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Diabetes News

Category: Gestational


Association between maternal triglycerides and disturbed glucose metabolism in pregnancy

January 3rd 2021

Hypertriglyceridemia at the start of pregnancy is closely related to impaired insulin action and β-cell function. Women with hypertriglyceridemia have higher mean glucose levels in early- and mid-gestation. Pregnant women with elevated triglycerides in early pregnancy are at increased risk of developing gestational diabetes (Acta Diabetologica)

Categories: Gestational, News
Tags: hypertriglyceridemia

Categories: Gestational
Tags: hypertriglyceridemia

Endocrinology in the time of COVID-19: Diagnosis and management of gestational diabetes mellitus

December 1st 2020

We suggest pragmatic options for screening of GDM in a pandemic setting based on blood tests, and risk calculators applied to underlying risk factors (European Journal of Endocrinology)

Categories: Gestational, News
Tags: COVID-19

Categories: Gestational
Tags: COVID-19

Type 1 and type 2 diabetes after gestational diabetes: a 23 year cohort study

November 20th 2020

All women with GDM should be intensively monitored for a decade, after which the risk for type 1 diabetes is minimal. However, the incidence of type 2 diabetes remains linear, and therefore individualised lifelong follow-up is recommended (Diabetologia)

Categories: Gestational, Monitoring, News
Tags: Type 1 Diabetes, Type 2 Diabetes

Categories: Gestational, Monitoring
Tags: Type 1 Diabetes, Type 2 Diabetes

Metformin in women with type 2 diabetes in pregnancy (MiTy): a multicentre, international, randomised, placebo-controlled trial

October 6th 2020

We found several maternal glycaemic and neonatal adiposity benefits in the metformin group. Along with reduced maternal weight gain and insulin dosage and improved glycaemic control, the lower adiposity and infant size measurements resulted in fewer large infants but a higher proportion of small-for-gestational-age infants (The Lancet Diabetes & Endocrinology)

Categories: Gestational, News
Tags: metformin, Type 2 Diabetes

Categories: Gestational
Tags: metformin, Type 2 Diabetes

Metformin in women with type 2 diabetes in pregnancy (MiTy): a multicentre, international, randomised, placebo-controlled trial

September 18th 2020

We found several maternal glycaemic and neonatal adiposity benefits in the metformin group. Along with reduced maternal weight gain and insulin dosage and improved glycaemic control, the lower adiposity and infant size measurements resulted in fewer large infants but a higher proportion of small-for-gestational-age infants (The Lancet Diabetes & Endocrinology)

Categories: Gestational, News
Tags: metformin, Type 2 Diabetes

Categories: Gestational
Tags: metformin, Type 2 Diabetes

Metformin in women with type 2 diabetes in pregnancy (MiTy): a multicentre, international, randomised, placebo-controlled trial

September 17th 2020

We found several maternal glycaemic and neonatal adiposity benefits in the metformin group. Along with reduced maternal weight gain and insulin dosage and improved glycaemic control, the lower adiposity and infant size measurements resulted in fewer large infants but a higher proportion of small-for-gestational-age infants (The Lancet Diabetes & Endocrinology)

Categories: Gestational, News
Tags: metformin, Type 2 Diabetes

Categories: Gestational
Tags: metformin, Type 2 Diabetes

DTN-UK launch Best Practice Guide for Diabetes Technology in Pregnancy

June 30th 2020

Written by the leading experts in pregnancy in type 1 diabetes in the UK, the guide has useful tips, guidance and details about the use of insulin pumps, flash glucose monitoring and continuous glucose monitoring in pregnancy (ABCD)

Categories: Gestational, News
Tags: ABCD

Categories: Gestational
Tags: ABCD

Longitudinal changes in glucose metabolism in women with gestational diabetes, from late pregnancy to the postpartum period

December 9th 2019

In women with GDM, delivery was associated with improvement in both insulin sensitivity and insulin production within the first few days. Improvement in insulin production persisted for 6–12 weeks, but insulin sensitivity deteriorated slightly (Diabtologia)

Categories: Gestational, News
Tags: insulin sensitivity

Categories: Gestational
Tags: insulin sensitivity

The Utility of Lower Glycemic Targets for Treating Gestational Diabetes: A Retrospective Study

December 5th 2019

Lower glycemic targets did not produce large reductions in fetal overgrowth, but they were associated with a higher rate of inductions. As there were no observed differences in maternal or neonatal outcomes otherwise, aiming for lower glycemic targets in GDM is likely not cost-effective (Journal of Diabetes Research)

Categories: Gestational, News
Tags: targets

Categories: Gestational
Tags: targets

The Gut Microbiota in Women Suffering from Gestational Diabetes Mellitus with the Failure of Glycemic Control by Lifestyle Modification

October 23rd 2019

Blautia, Faecalibacterium, and Eubacterium_hallii_group had important characteristic changes in the gut microbiota of women with GDM2. The relative abundance of Faecalibacterium, Blautia, and Eubacterium_hallii_group can discriminate GDM2 from GDM. Gut bacteria may participate in the pathological development of GDM2 through the PPAR signaling pathway, which should be conducted for further study in the future (Journal of Diabetes Research)

Categories: Gestational, News
Tags: gut microbiota

Categories: Gestational
Tags: gut microbiota

Screening for monogenic diabetes in primary care

June 26th 2019

The benefits and implications of life altering treatment such as termination of insulin administration are significant but little can be done without appropriate identification and referral (Primary Care Diabetes)

Categories: Gestational, News
Tags: monogenic

Categories: Gestational
Tags: monogenic

Modelling potential cost savings from use of real‐time continuous glucose monitoring in pregnant women with Type 1 diabetes

June 4th 2019

Routine use of RT‐CGM by pregnant women with type 1 diabetes, would result in substantial cost savings, mainly through reductions in NICU admissions and shorter duration of NICU care (Diabetes Medicine)

Categories: Gestational, News
Tags: CGM, RT‐CGM, Type 1 Diabetes

Categories: Gestational
Tags: CGM, RT‐CGM, Type 1 Diabetes

Impaired awareness of hypoglycemia: a new risk factor for adverse pregnancy outcomes in type 1 diabetes

May 8th 2019

Impaired awareness of hypoglycemia: a new risk factor for adverse pregnancy outcomes in type 1 diabetes (Diabetes Research and Clinical Practice)

Categories: Gestational, News
Tags: hypoglycemia, Type 1 Diabetes

Categories: Gestational
Tags: hypoglycemia, Type 1 Diabetes

Testing for type 1 diabetes autoantibodies in gestational diabetes mellitus (GDM): is it clinically useful?

May 4th 2019

From several epidemiological studies it appears that diabetes-related autoimmunity is not a main factor in the aetiology of GDM, accounting for less than 10% of all cases (BMC Endocrine Disorders)

Categories: Gestational, News
Tags: autoantibodies, Type 1 Diabetes

Categories: Gestational
Tags: autoantibodies, Type 1 Diabetes

Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study (HAPO FUS): Maternal Gestational Diabetes Mellitus and Childhood Glucose Metabolism

February 21st 2019

Offspring exposed to untreated GDM in utero are insulin resistant with limited β-cell compensation compared with offspring of mothers without GDM. GDM is significantly and independently associated with childhood IGT  (Diabetes Care)

Categories: Gestational, News
Tags: hyperglycemia

Categories: Gestational
Tags: hyperglycemia

Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study (HAPO FUS): Maternal Glycemia and Childhood Glucose Metabolism

February 21st 2019

Across the maternal glucose spectrum, exposure to higher levels in utero is significantly associated with childhood glucose and insulin resistance independent of maternal and childhood BMI and family history of diabetes (Diabetes Care)

Categories: Gestational, News
Tags: hyperglycemia

Categories: Gestational
Tags: hyperglycemia

The association between Gestational Diabetes and Postpartum Depression: A Systematic Review and Meta-analysis

February 6th 2019

The association between Gestational Diabetes and Postpartum Depression: A Systematic Review and Meta-analysis (Diabetes Research and Clinical Practice)

Categories: Gestational, News
Tags: depression, postpartum

Categories: Gestational
Tags: depression, postpartum

Experiences of women, hospital clinicians and general practitioners with gestational diabetes mellitus postnatal follow-up: A mixed methods approach

December 21st 2018

This research informs seven practical recommendations to help promote completion of recommended postnatal GDM follow-up (Diabetes Research and Clinical Practice)

Categories: Gestational, News
Tags: follow up

Categories: Gestational
Tags: follow up

A systematic review on costs and cost-effectiveness of screening and prevention of type 2 diabetes in women with prior gestational diabetes: exploring uncharted territory

December 7th 2018

An oral glucose tolerance test per three years leads to the lowest cost per case detected, and prevention is potentially cost-effective or cost-saving. More health economic evaluations are needed that compare all relevant alternatives, including ‘doing nothing’ (Diabetes Research and Clinical Practice)

Categories: Gestational, News
Tags: OGTT, Type 2 Diabetes

Categories: Gestational
Tags: OGTT, Type 2 Diabetes

Effect of metformin in addition to dietary and lifestyle advice for pregnant women who are overweight or obese: the GRoW randomised, double-blind, placebo-controlled trial

December 5th 2018

For pregnant women who are overweight or obese, metformin given in addition to dietary and lifestyle advice initiated at 10–20 weeks’ gestation does not improve pregnancy and birth outcomes (The Lancet Diabetes & Endocrinology)

Categories: Gestational, News
Tags: metformin

Categories: Gestational
Tags: metformin
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