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Diabetes News

Category: Genetics


Type 2 diabetes classification: a data-driven cluster study of the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) cohort

April 18th 2022

Different HOMA2-based approaches did not classify patients with T2D in a consistent manner. The T2D classes characterized by high insulin resistance/hyperinsulinemia appeared most distinct (BMJ Open, Diabetes Research & Care)

Categories: Genetics, Monitoring, News
Tags: hyperinsulinemia, Insulin resistance, Type 2 Diabetes

Categories: Genetics, Monitoring
Tags: hyperinsulinemia, Insulin resistance, Type 2 Diabetes

Associations between deduced first islet specific autoantibody with sex, age at diagnosis and genetic risk factors in young children with type 1 diabetes

April 11th 2022

Strong differences in sex and age distributions as well as in genetic associations could be observed between GADA- and IAA-initiated autoimmunity (Pediatric Diabetes)

Categories: Genetics, News, Paediatrics, Pathology
Tags: autoantibody, Islet, Type 1 Diabetes

Categories: Genetics, Paediatrics, Pathology
Tags: autoantibody, Islet, Type 1 Diabetes

Clinical cardiovascular phenotypes and the pattern of future events in patients with type 2 diabetes

April 10th 2022

In T2D, a patient’s cardiovascular phenotype can help predict the pattern of future cardiovascular events (Clinical Research in Cardiology)

Categories: Cardiovascular, Genetics, News
Tags: GLP1 RA, SGLT2 inhibitors, Type 2 Diabetes

Categories: Cardiovascular, Genetics
Tags: GLP1 RA, SGLT2 inhibitors, Type 2 Diabetes

Prediabetes blunts DPP4 genetic control of postprandial glycaemia and insulin secretion

February 23rd 2022

These results showed the DPP4 gene as a strong determinant of post-OGTT levels via glucose-sensing mechanisms that are abrogated in prediabetes (Diabetologia)

Categories: Genetics, News
Tags: DPP4

Categories: Genetics
Tags: DPP4

Epigenome-wide association study of incident type 2 diabetes: a meta-analysis of five prospective European cohorts

February 17th 2022

By combining results from five European cohorts, and thus significantly increasing study sample size, we identified 76 CpG sites associated with incident type 2 diabetes (Diabetologia)

Categories: Genetics, News
Tags: Type 2 Diabetes

Categories: Genetics
Tags: Type 2 Diabetes

Improvements in Awareness and Testing Have Led to a Threefold Increase Over 10 Years in the Identification of Monogenic Diabetes in the U.K.

January 25th 2022

Since 2009, referral rates and case diagnosis have increased threefold. This is likely to be the consequence of tNGS, GDN education, and use of the MODY calculator (Diabetes Care)

Categories: Genetics, News, Screening
Tags: sequencing

Categories: Genetics, Screening
Tags: sequencing

Recessive Genome-wide Meta-analysis Illuminates Genetic Architecture of Type 2 Diabetes

December 12th 2021

These results demonstrate that recessive models, when compared to GWAS using the additive approach, can identify novel loci, including large-effect variants with pathophysiological consequences relevant to type 2 diabetes (Diabetes)

Categories: Genetics, News
Tags: Type 2 Diabetes

Categories: Genetics
Tags: Type 2 Diabetes

Adiponectin gene polymorphisms and risk of type 2 diabetes: an updated evidence for meta-analysis

November 18th 2021

Collectively, our findings demonstrated a positive association between ADIPOQ + 276 G > T polymorphism with increased risk of T2D in male individuals with European ethnicity (Diabetology & Metabolic Syndrome)

Categories: Biochemistry, Genetics, News, Pathology
Tags: adiponectin, Type 2 Diabetes

Categories: Biochemistry, Genetics, Pathology
Tags: adiponectin, Type 2 Diabetes

Diabetes: Concepts of β-Cell Organ Dysfunction and Failure Would Lead to Earlier Diagnoses and Prevention

October 28th 2021

There is a potential to identify both T2D and T1D at stages well before the onset of currently recognized clinical disease (Diabetes)

Categories: Genetics, News, Screening
Tags: Type 1 Diabetes, Type 2 Diabetes, β-cell

Categories: Genetics, Screening
Tags: Type 1 Diabetes, Type 2 Diabetes, β-cell

What Is in the Field for Genetics and Epigenetics of Diabetic Neuropathy: The Role of MicroRNAs

October 6th 2021

In this scenario, the genetics of microRNAs is at a very preliminary stage. Notwithstanding, the study of genetics and epigenetics of miRNAs may well contribute to the identification of exploratory biomarkers of risk and pathogenetic mechanisms of diabetic neuropathy and to a comprehensive definition of susceptibility to specific pathogenetic mechanisms to favor a tailored mechanism-based treatment or prevention (Journal of Diabetes Research)

Categories: Genetics, Neuropathy, News
Tags: epigenetics, microRNA

Categories: Genetics, Neuropathy
Tags: epigenetics, microRNA

Incorporation of a genetics-based information module into standardized diabetes patient education

May 14th 2021

The educational module increased understanding of diabetes and increased motivation to adopt healthy behaviors (Primary Care Diabetes)

Categories: Education, Genetics, News
Tags: motivation

Categories: Education, Genetics
Tags: motivation

Association of genetic variants for plasma LRG1 with rapid decline in kidney function in patients with type 2 diabetes

April 27th 2021

We demonstrate that genetically influenced plasma LRG1 increases the risk of RDKF in T2D patients suggesting plasma LRG1 as a potential treatment target. However, further studies are warranted to elucidate underlying pathways to provide insight into DKD prevention (Journal of Clinical Endocrinology & Metabolism)

Categories: Genetics, Nephropathy, News
Tags: Type 2 Diabetes

Categories: Genetics, Nephropathy
Tags: Type 2 Diabetes

Increased frequency of β cells with abnormal NKX6.1 expression in type 2 diabetes but not in subjects with higher risk for type 2 diabetes

March 14th 2021

Our results suggested that NKX6.1 expression in β cells was changed in type 2 diabetic subjects, evidenced by significantly increased NKX6.1Nuc-Ins+ and NKX6.1cytIns− cells. This abnormality did not occur more frequently in subjects with a higher risk for T2DM, suggesting that β cell dedifferentiation might be secondary to the pathological changes in T2DM (BMC Endocrine Disorders)

Categories: Genetics, News

Categories: Genetics

Two decades since the fetal insulin hypothesis: what have we learned from genetics?

March 8th 2021

In summary, there is now ample evidence to support the idea that variants of certain genes which result in impaired pancreatic beta cell function and reduced insulin secretion contribute to both lower birthweight and higher type 2 diabetes risk in later life when inherited by the fetus (Diabetologia)

Categories: Genetics, Gestational, News
Tags: fetal, insulin

Categories: Genetics, Gestational
Tags: fetal, insulin

Genomic risk score provides predictive performance for type 2 diabetes in the UK biobank

January 4th 2021

The metaGRS significantly improves T2D prediction ability (Acta Diabetologica)

Categories: Genetics, News
Tags: Type 2 Diabetes

Categories: Genetics
Tags: Type 2 Diabetes

Glucose metabolism-related gene polymorphisms as the risk predictors of type 2 diabetes

November 5th 2020

In this review, we have summarized the results reported globally and found that the genetic variants of GCK and OCT3 genes is a risk factor for T2DM while G6PC2 and GCKR genes are controversial in different ethnic groups (Diabetes, Metabolic Syndrome)

Categories: Genetics, News
Tags: polymorphisms, Type 2 Diabetes

Categories: Genetics
Tags: polymorphisms, Type 2 Diabetes

Integrating Genetics and the Plasma Proteome to Predict the Risk of Type 2 Diabetes

October 8th 2020

Studies of the human plasma proteome have started to elucidate its potential for T2D prediction and biomarker discovery (Current Diabetes Reports)

Categories: Genetics, News
Tags: Type 2 Diabetes

Categories: Genetics
Tags: Type 2 Diabetes

Next steps in the identification of gene targets for type 1 diabetes

September 30th 2020

The purpose of this review is to provide a view of the future of genomics and other omics approaches in defining the genetic contribution to all stages of risk of type 1 diabetes and the functional impact and clinical implementations of the associated variants (Diabetologia)

Categories: Genetics, News
Tags: Type 1 Diabetes

Categories: Genetics
Tags: Type 1 Diabetes

Effect of sidt2 Gene on Cell Insulin Resistance and Its Molecular Mechanism

September 14th 2020

sidt2 knockout can reduce glucose uptake in peripheral tissue under insulin stimulation, which may lead to peripheral tissue insulin resistance by affecting the IRS-1 signal pathway (Journal of Diabetes Research)

Categories: Genetics, News
Tags: Insulin resistance

Categories: Genetics
Tags: Insulin resistance

What Next After Metformin in Type 2 Diabetes? Selecting the Right Drug for the Right Patient

May 19th 2020

This study identified patients’ phenotypic characteristics that may have the potential to influence individual treatment response. Accounting for these characteristics in clinical treatment decisions may facilitate individualised prescribing by being able to select the right drug for the right patient (Diabetes Therapy)

Categories: Genetics, News
Tags: metformin, phenotypic, Type 2 Diabetes

Categories: Genetics
Tags: metformin, phenotypic, Type 2 Diabetes
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