Appropriate advancement of type 2 diabetes therapy
An editorial workgroup meeting consisting of a multidisciplinary panel of diabetes thought leaders recently convened to provide additional insight on these issues. Their recommendations and viewpoints are reported in this supplement (Current Clinical Practice)
Oramed Pharmaceuticals Launches Phase 1A Trials of its InsulinSuppository
An insulin suppository represents an important development in the treatmentof diabetes as it provides a painless alternative for effective insulin delivery (Oramed)
Novo taps stem cells in hunt for diabetes cure
The world leader in diabetes care said on Thursday it had launched a new collaboration to develop a treatment for type 1 diabetes by programing stem cells to turn into insulin-producing cells (Reuters)
Forest Laboratories, Inc.and Phenomix Corporation in $340 Million Diabetes Deal
Announcing that they have entered into a definitive collaboration agreement to develop and commercialize dutogliptin (BioSpace)
Hypoglycemia
This article is the 8th in a 12-part series reviewing the fundamentals of diabetes care for physicians in training (Clinical Diabetes)
Tougher diabetes targets will ‘neglect highest risk patients’
The decision to toughen up the QOF diabetes targets has sparked a row between experts amid claims that GPs will be forced to ‘concentrate their efforts in the wrong place’ (Pulse, UK)
Physical Activity May Facilitate Diabetes Prevention in Adolescents
These results suggest that moderate activity may be beneficial in the prevention of diabetes in adolescent populations both through promoting efficient glucose disposal and through increasing energy expenditure (Diabetes Care)
American Diabetes Association, European Association for the Study of Diabetes Publish Consensus Algorithm for Type 2 Diabetes Treatment
The revisions to the diabetes treatment algorithm, first published in 2006, provide guidance to health care providers for treating type 2 diabetes, taking into account new medications that have come on the market and the most current scientific data regarding previously recommended drugs (Market Watch)
Novel Insulin Formulation Provides for Glucose-regulated Insulin Delivery
SmartCells, Inc. and Juvenile Diabetes Research Foundation Announce Partnership and $1 Million Funding to Advance SmartInsulin(TM) for Type 1 Diabetes (Market Watch)
Seattle, Swedish researchers working on diabetes vaccine
Video – Are we close to preventing Type 1 diabetes? A vaccine may not be far off. Researchers from Sweden are in Seattle this weekend to announce their findings on a promising new study (King5, USA)
Thiazolidinediones are partial agonists for the Glucocorticoid Receptor
Both Ciglitazone and Pioglitazone, structurally related to Rosiglitazone, show similar effects on the Glucocorticoid Receptor (Endocrinology)
Aussies to flock to NZ for diabetes trial
Hundreds of Australians with Type 1 diabetes are trying to join a clinical trial in New Zealand which will see human patients injected with pig cells (ABC, Australia)
Year of Care Practical Guide
The Year of Care programme, a joint venture supported by Diabetes UK, NHS National Diabetes Support Team, Department of Health and the Health Foundation, has published “Getting to Grips with the Year of Care: A Practical Guide” 47-page PDF (NDST)
Management of cardiovascular disease in patients with diabetes: the 2008 Canadian Diabetes Association guidelines
Because cardiovascular disease is the main cause of mortality among diabetic patients, managing cardiovascular risk should be a key treatment goal for providers and patients (Canadian Medical Association)
Diabetes mellitus, exocrine pancreatic deficiency, hypertrichosis, hyperpigmentation, and chronic inflammation: confirmation of a syndrome
The presence of consanguinity in the parents and similarity of clinical features in the siblings are suggestive of a novel autoimmune disorder, possibly secondary to autosomal recessive inheritance (Pediatric Diabetes)
New Zealand to transplant pig cells into humans against diabetes
New Zealand has given the go-ahead to a controversial clinical trial involving the transplantation of insulin-producing pig cells into humans to treat type-1 diabetes (Telegraph, UK)
Boehringer in type-two diabetes drug development
The company has unveiled a pipeline of novel oral antidiabetic compounds which are at the phase-two and phase-three stage of clinical testing (HAYS Pharma)
Amylin Gets $125M from Eli Lilly To Make Once-Weekly Diabetes Drug
Amylin Pharmaceuticals said today it has scored a $125 million cash payment from Eli Lilly to manufacture a once-weekly injectable version of exenatide for diabetes (Xconomy)
Diabetes growth doubles in a year
The number of people diagnosed with diabetes in the UK has risen by more than 167,000 since last year, bringing the total diabetes population to almost 2.5 million according to new data from GP practices (Diabetes UK)
New Guidelines set to help improve services for adults with diabetes
Health Minister Edwina Hart has today unveiled new guidelines that form part of a delivery strategy for the management of adults with diabetes in Wales (Welsh Assembly Government, UK)
Screening for type 2 diabetes: A randomised controlled trial in British general practice
Screening for type 2 diabetes in primary care is feasible but may be associated with higher levels of short-term anxiety among invited compared with non-invited participants (BMC Public Health)
Surgery offers best diabetes care in the country
The practice has received an award from Health Secretary Alan Johnson after scoring the highest marks nationally for its service (Salisbury Journal, UK)
Improved survival in both men and women with diabetes between 1980 and 2004 – a cohort study in Sweden
Survival rates have improved in subjects with diabetes since the early 1980s, more so in women than in men, thereby decreasing the gap to non-diabetic women (Cardiovascular Diabetology )
Relationship between beta-cell mass and diabetes onset
The relative contribution of beta-cell loss versus beta-cell dysfunction to diabetes onset remains an area of controversy. However, because cytotoxicity sufficient to induce beta-cell apoptosis predictably disturbs beta-cell function, it is naive to attempt to distinguish the relative contributions of these linked processes to diabetes onset (PubMed)
High levels of adiponectin reduce the risk of type 2 diabetes in women
Elevated concentrations of total and high-molecular-weight adiponectin inversely and strongly correlated with a substantially reduced risk for diabetes (American Diabetes Association)
Daily drug helps diabetes patients
Patients given a daily dose of liraglutide, a human GLP-1 analogue, achieved better blood glucose control than those treated with exenatide, a GLP-1 mimetic administered twice daily (Pharmacy Europe)
Aspirin or antioxidants of no benefit in primary prevention of cardiovascular events and mortality in diabetic patients
Findings from the POPADAD (prevention of progression of arterial disease and diabetes) study have been published early online in the BMJ (National elctronic Library for Medicines, NHS, UK)
Aspirin use in people with diabetes
Behind the headlines (NHS Choices)
Effect of metformin in patients with type-1 diabetes and persistent inadequate glycaemic control
The researchers conclude that though adjunct metformin did not improve glycaemic control in patients with poorly controlled type 1 diabetes, it was linked to reductions of insulin dose and body weight (National elctronic Library for Medicines, NHS, UK)
Effectiveness of continuous glucose monitoring in pregnant women with diabetes: randomised clinical trial
Continuous glucose monitoring during pregnancy is associated with improved glycaemic control in the third trimester, lower birth weight, and reduced risk of macrosomia (BMJ, UK)
Commentary: The technology of continuous glucose monitoring
Continuous glucose monitoring “fleshes out” the information obtained from conventional self monitored glucose readings, helping inform changes to management and providing a graphic educational tool (BMJ, UK)
Obesity in children. Part 1: Epidemiology, measurement, risk factors, and screening
Modifiable risk factors for childhood obesity are maternal gestational diabetes; high levels of television viewing; low levels of physical activity; parents’ inactivity; and high consumption of dietary fat, carbohydrate, and sweetened drinks (BMJ, UK)
Warning as Welsh diabetes figures grow by 10,000
Dai Williams, Diabetes UK Cymru’s national director, said: “There is no getting away from the fact that the growth of diabetes is linked to the obesity crisis (Wales Online, UK)
Are the adverse effects of glitazones linked to induced testosterone deficiency?
This hypothesis explains the adverse effects of glitazones on the heart and other organs by reducing androgen action in directing stem cells differentiation into myocytes, vascular endothelium, erythroid stem cells and osteoblasts, and promoting adipocyte differentiation (Cardiovascular Diabetology)
Recent and emerging anti-diabetes targets
A panel of 20 emerging diabetes targets is presented, and small molecule modulators for each target will be discussed (Medicinal Research Reviews)
Effects of a telephone intervention in patients with type 2 diabetes
These results demonstrate that a telephone intervention can increase physical activity and reduce cardiovascular risk factors. As a result it may reduce health care-related costs (PubMed)
2008 Type 2 Update report
On current trends by 2022 the total number of people with Type 2 diabetes is expected to be at least 407,000. This is more than 150,000 (60%) above the prediction based on the 2001 prevalence. Forecast levels are increasing all the time because actual experience is proving to be well above forecasts (Diabetes New Zealand)
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