Diabetes News November 1st 2009

Depression with a chronic physical health problem
The treatment and management of depression in adults with chronic physical health problems (NICE, UK)

New guidance on diabetes and depression
The National Institute for Health and Clinical Excellence (NICE) has published guidance on the treatment and management of depression in adults with chronic physical health problems, including diabetes, heart disease and cancer (Diabetes UK)

Clinical Knowledge Summaries – Management of Diabetes Type 2
Clinical Knowledge Summaries (formerly PRODIGY) are a reliable source of evidence-based information and practical ‘know how’ about the common conditions managed in primary care (CKS, NHS)

Fear of hypoglycaemia
Defining a minimum clinically important difference in patients with type 2 diabetes (Health and Quality of Life Outcomes)

Mitochondrial Function and Insulin Resistance in Overweight and Normal-Weight Children
Reduced skeletal muscle mitochondrial oxidative phosphorylation, assessed by PCr recovery, is associated with insulin resistance and an altered metabolic phenotype in children (Journal of Clinical Endocrinology & Metabolism)

Modern insulins drive up Novo Nordisk earnings
Growth was driven by Novo’s diabetes division, where turnover climbed 12% to 9.27 billion kroner (PharmaTimes)

Sanofi-Aventis and Wellstat Therapeutics Enter into an Exclusive Worldwide Licensing Agreement for Novel Oral Agent to Treat Type II Diabetes
Under this agreement, sanofi-aventis will receive an exclusive worldwide license to develop, manufacture and commercialize PN2034 and related compounds (PharmaLive)

Exploring the complex care of the diabetic foot ulcer
Diabetic foot ulcers are a complication affecting approximately 15% of people with diabetes. Treating these ulcers is costly, and the resulting disfigurement can be devastating (JAAPA)

Oxidative Stress Markers Regulating the Healing of Foot Ulcers in Patients With Type 2 Diabetes
A high level of lipid peroxidation accompanied by insufficient antioxidant enzymes and decreased total antioxidant status in plasma could contribute to the chronicity of an ulcer and an extended inflammatory reaction. Thus, oxidative stress may be regarded as an important factor for nonhealing diabetic foot ulcers among patients with type 2 diabetes (Wounds)

Measuring and estimating insulin resistance in clinical and research settings
This article covers several important issues on the measurement of insulin secretion and resistance that had not been well described in other review articles, and may be of help for future clinical investigation (NMCD)

Decisions About Intensity of Glycemic Control Should Depend on Age and Functional Status
Decisions about intensive glycemic control in older adults should consider life expectancy, which can be assessed based on age and functional status. Older adults with limited life expectancy are unlikely to benefit from intensive control compared with moderate control (Clinical Diabetes)

Factors Predictive of Use and of Benefit From Continuous Glucose Monitoring in Type 1 Diabetes
Frequency of blood glucose meter monitoring and initial CGM use may help predict the likelihood of long-term CGM benefit in intensively treated patients with type 1 diabetes of all ages (Diabetes Care)

Three-Year Efficacy of Complex Insulin Regimens in Type 2 Diabetes
Patients who added a basal or prandial insulin-based regimen to oral therapy had better glycated hemoglobin control than patients who added a biphasic insulin-based regimen (NEJM)

Network of vascular diseases, death and biochemical characteristics in a set of 4,197 patients with type 1 diabetes
The complex pattern of links between diverse characteristics and the lack of a single dominant factor suggests a need for multifactorial and multidisciplinary paradigms for the research, treatment and prevention of diabetic complications (Cardio Vascular Diabetology)

Dieting ‘keeps diabetes at bay’
A period of careful eating and regular exercise can stave off diabetes for a decade, a study suggests (BBC, UK)

Diabetes to hit one in seven
One in seven Australians is forecast to have type 2 diabetes in 2050, at a cost of $14 billion in today’s terms, the National Centre for Social and Economic Modelling predicts (The Age, Australia)