Angiotensin-II may play an important role in the development of albuminuria, particularly in subjects with impaired glucose metabolism (Journal of Diabetes and Its Complications)
Diabetes News
Category: Nephropathy
Classification and Differential Diagnosis of Diabetic Nephropathy
Regardless of its limitations, the Tervaert classification represents a very meaningful step towards the establishment of a DN classification scheme with clinical utility. When the pathologist observes the pathological changes of DN, they still need to make a differential diagnosis with another nodular glomerulopathy and clarify whether it is a typical DN complicated with NDRD or not (Journal of Diabetes Research)
HbA1c variability in type 2 diabetes is associated with the occurrence of new-onset albuminuria within three years
HbA1c-CV improves 3-year prognostication of new-onset albuminuria. Together with mean HbA1c, baseline urine albumin and presence of hypertension, accurate 3-year new-onset albuminuria prognostication may be possible (Diabetes Research and Clinical Practice)
Assessment of urinary microparticles in normotensive patients with type 1 diabetes
Taken together, our data show that urinary podocyte MP levels are higher in patients with type 1 diabetes in advance of changes in other biomarkers (albuminuria, nephrin). Examination of podocyte MPs may serve as an early biomarker of glomerular injury in uncomplicated type 1 diabetes (Diabetologia)
National Chronic Kidney Disease Audit
Chronic Kidney Disease (CKD) is a long-term irreversible deterioration in the function of the kidneys often found in patients who also have diabetes and high blood pressure (HQIP)
Renal Protective Effect of DPP-4 Inhibitors in Type 2 Diabetes Mellitus Patients: A Cohort Study
Administration of DPP-4i reduces urine albumin excretion and mitigates reduction of eGFR in T2DM patients (Journal of Diabetes Research)
Combined Diabetes-Renal Multifactorial Intervention in Patients with Advanced Diabetic Nephropathy: Proof-of-Concept
The intervention delayed ESRD. Improved A1C and ACR plus not-yet-identified variables may have influenced better outcomes. Multifactorial-multidisciplinary care may serve as a CKD 3–4 treatment paradigm (Journal of Diabetes and Its Complications)
Urine Proteome Specific for Eye Damage Can Predict Kidney Damage in Patients With Type 2 Diabetes: A Case-Control and a 5.3-Year Prospective Cohort Study
Urine haptoglobin, which is specific for PDR, is a novel biomarker and complement to urine albumin for predicting kidney damage in patients with T2D (Diabetes Care)
Plasma Triglycerides and HDL-C Levels Predict the Development of Diabetic Kidney Disease in Subjects With Type 2 Diabetes: The AMD Annals Initiative
In a large population of outpatients with diabetes, low HDL-C and high TG levels were independent risk factors for the development of DKD over 4 years (Diabetes Care)
Clinical predictors differentiating non-diabetic renal diseases from diabetic nephropathy in a large population of type 2 diabetes patients
Shorter duration of diabetes (⩽5 years), absence of retinopathy, and presence of glomerular hematuria were independent indicators associated with NDRDs, indicating the need for renal biopsy (Diabetes Research and Clinical Practice)
Dipeptidyl peptidase −4 activity is associated with urine albumin excretion in type 1 diabetes
Our results indicate that serum DPP-4 activity is associated with albuminuria in type 1 diabetes. This arises the question whether the use of DPP-4 inhibitors might serve as an additional therapeutic strategy to prevent proteinuria in patients with DKD (Journal of Diabetes and Its Complications)
Clinical Manifestations of Kidney Disease Among US Adults With Diabetes, 1988-2014
Among US adults with diabetes from 1988 to 2014, the overall prevalence of diabetic kidney disease did not change significantly, whereas the prevalence of albuminuria declined and the prevalence of reduced eGFR increased (JAMA)
Interactions between kidney disease and diabetes: dangerous liaisons
Understanding the renal physiology and pathophysiology of DKD has become essential to all specialties treating diabetic patients (Diabetology & Metabolic Syndrome)
Individualized prediction of the effect of angiotensin receptor inhibition on renal and cardiovascular outcomes in patients with diabetic nephropathy
The combined effects of ARBs on ESRD and CVD and mortality in patients with diabetic nephropathy varies considerably between patients. A substantial proportion of patients remain at high risk for both outcomes despite ARB treatment (Diabetes, Obesity and Metabolism)
Urinary Biomarkers in the Assessment of Early Diabetic Nephropathy
The concomitant assessment of several urinary biomarkers in relationship with microalbuminuria could represent at present a method of diagnosing early DN. The great progress in discovering new biomarkers could lead to the development of an “ideal” urinary biomarker to detect early diabetic DN in the future (Journal of Diabetes Research)
Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes
In patients with type 2 diabetes at high cardiovascular risk, empagliflozin was associated with slower progression of kidney disease and lower rates of clinically relevant renal events than was placebo when added to standard care (NEJM)
A comparison between angiotensin converting enzyme inhibitors and angiotensin receptor blockers on end stage renal disease and major adverse cardiovascular events in diabetic patients
ACEi compared with ARB was associated with a lower incidence of ESRD, especially in those with CKD. Though ACEi and ARB had a similar risk of composite MACE outcome, ACEi had a slightly higher incidence of stroke than ARB, among the Asian diabetic patients (Cardiovascular Diabetology)
Association Between Plasma Uric Acid Levels and Cardiorenal Function in Adolescents With Type 1 Diabetes
Even within the physiological range, PUA levels were significantly lower in T1D adolescent patients compared with HC subjects. There was an inverse relationship between PUA and eGFR in T1D, likely reflecting an increase in clearance (Diabetes Care)
Immune Cells and Inflammation in Diabetic Nephropathy
In this review, the authors consider the metabolic profile of several relevant immune types and discuss their respective roles (Journal of Diabetes Research)
Non-Alcoholic Fatty Liver Disease Is a Risk Factor for the Development of Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus
NAFLD might be a risk factor for DN. Elevated liver fat content could be associated with higher DN burden (PLoS ONE)
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