The magnitude of cancer risk reduction and prolonged cancer onset times produced by metformin in patients with type 2 diabetes depended on the dose of metformin, regardless of whether metformin was used alone or combined with other antidiabetic drugs (Pharmacotherapy)
Diabetes News
Category: Medication
Efficacy & safety of canagliflozin versus glimepiride – T2D
Canagliflozin provides greater HbA1c reduction than does glimepiride, and is well tolerated in patients with type 2 diabetes receiving metformin. These findings support the use of canagliflozin as a viable treatment option for patients who do not achieve sufficient glycaemic control with Metformin therapy (The Lancet)
Efficacy and safety of canagliflozin versus glimepiride T2D
Canagliflozin provides greater HbA1c reduction than does glimepiride, and is well tolerated in patients with type 2 diabetes receiving metformin. These findings support the use of canagliflozin as a viable treatment option for patients who do not achieve sufficient glycaemic control with metformin therapy (The Lancet)
Taspoglutide improves postprandial insulin secretion in metformin T2D
Taspoglutide QW significantly improved pancreatic function in patients with T2D treated with metformin (Metabolism – Clinical and Experimental)
Efficacy and Safety of Adding Pioglitazone or Sitagliptin in T2D
Pioglitazone and sitagliptin achieved similar improvements in overall glycemic control in patients with type 2 diabetes inadequately controlled with metformin and a sulfonylurea. However there were some differences in terms of FPG, high sensitive C-reactive protein, lipids, body weight change and adverse events (Endocrine Practice)
Efficacy and safety of dipeptidyl peptidase-4 inhibitors and
DPP-4 inhibitors, which were safe and effective in controlling the blood glucose, may possibly decrease the risk of CV events in patients with T2DM. It could be a credible alternative for T2DM patients who, for some reason, cannot use metformin, or are in high risk of CV exposure. High-quality, large sample and long-term follow-up clinical trails are needed to confirm the long-term conclusions (Diabetes, Obesity and Metabolism)
Insulin-deficient bone microarchitecture: Preventive effects – metformin
Partially insulin-deficient diabetes induces deleterious effects on long-bone micro-architecture that are associated with a decrease in BMPC osteogenic potential, which could be mediated by a decrease in their Runx-2/PPAR? ratio and up-regulation of RAGE. These diabetes-induced alterations can be totally or partially prevented by oral administration of metformin (Diabetes Research and Clinical Practice)
Dapagliflozin in combination therapy for treating T2D
NICE technology appraisal guidance 288
The kidney as a new target for SGLT2 inhibitors
A sufficient number of clinical trials have been conducted on sufficiently chemically diverse SGLT2 inhibitors to reasonably conclude that they have efficacy (HbA1c reductions of 0·4–1%), and thus far, the majority of adverse effects have been mild and transitory or treatable, with the caveat of possible association with increased risk of breast cancer in women and bladder cancer in men (Journal of Clinical Pharmacy and Therapeutics)
Readjudication of the Rosiglitazone RECORD Trial
Joint Meeting of the Endocrinologic and Metabolic Drugs Advisory Committee and the Drug Safety and Risk Management Advisory Committee (Food and Drug Administration)
Diabetes (type 2) – dapagliflozin: final appraisal determination
After considering the feedback from consultation, the Appraisal Committee has prepared a Final Appraisal Determination (FAD) on Dapagliflozin in combination therapy for treating type 2 diabetes [ID427] and submitted it to the Institute (NICE)
Insulin degludec improves glycaemic control – lower nocturnal hypo
Long-term basal therapy using insulin degludec in Type 1 diabetes required lower doses and was associated with a 25% lower risk for nocturnal hypoglycaemia than insulin glargine (Diabetic Medicine)
Metformin Associated with Higher Remission Rate with Thyroid Cancer
Tumor size is smaller in patients treated with metformin suggesting inhibition of tumor growth by the drug (Journal of Clinical Endocrinology & Metabolism)
Risk of incident diabetes among patients treated with statins
Compared with pravastatin, treatment with higher potency statins, especially atorvastatin and simvastatin, might be associated with an increased risk of new onset diabetes (BMJ)
Key vildagliptin data in The Lancet
Show for the first time individualized HbA1c treatment goals can be reached in elderly type 2 diabetes patients with no major tolerability issues (Novartis)
NICE says yes to ranibizumab for common eye condition
The National Institute for Health and Care Excellence (NICE) has issued final guidance recommending ranibizumab (Lucentis, Novartis) as a treatment for sight problems caused by macular oedema (NICE)
DPP-4 inhibition & vascular repair – mobilization endogenous stem cells
DPP-4 inhibitors and the study of ancillary effects is gaining an increasing interest for the possible cardiovascular benefit of these drugs beyond glucose control. As DPP-4 inhibitors show favorable safety profiles and do not cause hypoglycemia, they are attractive drugs also for non-diabetic patients and may become part of a vascular regenerative pharmacotherapy (Atherosclerosis)
DPP-4 inhibitors: Multi-target drugs, not only anti-diabetes
Recently, some therapeutic effects of DPP-4 inhibitors, such as immune regulation, cardiovascular protection and anti-inflammatory effect have been gradually observed. This article provides a systematic and comprehensive review of current researches on the newly-found effect and mechanism of DPP-4 inhibitors in therapy (Journal of Diabetes)
Liraglutide suppresses postprandial triglyceride & apolipoprotein B48
Liraglutide treatment in patients with type 2 diabetes significantly reduced postprandial excursions of triglyceride and apolipoprotein B48 after a fat-rich meal, independently of gastric emptying. Results indicate liraglutide’s potential to reduce cardiovascular disease risk via improvement of postprandial lipaemia (Diabetes, Obesity and Metabolism)
Audit of clinical practice in use of incretin mimetic agents T2D
It was concluded that good metabolic control can be achieved if these agents are used judiciously. The DPP-4 inhibitors improve HbA1c but are weight neutral, while the GLP-1R agonists cause both weight loss and improvements in HbA1c. The addition of insulin under specialist supervision can be beneficial (Practical Diabetes)
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