Gene expression changes in cancellous bone of type 2 diabetics: a biomolecular basis for diabetic bone disease

This study identifies considerable changes in the expression of transcription factors and extracellular matrix (ECM) components of bone in 2DM patients. Furthermore, the analysis of key differentiation factors of osteoblasts revealed significant alterations in gene expression of these factors, which may contribute to the dysregulation of energy metabolism in 2DM (Langenbeck’s Archives of Surgery)