Oral insulin (ORMD-0801) induced greater reductions in HbA1c when compared to placebo and was safe and well-tolerated in individuals with uncontrolled T2DM (Institute of Endocrinology, Metabolism & Hypertension )
Diabetes News
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Care processes in people in remission from type 2 diabetes: A cohort study using the National Diabetes Audit
People coded with remission of type 2 diabetes were less likely to receive diabetes care processes than those without such coding (Diabetic Medicine)
Effects of Intensive Blood Pressure Lowering in Patients with Diabetes: A Pooled Analysis of the STEP and ACCORD-BP Randomized Trials
An intensive SBP lowering target of 110 to <130 mmHg reduces the cardiovascular outcomes compared with a standard SBP lowering target of 130 to <150 mmHg. The findings of this study support the favorable effects of intensive SBP lowering in hypertensive patients with diabetes (Diabetes, Obesity and Metabolism)
An Indirect Comparison of Basal Insulin Plus Once-Weekly Semaglutide and Fully Optimised Basal–Bolus Insulin in Type 2 Diabetes
In T2D uncontrolled by basal insulin, intensification with semaglutide 1.0 mg OW was associated with better glycaemic control, weight loss, and reduced hypoglycaemia versus a basal–bolus regimen, while limiting the treatment burden associated with frequent injections. Clinicians could consider treatment intensification with semaglutide when T2D is uncontrolled by basal insulin, especially when weight management is a priority (Diabetes Therapy)
Application of the PDCA Cycle for Managing Hyperglycemia in Critically Ill Patients
To the best of our knowledge, this is the first report on using the PDCA cycle to manage and control glucose levels in critically ill patients (Diabetes Therapy)
Mounjaro
The European Medicines Agency therefore decided that Mounjaro’s benefits are greater than its risks and it can be authorised for use in the EU
Prognostic value of creatinine-to-cystatin c ratio in patients with type 2 diabetes mellitus: a cohort study
Low muscle mass assessed by Scr/Scys was associated with increased risk of long-term all-cause mortality in diabetic patients (Diabetology & Metabolic Syndrome)
A personalized multi-interventional approach focusing on customized nutrition, progressive fitness, and lifestyle modification resulted in the reduction of HbA1c, fasting blood sugar and weight in type 2 diabetes
The findings indicate that a comprehensive and multi-interventional diabetes care program involving personalized nutrition, fitness, and lifestyle modification such as SDRP, help in significant and sustained improvements in HbA1c level, glycaemic control, and weight loss in adults with type 2 diabetes (BMC Endocrine Disorders)
Screening all older adults aged 40-70 years would find undiagnosed type 2 diabetes cases at least two years earlier
Our study provides the first population-based estimate of the impact of HbA1c-based screening on reducing the time to diabetes diagnosis. In UK Biobank (Diabetologia )
The Platelet-to-Lymphocyte Ratio Predicts Diabetic Retinopathy in Type 2 Diabetes Mellitus
Our findings suggest that PLR may be an independent risk factor for evaluating DR in type 2 diabetes patients (Diabetes, Metabolic Syndrome and Obesity)
Development of a Measure to Assess Attitudes Towards Nasal versus Autoinjector Glucagon Delivery Devices for Treatment of Severe Hypoglycemia
This study supports the validity and reliability of the GDAQ, which successfully conceptualizes attitudes towards devices for administering glucagon among different respondent groups. Use of the GDAQ can help guide the development and testing of new glucagon drug/device combination (Diabetes, Metabolic Syndrome and Obesity)
Sleep and Circadian Rhythm Disturbances in Diabetes: A Narrative Review
We concluded that sleep and circadian rhythm disturbances are closely linked with diabetes. More attention to sleep in regular diabetes care is warranted, while further research is needed on treatment of sleep and circadian rhythm disturbances in the prevention of diabetes and its suboptimal outcomes (Diabetes, Metabolic Syndrome and Obesity)
Attendance at pre-pregnancy care clinics for women with type 1 diabetes: a scoping review
This review highlights the ongoing problem of poor-attendance at PPC and identifies key barriers to be addressed when developing and implementing PPC programs for women with type 1 diabetes (Diabetic Medicine)
Protection against stroke with glucagon-like peptide-1 receptor agonists: a comprehensive review of potential mechanisms
The available evidence remains however insufficient to confirm whether other effects of GLP-1RAs such as direct cardioprotective actions (i.e., effects on atrial electrical remodeling, increased left ventricular ejection fraction, increased myocardial salvage, effects on cardiac oxidative metabolism) and effects on the microvascular function may mechanistically contribute to GLP-1RA-mediated protection against stroke (Cardiovascular Diabetology)
Optimal Frequency of Urinary Albumin Screening in Type 1 Diabetes
A personalized alternative to annual screening in type 1 diabetes can substantially reduce both the time with undetected kidney disease and the frequency of urine testing (Diabetes Care)
Safety and Efficacy of an Oral Insulin (Capsulin) in Patients with Early-Stage Type 2 Diabetes: A Dose-Ranging Phase IIb Study
Capsulin oral insulin administered twice per day at a dose of 150iu per capsule is safe, with no confirmed treatment-linked hypoglycaemic events, and results in significant decreases from baseline in HbA1c, Fasting Plasma Glucose and triglycerides (Diabetes, Obesity and Metabolism)
Pathophysiology of type 2 diabetes in sub-Saharan Africans
In this review, we summarise the existing knowledge base and data from the only non-pharmacological intervention that explores the pathophysiology of type 2 diabetes in SSA (Diabetologia)
Management of hyperglycaemia in type 2 diabetes, 2022
A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) (Diabetologia)
Impact of sodium-glucose cotransporter-2 inhibitors on heart failure and mortality in patients with cancer
The use of SGLT2i was associated with a lower rate of incident HF and prolonged overall survival in patients with cancer with diabetes mellitus (Heart Journal)
Empagliflozin in Patients with Chronic Kidney Disease
Among a wide range of patients with chronic kidney disease who were at risk for disease progression, empagliflozin therapy led to a lower risk of progression of kidney disease or death from cardiovascular causes than placebo (NEJM)
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