Chronic Kidney Disease (CKD) is a long-term irreversible deterioration in the function of the kidneys often found in patients who also have diabetes and high blood pressure (HQIP)
Diabetes News
Category: Nephropathy
Renal Protective Effect of DPP-4 Inhibitors in Type 2 Diabetes Mellitus Patients: A Cohort Study
Administration of DPP-4i reduces urine albumin excretion and mitigates reduction of eGFR in T2DM patients (Journal of Diabetes Research)
Combined Diabetes-Renal Multifactorial Intervention in Patients with Advanced Diabetic Nephropathy: Proof-of-Concept
The intervention delayed ESRD. Improved A1C and ACR plus not-yet-identified variables may have influenced better outcomes. Multifactorial-multidisciplinary care may serve as a CKD 3–4 treatment paradigm (Journal of Diabetes and Its Complications)
Urine Proteome Specific for Eye Damage Can Predict Kidney Damage in Patients With Type 2 Diabetes: A Case-Control and a 5.3-Year Prospective Cohort Study
Urine haptoglobin, which is specific for PDR, is a novel biomarker and complement to urine albumin for predicting kidney damage in patients with T2D (Diabetes Care)
Plasma Triglycerides and HDL-C Levels Predict the Development of Diabetic Kidney Disease in Subjects With Type 2 Diabetes: The AMD Annals Initiative
In a large population of outpatients with diabetes, low HDL-C and high TG levels were independent risk factors for the development of DKD over 4 years (Diabetes Care)
Clinical predictors differentiating non-diabetic renal diseases from diabetic nephropathy in a large population of type 2 diabetes patients
Shorter duration of diabetes (⩽5 years), absence of retinopathy, and presence of glomerular hematuria were independent indicators associated with NDRDs, indicating the need for renal biopsy (Diabetes Research and Clinical Practice)
Dipeptidyl peptidase −4 activity is associated with urine albumin excretion in type 1 diabetes
Our results indicate that serum DPP-4 activity is associated with albuminuria in type 1 diabetes. This arises the question whether the use of DPP-4 inhibitors might serve as an additional therapeutic strategy to prevent proteinuria in patients with DKD (Journal of Diabetes and Its Complications)
Clinical Manifestations of Kidney Disease Among US Adults With Diabetes, 1988-2014
Among US adults with diabetes from 1988 to 2014, the overall prevalence of diabetic kidney disease did not change significantly, whereas the prevalence of albuminuria declined and the prevalence of reduced eGFR increased (JAMA)
Interactions between kidney disease and diabetes: dangerous liaisons
Understanding the renal physiology and pathophysiology of DKD has become essential to all specialties treating diabetic patients (Diabetology & Metabolic Syndrome)
Individualized prediction of the effect of angiotensin receptor inhibition on renal and cardiovascular outcomes in patients with diabetic nephropathy
The combined effects of ARBs on ESRD and CVD and mortality in patients with diabetic nephropathy varies considerably between patients. A substantial proportion of patients remain at high risk for both outcomes despite ARB treatment (Diabetes, Obesity and Metabolism)
Urinary Biomarkers in the Assessment of Early Diabetic Nephropathy
The concomitant assessment of several urinary biomarkers in relationship with microalbuminuria could represent at present a method of diagnosing early DN. The great progress in discovering new biomarkers could lead to the development of an “ideal” urinary biomarker to detect early diabetic DN in the future (Journal of Diabetes Research)
Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes
In patients with type 2 diabetes at high cardiovascular risk, empagliflozin was associated with slower progression of kidney disease and lower rates of clinically relevant renal events than was placebo when added to standard care (NEJM)
A comparison between angiotensin converting enzyme inhibitors and angiotensin receptor blockers on end stage renal disease and major adverse cardiovascular events in diabetic patients
ACEi compared with ARB was associated with a lower incidence of ESRD, especially in those with CKD. Though ACEi and ARB had a similar risk of composite MACE outcome, ACEi had a slightly higher incidence of stroke than ARB, among the Asian diabetic patients (Cardiovascular Diabetology)
Association Between Plasma Uric Acid Levels and Cardiorenal Function in Adolescents With Type 1 Diabetes
Even within the physiological range, PUA levels were significantly lower in T1D adolescent patients compared with HC subjects. There was an inverse relationship between PUA and eGFR in T1D, likely reflecting an increase in clearance (Diabetes Care)
Immune Cells and Inflammation in Diabetic Nephropathy
In this review, the authors consider the metabolic profile of several relevant immune types and discuss their respective roles (Journal of Diabetes Research)
Non-Alcoholic Fatty Liver Disease Is a Risk Factor for the Development of Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus
NAFLD might be a risk factor for DN. Elevated liver fat content could be associated with higher DN burden (PLoS ONE)
Elevated baseline glomerular filtration rate (GFR) is independently associated with a more rapid decline in renal function of patients with type 1 diabetes
In patients with T1DM, higher baseline mGFR is associated with more rapid mGFR decline. Patients with high baseline mGFR who developed rapid mGFR decline had higher HbA1c measurements throughout the study. These findings are consistent with the concept that poor glycaemic control over time may be a determining factor for the rapid renal function decline observed in some hyperfiltering patients (Journal of Diabetes and Its Complications)
Early renin-angiotensin-system intervention is more beneficial than late intervention in delaying end-stage renal disease in patients with type 2 diabetes
RAS intervention early in the course of proteinuric DKD is more beneficial than late intervention in delaying ESRD (Diabetes, Obesity and Metabolism)
Helicobacter pylori infection associated with type 2 diabetic nephropathy in patients with dyspeptic symptoms
Diabetic nephropathy patients are more susceptible to H. pylori infection. Our data support an association between H. pylori infection and diabetic nephropathy (Diabetes Research and Clinical Practice)
Estimating Glomerular Filtration Rate: Performance of the CKD-EPI Equation over time in Patients with Type 2 Diabetes
The CKD-EPI formula underestimates mGFR and the rate of decline of mGFR in patients with type 2 diabetes with a mGFR greater than 60ml/min/1.73m2. The association between LDL cholesterol, triglycerides, HbA1c, diastolic blood pressure and the difference between mGFR and eGFR warrants further study (Journal of Diabetes and Its Complications)
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