The presence and degree of DR are independent predictors of severe coronary atherosclerosis. Therefore, when evaluating whether a patient with T2DM is at high risk for CAD, the DR degree should be taken into consideration (Metabolic Syndrome and Obesity)
Diabetes News
Category: Ophthalmology
Pre-existing diabetic retinopathy as a prognostic factor for covid-19 outcomes amongst people with diabetes: a systematic review
The current literature suggests an independent association between DR and poorer COVID-19 prognosis in patients with DM after controlling for key variables such as age (Diabetes Research and Clinical Practice)
Relationship Between Muscle Cramps and Diabetic Retinopathy in Patients with Type 2 Diabetes
Muscle cramps occur frequently in diabetes and are correlated with diabetic retinopathy and albumin. Patients with PDR exhibited a higher frequency, severity, and longer duration relative to those with NPDR or without DR (Metabolic Syndrome and Obesity)
Suprachoroidal versus Intravitreal Triamcinolone Acetonide for the Treatment of Diabetic Macular Edema
SCTA is a safe and effective route for the treatment of DME, which has comparable effects to IVTA, and may even last longer (Clinical Ophthalmology)
Oxurion Announces New Data on THR-149 Phase 2 Clinical Trial (“KALAHARI”) in DME
Post-hoc analysis reveals >9 letter gain in mean BCVA that was maintained for the remaining four months of the trial after the last THR-149 injection with no rescue treatment required
These gains were seen in patients that are part of the 40-50% of DME patients that suboptimally respond to standard of care anti-VEGF therapy (Oxurion)
Metformin and risk of age-related macular degeneration in individuals with type 2 diabetes: a retrospective cohort study
We found no evidence that metformin was associated with risk of AMD in primary care patients requiring treatment for type 2 diabetes (BMJ)
Use of Anthropometric Measures of Obesity to Predict Diabetic Retinopathy in Patients with Type 2 Diabetes in China
WHtR and BMI but not WHR are risk factors for DR in obese patients with T2D. Patients with high WHtR and BMI should be closely monitored to prevent the development of DR (Diabetes, Metabolic Syndrome and Obesity)
Association of maternal diabetes during pregnancy with high refractive error in offspring: a nationwide population-based cohort study
Our findings suggest that maternal diabetes during pregnancy is associated with an increased risk of high RE in offspring, in particular among those of mothers with diabetic complications (Diabetologia)
Bacterial infections as novel risk factors of severe diabetic retinopathy in individuals with type 1 diabetes
Bacterial infections are associated with an increased risk of incident SDR in type 1 diabetes (British Journal of Ophthalmology)
Prospective evaluation of an artificial intelligence-enabled algorithm for automated diabetic retinopathy screening of 30 000 patients
The algorithm demonstrated safe levels of sensitivity for high-risk retinopathy in a real-world screening service, with specificity that could halve the workload for human graders (British Journal of Ophthalmology)
Incidence of sight threatening diabetic retinopathy in an established urban screening programme: an 11‐year cohort study
In an established screening programme with a stable population screen positive rates show a consistent fall over time to a low level. Of those who are screen positive, fewer than 50% are screen positive for DR. Most are due to sight threatening maculopathy (Diabetic Medicine)
The contribution of the English NHS Diabetic Eye Screening Programme to reductions in diabetes-related blindness, comparisons within Europe, and future challenges
Current plans for NHS DESP include extension of screening intervals in low-risk groups and the introduction of optical coherence tomography as a second line of screening for those with screen positive maculopathy with two dimensional markers. Future challenges include the introduction of automated analysis for grading and new camera technologies (Acta Diabetologica)
Abnormal N-Glycosylation of Human Lens Epithelial Cells in Type-2 Diabetes May Contribute to Cataract Progression
These results suggest that over-expression of N-glycosidically linked human type 1 cytokeratin may induce capsule disruption and affect selective permeability, allowing the entry of different molecules to the lens that facilitate cataract progression (Clinical Ophthalmology)
The Role of SGLT2 Inhibitor on the Treatment of Diabetic Retinopathy
Recent studies have found that SGLT2 is also expressed in the human retina. Now, the prevention and treatment of diabetic retinopathy with SGLT2i while reducing blood sugar has become a new research field. Hence, this article reviewed the recent therapeutic and research progress of SGLT2 in the treatment of diabetic retinopathy (Journal of Diabetes Research)
Different retinopathy phenotypes in type 2 diabetes predict retinopathy progression
Different DR phenotypes in type 2 diabetes show different risks of retinopathy progression. Phenotype C is associated with increased HbA1c values and presents a higher risk of a 2-or-more-step worsening of the ETDRS severity score (Acta Diabetologica)
Patrolling Monocytes Are Recruited and Activated By Diabetes To Protect Retinal Microvessels
Thus, after short diabetes duration, PMo are the cells preferentially recruited to the retinal vessels and protect vessels from diabetic damage (Diabetes)
The unique association between the level of peripheral blood monocytes and the prevalence of diabetic retinopathy: a cross-sectional study
Decreased peripheral blood monocyte levels were associated with increased odds of DR after adjusting for potential confounders in diabetic adults. However, causation remains to be demonstrated(Journal of Translational Medicine)
Eye care providers’ emerging roles in early detection of diabetes and management of diabetic changes to the ocular surface: a review
Recent ophthalmic research has identified multiple subclinical and clinical changes that occur in the anterior segment of the eye with metabolic disease (BMJ)
Retinopathy develops at similar glucose levels but higher HbA1c levels in people with black African ancestry compared to white European ancestry: evidence for the need to individualize HbA1c interpretation
Since retinopathy occurs at higher HbA1c levels in black people for a given level of average plasma glucose, strategies may be needed to individualize the interpretation of HbA1c measurements (Diabetic Medicine)
How to perform better intervention to prevent and control diabetic retinopathy among patients with type 2 diabetes: A meta-analysis of randomized controlled trials
We found that multifactorial interventions can significantly reduce the risk of developing DR and its progression among patients with type 2 diabetes. More importantly, we found all these multifactorial interventions contained individualization of targets and communication between health professionals and patients, suggesting ophthalmologists and diabetes health professionals should work together with patients to set more individualized targets while taking into account multiple factors so as to achieve optimal effect in DR prevention and control (Diabetes Research and Clinical Practice)
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