Our multivariable prediction model identified patients at increased risk of admission in the 12 months following assessment (Pediatric Diabetes)
Diabetes News
Glycosmedia is dedicated to bringing free, non-promotional, editorially independent news to a global audience about developments in diabetes, and is primarily aimed at health professionals.
Effect of Intensive Glycemic and Blood Pressure Control on QT Prolongation in Diabetes: The ACCORD Trial
The increased mortality observed in the intensive glycemic control arm in the ACCORD trial is not likely to be explained by QT prolongation leading to lethal ventricular arrhythmias (Diabetes)
Sodium–Glucose Cotransporter-2 Inhibitors and the Risk for Diabetic Ketoacidosis
SGLT-2 inhibitors were associated with an almost 3-fold increased risk for DKA, with molecule-specific analyses suggesting a class effect (Annals of Internal Medicine)
Limited Evidence for the Health Effects and Safety of Intermittent Fasting Among Patients With Type 2 Diabetes
The value of intermittent fasting compared with other dietary regimens is unclear given the potentially higher risk of adverse events during intermittent fasting, whereas the best, but limited, evidence suggests that the efficacy of intermittent fasting was only noninferior to caloric restriction for hemoglobin A1c improvement and weight loss (JAMA)
Persons with type 2 diabetes and high insulin persistence were associated with a lower risk of mortality
This study showed that patients with ≥90% insulin persistence were associated with lower risks of all‐cause mortality than did patients with <90% insulin persistence (Journal of Diabetes Investigation)
Progression of Diabetic Retinopathy and Declining Renal Function in Patients with Type 2 Diabetes
Declining renal function was independently associated with DR progression in patients with NPDR, suggesting that investigation of DR status should be recommended for patients with declining renal function (Journal of Diabetes Research)
Impact of a Weekly Glucagon-Like Peptide 1 Receptor Agonist, Albiglutide, on Glycemic Control and on Reducing Prandial Insulin Use in Type 2 Diabetes Inadequately Controlled on Multiple Insulin Therapy
A once-weekly GLP-1RA was able to substitute for prandial insulin in 54% of people, substantially reducing the number of prandial insulin injections; glycemic control improved, with the added benefits of weight loss and less hypoglycemia in the GLP-1RA arm. Replacing prandial insulin with a weekly GLP-1RA can simplify basal plus prandial insulin treatments and achieve better outcomes in type 2 diabetes (Diabetes Care)
Insulin glargine/lixisenatide fixed‐ratio combination (iGlarLixi ) compared to premix or addition of meal‐time insulin to basal insulin in people with type 2 diabetes
iGlarLixi demonstrated similar or improved efficacy and safety versus other intensification choices from BI included in this study, providing a clinically relevant treatment option in people with T2D not well controlled on BI (Diabetes, Obesity and Metabolism)
Organisation of primary diabetes care in people with type 2 diabetes in relation to all-cause mortality: a nationwide register-based cohort study
This nationwide register-based cohort study suggests that the number of WTE GPs devoted to diabetes care have an impact on the risk of early death in people with T2DM (Diabetes Research and Clinical Practice)
Pain in Patients With Type 2 Diabetes-Related Polyneuropathy Is Associated With Vascular Events and Mortality
Our study found a significant association between pain in DPN and an increased risk of vascular events and mortality (Journal of Clinical Endocrinology & Metabolism)
A disease state approach to the pharmacological management of Type 2 diabetes in primary care
A position statement by Primary Care Diabetes Europe
Influenza Vaccination Is Associated With Reduced Cardiovascular Mortality in Adults With Diabetes: A Nationwide Cohort Study
In patients with diabetes, influenza vaccination was associated with a reduced risk of all-cause death, cardiovascular death, and death from AMI or stroke. Influenza vaccination may improve outcome in patients with diabetes (Diabetes Care)
Bile Acids: Key Regulators and Novel Treatment Targets for Type 2 Diabetes
we provide an overview of the mechanisms underlying the role of bile acids in glucose and lipid metabolism, as well as the occurrence and development of T2DM. Bile acid-targeted therapy may represent a valid approach for T2DM treatment (Journal of Diabetes Research)
Association Between HbA1c Levels and Cardiovascular Outcomes in Patients With Type 2 Diabetes and Cardiovascular Disease
HbA1c exhibits a U‐shaped association with cardiovascular outcomes in patients with T2D and atherosclerotic vascular disease, with nadir around 7% (European Journal of Heart Failure)
Switching to Degludec is Associated with Reduced Hypoglycaemia, Irrespective of Definition Used or Patient Characteristics: Secondary Analysis of the ReFLeCT Prospective, Observational Study
These results demonstrate that switching to degludec from other basal insulins was associated with reduced rates of hypoglycaemia, irrespective of the definition used or baseline patient characteristics (Diabetes Therapy)
Coronavirus infection (SARS-CoV-2) in obesity and diabetes comorbidities: is heat shock response determinant for the disease complications?
A new hypothesis that aims to explain the increased severity of SARS-CoV-2 infection in people with metabolic diseases, and the possible benefits of HSR-inducing therapies to improve the inflammatory profile in these patients (Diabetology & Metabolic Syndrome)
Effect of Flash Glucose Monitoring on Glycemic Control, Hypoglycemia, Diabetes-Related Distress, and Resource Utilization in the Association of British Clinical Diabetologists (ABCD) Nationwide Audit
We show that the use of FSL was associated with significantly improved glycemic control and hypoglycemia awareness and a reduction in hospital admissions (Diabetes Care)
ABCD COVID-19 & Diabetes: UK national audit
This audit aims to explore the clinical features and presentation of people admitted with diabetes and COVID-19. Through capturing detailed real-world data on the clinical presentation, co-morbidities, therapies and outcomes we hope to gain better insight into the impact of COVID-19 on those living with diabetes (ABCD)
The Role of Recombinant Proteins and Growth Factors in the Management of Diabetic Foot Ulcers: A Systematic Review of Randomized Controlled Trials
Overall, there is a greater agreement on the effectiveness of EGF to enhance the healing of diabetic ulcers. Nevertheless, extant evidence is lacking for other agents since few trials have been conducted for most of the growth factors and available studies are heterogeneous in their methodologies (Journal of Diabetes Research)
Efficacy of Modern Diabetes Treatments DPP-4i, SGLT-2i, and GLP-1RA in White and Asian Patients With Diabetes
The glucose-lowering efficacy of SGLT-2i, and to a lesser extent DPP-4i, was greater in studies of predominantly Asian ethnicity compared with studies of predominantly white ethnicity. There was no difference seen by ethnicity for GLP-1RA (Diabetes Care)
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