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Diabetes News

Category: Neuropathy


Micro-controlled thermal stimulator for detecting fine fiber changes in patients with diabetes mellitus: a diagnostic accuracy study

February 2nd 2021

MTS is an accurate, sensitive, and specific instrument for the evaluation of diabetic neuropathy as compared with the tuning fork as the standard method and, consequently, it could be of help for the early diagnosis of diabetic neuropathy (Primary Care Diabetes)

Categories: Neuropathy, News
Tags: diagnostic

Categories: Neuropathy
Tags: diagnostic

Widespread sensory neuropathy in diabetic patients hospitalized with severe COVID-19 infection

December 17th 2020

Severe COVID-19 infection with hypoxemia is associated with neuropathic symptoms and widespread sensory dysfunction in patients with DM (Diabetes Research and Clinical Practice)

Categories: Neuropathy, News
Tags: COVID-19

Categories: Neuropathy
Tags: COVID-19

Population pharmacokinetics of gabapentin in patients with neuropathic pain: lack of effect of diabetes or glycaemic control

October 29th 2020

This PopPK model accurately estimated GBP concentrations in patients with neuropathic pain, using eGFR as a covariate for total clearance. The distribution and excretion processes of GBP were not affected by hyperglycaemia or diabetes (British Journal of Clinical Pharmacology)

Categories: Neuropathy, News
Tags: gabapentin, glycaemic control

Categories: Neuropathy
Tags: gabapentin, glycaemic control

Pain in Patients With Type 2 Diabetes-Related Polyneuropathy Is Associated With Vascular Events and Mortality

July 23rd 2020

Our study found a significant association between pain in DPN and an increased risk of vascular events and mortality (Journal of Clinical Endocrinology & Metabolism)

 

Categories: Neuropathy, News
Tags: mortality, Type 2 Diabetes

Categories: Neuropathy
Tags: mortality, Type 2 Diabetes

Loss of lower extremity muscle strength based on diabetic polyneuropathy in older patients with type 2 diabetes: MUSCLE‐std 2 study

July 14th 2020

DPN clearly reduced LEMS in older type 2 diabetes patients within 4 years. Furthermore, DPN resulted in a loss of LEMS and decrease in mobility. Therefore, DPN development should be monitored closely with glycemic control and LEMS kept at a high level to maintain HRQoL in older patients with type 2 diabetes (Journal of Diabetes Investigation)

Categories: Neuropathy, News
Tags: leg muscle strength, Type 2 Diabetes

Categories: Neuropathy
Tags: leg muscle strength, Type 2 Diabetes

TIR generated by Continuous Glucose Monitoring is associated with peripheral nerve function in type 2 diabetes

June 29th 2020

Higher TIR tertiles were independently associated with better peripheral nerve function. CGM-derived TIR may be a promising approach to screen patients for further assessment of possible diabetic peripheral neuropathy (Diabetes Research and Clinical Practice)

Categories: Neuropathy, News
Tags: CGM, Type 2 Diabetes

Categories: Neuropathy
Tags: CGM, Type 2 Diabetes

Diabetic Neuropathy Collection: Introduction to Diabetic Neuropathy

February 19th 2020

Diabetic Neuropathy podcast (Diabetes Therapy)

Categories: Neuropathy, News
Tags: pod cast

Categories: Neuropathy
Tags: pod cast

Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention

October 15th 2019

In this Review, we appraise innovative point-of-care devices that enable the early diagnosis of DPN and assess the evidence for early risk factor-based management strategies to reduce the incidence and slow the progression of DPN (The Lancet Diabetes & Endocrinology)

Categories: Neuropathy, News
Tags: DPN

Categories: Neuropathy
Tags: DPN

Electrophysiological Characterization of Neuropathy Complicating Type 1 Diabetes Mellitus

July 2nd 2019

These findings signify generation of a protocol for early screening of neuropathy in children with type 1 diabetes (Journal of Diabetes Research)

Categories: Neuropathy, News
Tags: Type 1 Diabetes

Categories: Neuropathy
Tags: Type 1 Diabetes

Pregabalin in the Management of Painful Diabetic Neuropathy: A Narrative Review

December 18th 2018

This review evaluates the role of pregabalin in the management of pDPN as well as its potential adverse effects, such as somnolence and dizziness, which can lead to withdrawal in ~ 30% of long-term use (Diabetes Therapy)

Categories: Neuropathy
Tags: pregabalin

Neuropad for detecting preclinical diabetic peripheral neuropathy

September 13th 2018

The case for adopting Neuropad to detect preclinical diabetic peripheral neuropathy is not supported by the evidence (NICE)

Categories: Neuropathy, News
Tags: Neuropad, peripheral neuropathy

Categories: Neuropathy
Tags: Neuropad, peripheral neuropathy

Reduced vitamin D levels in painful diabetic peripheral neuropathy

August 17th 2018

We have demonstrated a significant difference in 25‐hydroxyvitamin D levels in well‐characterized people with painful diabetic peripheral neuropathy, while accounting for the main confounding factors. This suggests a possible role for vitamin D in the pathogenesis of painful diabetic peripheral neuropathy (Diabetic Medicine)

Categories: Neuropathy, News
Tags: Vitamin D

Categories: Neuropathy
Tags: Vitamin D

Interactions between and Shared Molecular Mechanisms of Diabetic Peripheral Neuropathy and Obstructive Sleep Apnea in Type 2 Diabetes Patients

July 19th 2018

In this review, we seek to illuminate the relationships among T2D, diabetic peripheral neuropathy, and OSA and how they interact with one another  (Journal of Diabetes Research)

Categories: Neuropathy, News
Tags: Obstructive Sleep Apnea, Type 2 Diabetes

Categories: Neuropathy
Tags: Obstructive Sleep Apnea, Type 2 Diabetes

Risk-Factor Trajectories Preceding Diabetic Polyneuropathy: ADDITION-Denmark

July 10th 2018

Both higher levels and slopes of HbA1c trajectories were associated with DPN after 13 years. Our findings indicate that the rate of HbA1c increase affects the development of DPN over and above the effect of the HbA1c level. Furthermore, this study supports obesity as a risk factor for DPN (Diabetes Care)

Categories: Neuropathy, News
Tags: polyneuropathy

Categories: Neuropathy
Tags: polyneuropathy

Dulaglutide versus insulin glargine in patients with type 2 diabetes and moderate-to-severe chronic kidney disease (AWARD-7)

June 15th 2018

In patients with type 2 diabetes and moderate-to-severe chronic kidney disease, once-weekly dulaglutide produced glycaemic control similar to that achieved with insulin glargine, with reduced decline in eGFR. Dulaglutide seems to be safe to use to achieve glycaemic control in patients with moderate-to-severe chronic kidney disease (The Lancet Diabetes & Endocrinology)

Categories: Neuropathy, News
Tags: Dulaglutide, glargine, insulin, Type 2 Diabetes

Categories: Neuropathy
Tags: Dulaglutide, glargine, insulin, Type 2 Diabetes

Neuropathic pain in adults: pharmacological management in non-specialist settings

May 18th 2018

The guideline sets out how drug treatments for neuropathic pain differ from traditional pain management (NICE)

Categories: Neuropathy, News
Tags: pain, pharmacological

Categories: Neuropathy
Tags: pain, pharmacological

HbA1c variability and diabetic peripheral neuropathy in type 2 diabetic patients

April 13th 2018

Increased HbA1c variability is closely associated with DPN in type 2 diabetic patients and could be considered as a potent indicator for DPN in these patients (BMC Health Services Research)

Categories: Neuropathy, News
Tags: HbA1c, Type 2 Diabetes

Categories: Neuropathy
Tags: HbA1c, Type 2 Diabetes

Painful and painless neuropathies are distinct and largely undiagnosed entities in subjects participating in an educational initiative (PROTECT Study)

March 6th 2018

Around half of participants in an educational initiative had DSPN, 62% of whom had the painful entity that correlated with BMI in T2D. Since many cases of neuropathy and diabetes remain undiagnosed, effective strategies to timely detect both conditions should be implemented (Diabetes Research and Clinical Practice)

Categories: Neuropathy, News
Tags: diagnosis, peripheral, Type 2 Diabetes

Categories: Neuropathy
Tags: diagnosis, peripheral, Type 2 Diabetes

The Role of Oxidative Stress, Mitochondrial Function, and Autophagy in Diabetic Polyneuropathy

October 24th 2017

Clarification of the mechanisms involved in the appearance of complications in DM will facilitate the selection of specific therapeutic options based on the mechanisms involved in the metabolic pathways affected (Journal of Diabetes Research)

Categories: Neuropathy, News
Tags: autophagy, oxidative stress

Categories: Neuropathy
Tags: autophagy, oxidative stress

Neuropathic pain in adults: pharmacological management in non-specialist settings

February 23rd 2017

This guideline covers managing neuropathic pain (nerve pain) with pharmacological treatments (drugs) in adults in non-specialist settings. It aims to improve quality of life for people with conditions such as neuralgia, shingles and diabetic neuropathy by reducing pain and promoting increased participation in all aspects of daily living (NICE)

Categories: Neuropathy, News
Tags: NICE, pharmacological

Categories: Neuropathy
Tags: NICE, pharmacological
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