people with diabetes about their role in managing their diabetes, working together with their healthcare team, and what they should expect from the NHS Free download (Diabetes UK)

Diabetes and obesity in older adults: a call to action
This call to action discusses comorbidities associated with type 2 diabetes and obesity in the older population and its impact on patients (Reviews in Clinical Gerontology)

A ‘radical’ new rural model for pediatric diabetes care
Multidisciplinary child diabetes care can be successfully achieved in rural settings using local resources with results comparable to international tertiary multidisciplinary diabetes units (Pediatric Diabetes)

Saxagliptin Added to a Thiazolidinedione Improves Glycemic Control in Patients with Type 2 Diabetes and Inadequate Control on Thiazolidinedione Alone
Saxagliptin added to TZD provided statistically significant improvements in key parameters of glycemic control vs. TZD monotherapy and was generally well tolerated (Journal of Clinical Endocrinology & Metabolism)

Effect of Rosiglitazone, Metformin, and Glyburide on Bone Biomarkers in Patients with Type 2 Diabetes
Commonly measured bone biomarkers suggest that changes in bone resorption may be partly responsible for the increased risk of fracture in women taking thiazolidinedione (Journal of Clinical Endocrinology & Metabolism)

Sodium Glucose Cotransporter 2 Inhibitors as a New Treatment for Diabetes Mellitus
SGLT2 inhibitors are showing promise as a useful addition to the current therapeutic options in type 2 diabetes mellitus. Results of ongoing phase III clinical trials are awaited and will determine whether the risk-benefit ratio will allow approval of this new class of drug for the management of type 2 diabetes mellitus (Journal of Clinical Endocrinology & Metabolism)

Pilot Evaluation of a Prototype Critical Care Blood Glucose Monitor in Normal Volunteers
Automated phlebotomy can be performed in healthy subjects using this prototype BG monitor. The BG measurement technology had suboptimal accuracy based on a YSI reference. A more accurate BG point-of care testing meter and strip technology have been incorporated into the future version of this monitor (Journal of Diabetes Science and Technology)

The Impact of Diabetes Type 2 in the Pathogenesis of Benign Prostatic Hyperplasia: A Review
The exact relationship of BPH to diabetes remains unclear. The specific pathway interfering in the development of both conditions is still poorly investigated. However, evidence suggests that an association between BPH and diabetes through a common pathogenic mechanism through male hormone activity alteration mediated by IGF is possible (Advances in Urology)

Software for transfer of data between diabetic retinal screening services and hospital eye services
Digital Healthcare, the leading supplier of software to UK diabetic retinal screening services (DRSS) and Medisoft, a leading supplier of software to UK hospital eye services (HES), are collaborating to develop Medisoft Connector, a software module that will allow the two-way transfer of patient and outcome data between their respective systems (British Journal of Healthcare Computing & Information Management)

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