Glucosepane is a novel AGE marker of diabetic complications that is robustly associated with nephropathic, retinopathic and neuropathic outcomes despite adjustment for A1c, suggesting that it could be one mediator of these complications with possible diagnostic implications (Diabetes and Its Complications)
Diabetes News
Glycosmedia is dedicated to bringing free, non-promotional, editorially independent news to a global audience about developments in diabetes, and is primarily aimed at health professionals.
Gene Expression Dynamics during Diabetic Periodontitis
diabetes-enhanced inflammation both up- and down-regulates genes involved in cellular activity and cell signaling, while it predominantly up-regulates genes involved in the host response, apoptosis, and coagulation/homeostasis/complement and down-regulates mRNA levels of neuron, retina, and energy/metabolism-associated genes (Journal of Dental Research)
FORXIGA™ approved in EU for treatment of T2D
FORXIGA is a selective and reversible inhibitor of sodium-glucose cotransporter 2 (SGLT2) that works independently of insulin to help remove excess glucose from the body, a unique mode of action not seen in any other currently available treatments for type 2 diabetes (AstraZeneca and Bristol-Myers Squibb)
A Simple Screening Method for Individuals at Risk of Developing T1D
Measurement of Islet Cell Autoantibodies (GADA, IA-2A, and IAA) on Dried Capillary Blood Spots Collected on Filter Paper (Human and Metabolic Research)
Long-Acting Insulins Win FDA Panel Support
An FDA advisory committee voted 8-4 Thursday in favor of approval of a new ultra-long-acting insulin for type 1 and type 2 diabetes. (medpage TODAY)
Type 2 diabetes: insulin degludec
This evidence summary considers the use of insulin degludec in adults with type 2 diabetes (NICE)
Type 1 diabetes: insulin degludec
This evidence summary considers the use of insulin degludec in adults with type 1 diabetes (NICE)
The management of adult diabetes services in the NHS
Seventeenth Report of Session 2012–13. together with formal minutes, oral and written evidence (House of Commons, UK)
Insulin pharmacodynamic profile & a novel infusion site warming device
Our results show that insulin infusion site warming with InsuPatch activation accelerates the time action profile of aspart insulin which may be of benefit to current open-loop and future closed-loop insulin delivery in patients with T1D (Pediatric Diabetes)
Cardiovascular Hospitalization in Diabetic Patients on Dialysis
Improved glycemic control based on glycated albumin (GA) and plasma glucose predicted CV-related hospitalizations; GA also predicted CV hospitalization length of stay. HbA1c did not predict cause-specific hospitalizations in dialysis populations (American Journal of Nephrology)
Carotid-Femoral Pulse Wave Velocity & Cerebral White Matter Lesions T2D
PWV was higher among patients with well-controlled type 2 diabetes compared with controls and was independently associated with WMLs. PWV may represent a clinically relevant parameter in the evaluation of cerebrovascular disease risk in type 2 diabetes (Diabetes Care)
Professor calls for urgent support for care home ‘silent minority’
A leading diabetes expert has called for urgent support for the ‘silent minority’ in care homes to avoid unnecessary suffering and even premature deaths (Institute of Diabetes for Older People)
The cost of T1D in the UK: a review of cost-of-illness studies
There is no recently published estimate of the cost of Type 1 DM in the UK; therefore, it is recommended that an up-to-date national, comprehensive cost-of-illness study should be conducted. Recommendations for the format of this study are made, including extending the scope to cover recent treatment developments and resource use where diabetes is a subsidiary diagnosis (The European Journal of Health Economics)
COPD and glucose metabolism: a bitter sweet symphony
The current scientific data necessitate a greater outlook on chronic obstructive pulmonary disease and chronic obstructive pulmonary disease may be viewed as a risk factor for the new onset type 2 diabetes mellitus. Conversely, both types of diabetes mellitus should be viewed as strong contributing factors for the development of obstructive lung disease (Cardiovascular Diabetology)
Body Mass Index at Diagnosis of AutoimmuneT1D Children
Youth who are overweight, obese, racial/ethnic minority, and/or present without diabetic ketoacidosis should not be presumed to have type 2 diabetes because many patients with autoantibody-positive T1D present with the same clinical characteristics (The Journal of Pediatrics)
Strategies for Multivessel Revascularization in Diabetes
For patients with diabetes and advanced coronary artery disease, coronary-artery bypass grafting was superior to percutaneous coronary intervention in that it significantly reduced rates of death and myocardial infarction, with a higher rate of stroke (NEJM)
Long-Term Consequences Offspring of Paternal Diabetes
The offspring of parents with diabetes showed higher proportion of variables related to metabolic syndrome compared with those offspring of healthy parents, and this proportion increased in case of diabetic parents plus metabolic syndrome (Experimental Diabetes Research)
Plasma Exposure Insulin Glargine and Metabolites – Subcutaneous Injection
After subcutaneous injection of glargine in male subjects with type 1 diabetes, exposure to glargine is marginal, if any, even at supratherapeutic doses. Glargine is rapidly and nearly completely processed to M1 (21A-Gly-human insulin), which mediates the metabolic effect of injected glargine (Diabetes Care)
Diabetes Death Rates Youths Aged 19 Years and under USA 1968–2009
The trends for diabetes death rates for youths aged
Dipeptidyl Peptidase 4 Inhibition may facilitate healing chronic foot ulcers
We have showed that DPP-4 inhibition accelerates healing of diabetic chronic ulcer, through induction of a histologic pattern consistent with enhanced angiogenesis. To the best of our knowledge, there has been no study evaluating the vildagliptin effect on the healing of foot ulcers in humans (Experimental Diabetes Research)
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