Diabetes News

Elevation of plasma advanced oxidized protein products was an independent risk factor for endothelial dysfunction, and therefore, might be an early marker of vasculopathy in individuals with early stage of diabetes (Journal of Diabetes)

High E2 level is an independent predictor of incident dementia, particularly in postmenopausal women with diabetes (Neurology)

Circadian variations in glucose homeostasis were assessed on relevant parameters, and a significant improvement was achieved by including a circadian rhythm on the endogenous glucose production in the model. The extended model is a useful tool for clinical trial simulation and for elucidating the effect profile of new insulin products (Journal of Clinical Pharmacology)

This new index correlates well with the reference oral minimal model estimate of insulin sensitivity. The knowledge of patient-specific insulin sensitivity and its diurnal variation can help in optimizing insulin therapy in type 1 diabetes and could also inform the next generation closed-loop control systems (Diabetes Care)

This pilot study has shown that in children and adolescents with established type 1 diabetes, abnormal microvasculature can be detected by nailfold capillaroscopy, laser Doppler flowmetry, retinal vessel analysis and 24-hr ambulatory blood pressure monitoring (BMC Endocrine Disorders)

For a given degree of glycemia, HbA1c levels vary among different ethnic groups. Ethnicity needs to be taken into account when using HbA1c to assess glycemic control or to set glycemic targets. Estimated AG is not a reliable marker for mean glycemia and therefore is of limited clinical value (Diabetes Care)

This paper presents the first psychosocial risk index for poor glycemic control in children newly diagnosed with type 1 diabetes. It is brief, easily administered, and provides a single score that translates directly into an estimate of risk that can help guide routine diabetes care (Pediatric Diabetes)

Physiological delay between blood glucose and interstitial fluid glucose should, therefore, not be an obstacle to sensor accuracy in overnight or fasting state closed loop systems of insulin delivery or open loop therapy assessment for type 1 diabetes (Diabetes)

Although the studies on the economic feasibility to use CGM as an educational tool must be carried out, we suggest that it can be used as a powerful motivational device to change patients’ lifestyle and to improve glycaemic control in type 2 diabetes (Diabetes/Metabolism Research and Reviews)

This ‘Diabetes MUR toolkit’ is designed to help improve the confidence of community pharmacy to provide high quality MURs for patients taking diabetes medicines (Devon Local Pharmaceutical Committee)

Severe hypoglycemia was common among patients with type 2 diabetes across all levels of glycemic control. Risk tended to be higher in patients with either near-normal glycemia or very poor glycemic control (Diabetes Care)

this T2D-IFG biomarker study has surveyed the broadest panel of non-targeted metabolites to date, revealing both novel and known associated metabolites and providing potential novel targets for clinical prediction and a deeper understanding of causal mechanisms (Diabetes)

Only inpatient blood glucose monitoring system among leading hospital brands to use individually foil-wrapped test strips, helping reduce risk of test strip cross-contamination (Abbott)

F-CPI was correlated only with unadjusted indexes of insulin secretion, whereas PP-CPI was correlated with such indexes as well as with those adjusted for insulin sensitivity. The better clinical utility of PP-CPI might be attributable to these physiological characteristics (Metabolism)

The present findings suggest that an HbA1c target of less than 6.5% or 48 mmol/mol might be too low for some patients and large reductions, or increases, in HbA1c levels should be approached cautiously. The findings also point to potential age-related differences in HbA1c levels and mortality rates with younger diabetes patients being at relatively greater risk of mortality associated with low HbA1c levels even though absolute risks are smaller at young ages (PLoS ONE)

The urinary C-peptide creatinine ratio is a practical non-invasive method to aid detection of absolute insulin deficiency, with a urinary C-peptide creatinine ratio > 0.2nmol/mmol being a reliable indicator of retained endogenous insulin secretion (Diabetic Medicine)

In subjects with impaired glucose regulation, HDL-C levels are associated with indices of beta-cell dysfunction; thus, more attention, it should be deserve to HDL-C concentrations in IFG/IGT patients due their potential conversion to DM2 (Acta Diabetologica)

Responding to SMBG test results and increased testing frequency were not associated with improved glycaemic control in the short-term. There is a lack of knowledge surrounding SMBG in non-insulin treated patients (Diabetes Research and Clinical Practice)

Lower proportion of type I fibers in metabolic syndrome muscle correlated with the severity of insulin resistance. Even though whole muscle content was normal, key elements of insulin action were consistently less in type I muscle fibers, suggesting their distribution was important in mediating insulin effects (Journal of Clinical Endocrinology & Metabolism)

Changes in immunity seen in individuals with high risk of developing T1D points to alterations/actions in the immune system already early in the pre-diabetic phase (Diabetes Research and Clinical Practice)