The algorithm demonstrated safe levels of sensitivity for high-risk retinopathy in a real-world screening service, with specificity that could halve the workload for human graders (British Journal of Ophthalmology)
Diabetes News
Category: Ophthalmology
Incidence of sight threatening diabetic retinopathy in an established urban screening programme: an 11‐year cohort study
In an established screening programme with a stable population screen positive rates show a consistent fall over time to a low level. Of those who are screen positive, fewer than 50% are screen positive for DR. Most are due to sight threatening maculopathy (Diabetic Medicine)
The contribution of the English NHS Diabetic Eye Screening Programme to reductions in diabetes-related blindness, comparisons within Europe, and future challenges
Current plans for NHS DESP include extension of screening intervals in low-risk groups and the introduction of optical coherence tomography as a second line of screening for those with screen positive maculopathy with two dimensional markers. Future challenges include the introduction of automated analysis for grading and new camera technologies (Acta Diabetologica)
Abnormal N-Glycosylation of Human Lens Epithelial Cells in Type-2 Diabetes May Contribute to Cataract Progression
These results suggest that over-expression of N-glycosidically linked human type 1 cytokeratin may induce capsule disruption and affect selective permeability, allowing the entry of different molecules to the lens that facilitate cataract progression (Clinical Ophthalmology)
The Role of SGLT2 Inhibitor on the Treatment of Diabetic Retinopathy
Recent studies have found that SGLT2 is also expressed in the human retina. Now, the prevention and treatment of diabetic retinopathy with SGLT2i while reducing blood sugar has become a new research field. Hence, this article reviewed the recent therapeutic and research progress of SGLT2 in the treatment of diabetic retinopathy (Journal of Diabetes Research)
Different retinopathy phenotypes in type 2 diabetes predict retinopathy progression
Different DR phenotypes in type 2 diabetes show different risks of retinopathy progression. Phenotype C is associated with increased HbA1c values and presents a higher risk of a 2-or-more-step worsening of the ETDRS severity score (Acta Diabetologica)
Patrolling Monocytes Are Recruited and Activated By Diabetes To Protect Retinal Microvessels
Thus, after short diabetes duration, PMo are the cells preferentially recruited to the retinal vessels and protect vessels from diabetic damage (Diabetes)
The unique association between the level of peripheral blood monocytes and the prevalence of diabetic retinopathy: a cross-sectional study
Decreased peripheral blood monocyte levels were associated with increased odds of DR after adjusting for potential confounders in diabetic adults. However, causation remains to be demonstrated(Journal of Translational Medicine)
Eye care providers’ emerging roles in early detection of diabetes and management of diabetic changes to the ocular surface: a review
Recent ophthalmic research has identified multiple subclinical and clinical changes that occur in the anterior segment of the eye with metabolic disease (BMJ)
Retinopathy develops at similar glucose levels but higher HbA1c levels in people with black African ancestry compared to white European ancestry: evidence for the need to individualize HbA1c interpretation
Since retinopathy occurs at higher HbA1c levels in black people for a given level of average plasma glucose, strategies may be needed to individualize the interpretation of HbA1c measurements (Diabetic Medicine)
How to perform better intervention to prevent and control diabetic retinopathy among patients with type 2 diabetes: A meta-analysis of randomized controlled trials
We found that multifactorial interventions can significantly reduce the risk of developing DR and its progression among patients with type 2 diabetes. More importantly, we found all these multifactorial interventions contained individualization of targets and communication between health professionals and patients, suggesting ophthalmologists and diabetes health professionals should work together with patients to set more individualized targets while taking into account multiple factors so as to achieve optimal effect in DR prevention and control (Diabetes Research and Clinical Practice)
Angiopoietins in Diabetic Retinopathy: Current Understanding and Therapeutic Potential
The function of the Ang proteins in regulating blood vessel permeability and neovascularisation is discussed, and we also evaluate recent preclinical and clinical studies highlighting the potential benefits of modulating Ang signalling as a treatment for DR (Journal of Diabetes Research)
Oxidative Stress as the Main Target in Diabetic Retinopathy Pathophysiology
In this review, we propose oxidative stress as the focus point of this complication onset (Journal of Diabetes Research)
Vulnerabilities in diabetic eye screening for children and young people in England
There is limited direct communication between the services involved in diabetic eye care for CYP in England. This risks reducing the effectiveness of diabetic retinopathy screening. Similar vulnerabilities are likely to exist in other countries where retinopathy screening for CYP has been ‘bolted on’ to provision for adults (Pediatric Research)
Retinopathy Outcomes With Empagliflozin Versus Placebo in the EMPA-REG OUTCOME Trial
Empagliflozin also reduced the risk of a prespecified microvascular outcome (composite of time to first initiation of retinal photocoagulation, vitreous hemorrhage, diabetes-related blindness, or incident/worsening nephropathy) by 38% versus placebo (Diabetes Care)
The prevalence of retinopathy in patients with type 1 diabetes treated with education-based intensified insulin therapy and its association with parameters of glucose control
In type 1 diabetes EBIIT is associated with good diabetes control and a low prevalence of DR. The cumulative glucose exposure over time given as HbA1c years is the best predictor for development of DR (Diabetes Research and Clinical Practice)
Applicability of telemedicine in the screening of diabetic retinopathy (DR): The first multicentre study in Italy. The No Blind Study
Our findings, in an Italian setting, confirm main data in the literature about DR prevalence. Hence, telemedicine could represent an accurate, fast and cheap method for screening of DR (Diabetes/Metabolism Research and Reviews)
Anti‐vascular endothelial growth factor for diabetic macular oedema: a network meta‐analysis
Anti‐VEGF drugs are effective at improving vision in people with DMO with three to four in every 10 people likely to experience an improvement of 3 or more lines VA at one year (Cochrane Database of Systematic Reviews)
Association between diabetic eye disease and other complications of diabetes: implications for care. A systematic review
This analysis highlights the need for a coordinated and collaborative approach to patient management. Given the widespread use of DR screening programs that can be performed outside of an ophthalmology office, and the overall cost‐effectiveness of DR screening, the presence and severity of DR can act as a means of identifying patients at increased risk for micro‐ and macro‐vascular complications, enabling earlier detection, referral, and intervention with the aim of reducing morbidity and mortality among patients with diabetes (Diabetes, Obesity and Metabolism)
Longitudinal relationship between retinal diabetic neurodegeneration and progression of diabetic retinopathy in patients with type 2 diabetes
Progressive loss of mGCIPL is an independent risk factor for progression in early-stage DR. Further assessment of autonomic and peripheral nerve functions can increase sensitivity in predicting aggravation of DR in patients with T2DM (American Journal of Ophthalmology)
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