This article, aims to provide a practical approach and help identify which patients may be most likely to benefit and how the technology may be implemented in order to maximise the clinical benefits (Diabetes Research and Clinical Practice)
Diabetes News
Category: Paediatrics
Diabetes (type 1 and type 2) in children and young people: diagnosis and management – glucose monitoring
Consultation documents (NICE)
Metformin for pediatric obesity and insulin resistance: a retrospective study within an integrated health care system
Metformin with lifestyle interventions significantly reduced weight, BMI, and BMI z score in pediatric patients with obesity and insulin resistance up to 24 months, compared with intensive and routine counseling alone (Obesity)
Motivational Stage at CGM Initiation in Pediatric Type 1 Diabetes is Associated with Current Glycemic Control but does not Predict Future CGM Adherence or Glycemic Control
SOCRATES can categorize children with type 1 diabetes and their parents into motivational stages. While motivational stage was associated with glycemic control at trial entry, it did not predict future diabetes-related behaviour or HbA1c (Canadian Journal of Diabetes)
Psychosocial Outcomes in Young Adolescents with Type 1 Diabetes Participating in Shared Medical Appointments
Participation in Team Clinic was associated with improved psychosocial outcomes in middle school‐aged participants with T1D (Pediatric Diabetes)
Comprehensive Psychosocial Screening in a Pediatric Diabetes Clinic
Comprehensive psychosocial screening can be effectively implemented as part of routine pediatric diabetes care and can identify adolescents in need of additional supports (Pediatric Diabetes)
Diabetes (type 1 and type 2) in children and young people: diagnosis and management
This guideline covers the diagnosis and management of type 1 and type 2 diabetes in children and young people aged under 18 (NICE)
Relationship of glycemic derangement using continuous glucose monitoring system with sleep pattern among children with type 1 diabetes mellitus
Clinically significant hypoglycemia is associated with sleep deepening, while hyperglycemia is associated with increased light sleep, sleep onset latency, AI among C‐T1D (Diabetes/Metabolism Research and Reviews)
Temporal Trend in Young-Onset Type 2 Diabetes—the Macrovascular and Mortality Risk: Study of U.K. Primary Care Electronic Medical Records
Unlike usual-onset, young-onset type 2 diabetes has a similar cardiovascular and mortality risk irrespective of cardiometabolic risk factor status at diagnosis. The guidelines on the management of young-onset type 2 diabetes for intensive risk factor management and cardioprotective therapies need to be urgently reevaluated through prospective studies (Diabetes Care)
BSPED Interim Guideline for the Management of Children and Young People under the age of 18 years with Diabetic Ketoacidosis
These BSPED guidelines are believed to be as safe as possible in the light of current evidence.However, no guidelines can be considered entirely safe as complications may still arise. In particularthe pathophysiology of cerebral oedema is still poorly understood (the British Society for Paediatric Endocrinology and Diabetes)
Educational and Health Outcomes of Children Treated for Type 1 Diabetes: Scotland-Wide Record Linkage Study of 766,047 Children
Children with type 1 diabetes fare worse than their peers in respect of education and health outcomes, especially if they have higher mean HbA1c. Interventions are required to minimize school absence and ensure that it does not affect educational attainment (Diabetes Care)
Inequalities in glycaemic control in childhood onset type 2 diabetes in England and Wales – A national population‐based longitudinal study
About two thirds of children with childhood‐onset T2D were non‐White, female adolescents, just under half of whom live in the most disadvantaged areas of England and Wales. Additionally, there are substantial socioeconomic and ethnic inequalities in diabetes control (Pediatric Diabetes)
Diabetes (type 1 and type 2) in children and young people: diagnosis and management
The guideline recommends strict targets for blood glucose control to reduce the long-term risks associated with diabetes (NICE)
Pancreas size and exocrine function is decreased in young children with recent‐onset Type 1 diabetes
Pancreatic area and accompanying subclinical exocrine function were reduced in very young children with recent‐onset Type 1 diabetes. This supports changes in the exocrine pancreas in the pathophysiology of Type 1 diabetes presenting in early life (Diabetic Medicine)
Liraglutide in Children and Adolescents with Type 2 Diabetes
In children and adolescents with type 2 diabetes, liraglutide, at a dose of up to 1.8 mg per day (added to metformin, with or without basal insulin), was efficacious in improving glycemic control over 52 weeks. This efficacy came at the cost of an increased frequency of gastrointestinal adverse events (NEJM)
Is there an optimal strategy for real‐time continuous glucose monitoring in pediatrics? A 12‐month French multi‐center, prospective, controlled randomized trial (Start‐In!)
None of the three long‐term RT‐CGM strategies evaluated in pediatric type 1 diabetes was superior to the others in terms of HbA1c levels. CGM‐use for three months decreased rates of severe hypoglycemia. Our results confirm the feasibility of long‐term RT‐CGM‐use and the need to improve educational support for patients and caregivers (Pediatric Diabetes)
Youth-Onset Type 2 Diabetes and the Developing Brain
Youth with type 2 diabetes demonstrate lower cognitive scores and structural brain differences. Although causality has not yet been established, these findings are important because these individuals are still undergoing neurodevelopmental maturation (Current Diabetes Reports)
Predicting Progression to Type 1 Diabetes from Ages 3 to 6 in Islet Autoantibody Positive TEDDY Children
This study highlights the application of precision medicine techniques to predict progression to diabetes over a 3‐year window in TEDDY subjects. This multifaceted model provides preliminary improvement in prediction over simpler prediction tools. Additional tools are needed to maximize the predictive value of these approaches (Pediatric Diabetes)
Individual glucose responses to prolonged moderate intensity aerobic exercise in adolescents with type 1 diabetes: The higher they start, the harder they fall
Youth with T1D have variable glycemic responses to prolonged aerobic exercise, but this variability is partially explained by their pre‐exercise blood glucose levels. When no implementation strategies are in place to limit the drop in glycemia, the incidence of exercise‐associated hypoglycemia is ~44% and having a high pre‐exercise blood glucose concentration is only marginally protective (Pediatric Diabetes)
Evaluation and Management of Youth-Onset Type 2 Diabetes: A Position Statement by the American Diabetes Association
Although all types of diabetes result in hyperglycemia, the pathophysiology of each type of diabetes is different. These guidelines summarize available data specific to the comprehensive care of youth with type 2 diabetes (Diabetes Care)
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