In a national cohort of 205,970 patients, almost half of the patients attended DR screening later than scheduled or dropped out after first screening episode. This was, in particular, true for patients with any levels of DR at baseline. DR progression in patients with delayed attendance, increased with the number of missed appointments (Acta Diabetologica)
Diabetes News
Category: Ophthalmology
Digital innovations for retinal care in diabetic retinopathy
Advances in digital health have created an ecosystem ripe for telemedicine in the field of DR to thrive. Stakeholders and policymakers should adopt a participatory approach to ensure sustained implementation of these technologies after the COVID-19 pandemic (Acta Diabetologica)
Diabetic retinopathy screening in the emerging era of artificial intelligence
Although clinically implemented AI-based diabetic retinopathy screening, integration of mobile devices and ocular telemedicine are still in their infancy, the technology is evolving rapidly and there is little doubt that these concepts will be able to optimise diabetic retinopathy screening within a few years (Diabetologia)
Retinal microvascular associations with cardiometabolic risk factors differ by diabetes status: results from the UK Biobank
We provide clear evidence of the modifying effect of diabetes on cardiometabolic risk factor associations with retinal microvascular architecture. These observations suggest the occurrence of preclinical disease processes, and may be a sign of impaired autoregulation due to hyperglycaemia, which has been suggested to play a pivotal role in the development of diabetes-related microvascular complications (Diabetologia)
Abnormalities of the oculomotor function in type 1 diabetes and diabetic neuropathy
Abnormalities in oculomotor system function can be detected in patients with type 1 diabetes using a novel eye-tracking-based test. A larger cohort study may further determine thresholds of normality and validate whether eye-tracking can be used to non-invasively characterize early signs of diabetic neuropathy (Acta Diabetologica)
Diabetic Retinopathy as a Predictor of Angiographic Coronary Atherosclerosis Severity in Patients with Type 2 Diabetes Mellitus
The presence and degree of DR are independent predictors of severe coronary atherosclerosis. Therefore, when evaluating whether a patient with T2DM is at high risk for CAD, the DR degree should be taken into consideration (Metabolic Syndrome and Obesity)
Pre-existing diabetic retinopathy as a prognostic factor for covid-19 outcomes amongst people with diabetes: a systematic review
The current literature suggests an independent association between DR and poorer COVID-19 prognosis in patients with DM after controlling for key variables such as age (Diabetes Research and Clinical Practice)
Relationship Between Muscle Cramps and Diabetic Retinopathy in Patients with Type 2 Diabetes
Muscle cramps occur frequently in diabetes and are correlated with diabetic retinopathy and albumin. Patients with PDR exhibited a higher frequency, severity, and longer duration relative to those with NPDR or without DR (Metabolic Syndrome and Obesity)
Suprachoroidal versus Intravitreal Triamcinolone Acetonide for the Treatment of Diabetic Macular Edema
SCTA is a safe and effective route for the treatment of DME, which has comparable effects to IVTA, and may even last longer (Clinical Ophthalmology)
Oxurion Announces New Data on THR-149 Phase 2 Clinical Trial (“KALAHARI”) in DME
Post-hoc analysis reveals >9 letter gain in mean BCVA that was maintained for the remaining four months of the trial after the last THR-149 injection with no rescue treatment required
These gains were seen in patients that are part of the 40-50% of DME patients that suboptimally respond to standard of care anti-VEGF therapy (Oxurion)
Metformin and risk of age-related macular degeneration in individuals with type 2 diabetes: a retrospective cohort study
We found no evidence that metformin was associated with risk of AMD in primary care patients requiring treatment for type 2 diabetes (BMJ)
Use of Anthropometric Measures of Obesity to Predict Diabetic Retinopathy in Patients with Type 2 Diabetes in China
WHtR and BMI but not WHR are risk factors for DR in obese patients with T2D. Patients with high WHtR and BMI should be closely monitored to prevent the development of DR (Diabetes, Metabolic Syndrome and Obesity)
Association of maternal diabetes during pregnancy with high refractive error in offspring: a nationwide population-based cohort study
Our findings suggest that maternal diabetes during pregnancy is associated with an increased risk of high RE in offspring, in particular among those of mothers with diabetic complications (Diabetologia)
Bacterial infections as novel risk factors of severe diabetic retinopathy in individuals with type 1 diabetes
Bacterial infections are associated with an increased risk of incident SDR in type 1 diabetes (British Journal of Ophthalmology)
Prospective evaluation of an artificial intelligence-enabled algorithm for automated diabetic retinopathy screening of 30 000 patients
The algorithm demonstrated safe levels of sensitivity for high-risk retinopathy in a real-world screening service, with specificity that could halve the workload for human graders (British Journal of Ophthalmology)
Incidence of sight threatening diabetic retinopathy in an established urban screening programme: an 11‐year cohort study
In an established screening programme with a stable population screen positive rates show a consistent fall over time to a low level. Of those who are screen positive, fewer than 50% are screen positive for DR. Most are due to sight threatening maculopathy (Diabetic Medicine)
The contribution of the English NHS Diabetic Eye Screening Programme to reductions in diabetes-related blindness, comparisons within Europe, and future challenges
Current plans for NHS DESP include extension of screening intervals in low-risk groups and the introduction of optical coherence tomography as a second line of screening for those with screen positive maculopathy with two dimensional markers. Future challenges include the introduction of automated analysis for grading and new camera technologies (Acta Diabetologica)
Abnormal N-Glycosylation of Human Lens Epithelial Cells in Type-2 Diabetes May Contribute to Cataract Progression
These results suggest that over-expression of N-glycosidically linked human type 1 cytokeratin may induce capsule disruption and affect selective permeability, allowing the entry of different molecules to the lens that facilitate cataract progression (Clinical Ophthalmology)
The Role of SGLT2 Inhibitor on the Treatment of Diabetic Retinopathy
Recent studies have found that SGLT2 is also expressed in the human retina. Now, the prevention and treatment of diabetic retinopathy with SGLT2i while reducing blood sugar has become a new research field. Hence, this article reviewed the recent therapeutic and research progress of SGLT2 in the treatment of diabetic retinopathy (Journal of Diabetes Research)
Different retinopathy phenotypes in type 2 diabetes predict retinopathy progression
Different DR phenotypes in type 2 diabetes show different risks of retinopathy progression. Phenotype C is associated with increased HbA1c values and presents a higher risk of a 2-or-more-step worsening of the ETDRS severity score (Acta Diabetologica)
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