In this scenario, the genetics of microRNAs is at a very preliminary stage. Notwithstanding, the study of genetics and epigenetics of miRNAs may well contribute to the identification of exploratory biomarkers of risk and pathogenetic mechanisms of diabetic neuropathy and to a comprehensive definition of susceptibility to specific pathogenetic mechanisms to favor a tailored mechanism-based treatment or prevention (Journal of Diabetes Research)
Diabetes News
Category: Neuropathy
Dipeptidyl peptidase-4 inhibitor and insulin combination treatment in type 2 diabetes and chronic kidney disease: a meta-analysis
This study demonstrated the effectiveness and safety of DPP-4 inhibitors bonded with insulin in patients with T2D and CKD, but the protective actions of this cure on kidney and cardiovascular outcomes, as well as the functions of other DPP-4 inhibitors, need to be affirmed by more good-quality RCTs (Journal of Diabetes Investigation)
Neuron-specific biomarkers predict hypo- and hyperalgesia in individuals with diabetic peripheral neuropathy
This study introduces a dynamic and non-invasive assessment strategy for the underlying pathogenesis of diabetic peripheral neuropathy (Diabetologia)
Association of glycemic variability assessed by continuous glucose monitoring with subclinical diabetic polyneuropathy in type 2 diabetes
The SDgluc is a significant independent contributor to subclinical diabetic polyneuropathy, in addition to conventional risk factors including diabetes duration and HbA1c (Journal of Diabetes Investigation)
Relationship between Hyponatremia and Peripheral Neuropathy in Patients with Diabetes
Low serum sodium levels were independently associated with DPN, even within the normal range of the serum sodium. We should pay more attention to avoid the low serum sodium level in patients with type 2 diabetes mellitus (Journal of Diabetes Research)
A New Clinical Utility For Tubular Markers To Identify Kidney Responders To Saxagliptin Treatment In Patients With Diabetic Nephropathy
The albuminuria-lowering effect of saxagliptin may be due to inhibition of kidney tubular damage. The use of tubular markers may be regarded as a promising tool to identify kidney responders to gliptins (Canadian Journal of Diabetes)
Whole plantar nerve conduction study: a new tool for early diagnosis of peripheral diabetic neuropathy
Our data support WPN conduction study reliability in characterizing the most distal sensory nerve fibers at lower limbs. Thus, WPN may represent an extremely useful diagnostic tool for diabetic PN early detection (Diabetes Research and Clinical Practice)
Pedobarographic Statistical Parametric Mapping may identify specific plantar pressure patterns in patients with diabetes mellitus among different degrees of peripheral neuropathy: a pilot study
pSPM may identify specific features of plantar pressure distribution during walking in patients with mild PN and may become a useful screening tool for a timely identification of this complication (Diabetic Medicine)
Micro-controlled thermal stimulator for detecting fine fiber changes in patients with diabetes mellitus: a diagnostic accuracy study
MTS is an accurate, sensitive, and specific instrument for the evaluation of diabetic neuropathy as compared with the tuning fork as the standard method and, consequently, it could be of help for the early diagnosis of diabetic neuropathy (Primary Care Diabetes)
Widespread sensory neuropathy in diabetic patients hospitalized with severe COVID-19 infection
Severe COVID-19 infection with hypoxemia is associated with neuropathic symptoms and widespread sensory dysfunction in patients with DM (Diabetes Research and Clinical Practice)
Population pharmacokinetics of gabapentin in patients with neuropathic pain: lack of effect of diabetes or glycaemic control
This PopPK model accurately estimated GBP concentrations in patients with neuropathic pain, using eGFR as a covariate for total clearance. The distribution and excretion processes of GBP were not affected by hyperglycaemia or diabetes (British Journal of Clinical Pharmacology)
Pain in Patients With Type 2 Diabetes-Related Polyneuropathy Is Associated With Vascular Events and Mortality
Our study found a significant association between pain in DPN and an increased risk of vascular events and mortality (Journal of Clinical Endocrinology & Metabolism)
Loss of lower extremity muscle strength based on diabetic polyneuropathy in older patients with type 2 diabetes: MUSCLE‐std 2 study
DPN clearly reduced LEMS in older type 2 diabetes patients within 4 years. Furthermore, DPN resulted in a loss of LEMS and decrease in mobility. Therefore, DPN development should be monitored closely with glycemic control and LEMS kept at a high level to maintain HRQoL in older patients with type 2 diabetes (Journal of Diabetes Investigation)
TIR generated by Continuous Glucose Monitoring is associated with peripheral nerve function in type 2 diabetes
Higher TIR tertiles were independently associated with better peripheral nerve function. CGM-derived TIR may be a promising approach to screen patients for further assessment of possible diabetic peripheral neuropathy (Diabetes Research and Clinical Practice)
Diabetic Neuropathy Collection: Introduction to Diabetic Neuropathy
Diabetic Neuropathy podcast (Diabetes Therapy)
Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention
In this Review, we appraise innovative point-of-care devices that enable the early diagnosis of DPN and assess the evidence for early risk factor-based management strategies to reduce the incidence and slow the progression of DPN (The Lancet Diabetes & Endocrinology)
Electrophysiological Characterization of Neuropathy Complicating Type 1 Diabetes Mellitus
These findings signify generation of a protocol for early screening of neuropathy in children with type 1 diabetes (Journal of Diabetes Research)
Pregabalin in the Management of Painful Diabetic Neuropathy: A Narrative Review
This review evaluates the role of pregabalin in the management of pDPN as well as its potential adverse effects, such as somnolence and dizziness, which can lead to withdrawal in ~ 30% of long-term use (Diabetes Therapy)
Neuropad for detecting preclinical diabetic peripheral neuropathy
The case for adopting Neuropad to detect preclinical diabetic peripheral neuropathy is not supported by the evidence (NICE)
Reduced vitamin D levels in painful diabetic peripheral neuropathy
We have demonstrated a significant difference in 25‐hydroxyvitamin D levels in well‐characterized people with painful diabetic peripheral neuropathy, while accounting for the main confounding factors. This suggests a possible role for vitamin D in the pathogenesis of painful diabetic peripheral neuropathy (Diabetic Medicine)
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