Hyperfiltration in Type 1 diabetes is primarily driven by alterations in afferent arteriolar resistance rather than efferent arteriolar resistance. Renal protective therapies should focus on afferent renal arteriolar mechanisms through the use of pharmacological agents that target tubuloglomerular feedback, including sodium-glucose cotransporter 2 inhibitors and incretins (Diabetic Medicine)
Diabetes News
Category: Nephropathy
Soluble CD36 in plasma and urine: a plausible prognostic marker for diabetic nephropathy
Our study implies a plausible prognostic/adjuvant biomarker role of soluble CD36 for diabetic nephropathy (Journal of Diabetes and Its Complications)
Significance of renal biopsy in presumed diabetic nephropathy
These data suggest that, even for patients with long-term DM, renal biopsy should be carried out in patients with presumed DN. Because treatment options differ between DN and primary glomerulopathies, renal biopsy should especially be considered for presumed DN without DR (Journal of Diabetes Investigation)
Urinary Cystatin C & Tubular Proteinuria Predict Progression of DN
The results of this study suggest that urinary cystatin C and NAP may be predictors of the progression of type 2 diabetic nephropathy (Diabetes Care)
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