Diabetic retinopathy was diagnosed in about one out of five patients with type 2 diabetes during the first year after diabetes diagnosis in UK general practices. Age, male sex, hyperglycaemia and hypertension were identified as risk factors of early retinopathy in type 2 diabetes (Diabetologia)
Diabetes News
Glycosmedia is dedicated to bringing free, non-promotional, editorially independent news to a global audience about developments in diabetes, and is primarily aimed at health professionals.
Effect of T2D on risk of hepatocellular carcinoma in chronic Hep C
T2DM causes an approximately 1.7-fold enhancement in the development of HCC and malignancies other than HCC in HCV-positive patients treated with IFN (Hepatology)
Glycated albumin superior to H1C for severity coronary artery disease T2D
Serum GA level is a better indicator than HbA1c for evaluating the presence and severity of CAD and predicting major adverse cardiac events in patients with T2DM (Cardiology)
Identification of Serum Metabolites Associated With Risk of T2D
The data indicate that metabolic alterations, including sugar metabolites, amino acids, and choline-containing phospholipids, are associated early on with a higher risk of T2D (Diabetes)
Gestational diabetes: The public health relevance and approach
A great understanding of the importance of GDM and its consequences by the Government and public will go a long way in containing the epidemic of diabetes (Diabetes Research and Clinical Practice)
Setting research priorities for Type 1 diabetes
We have shown that it is possible using the James Lind Alliance process to develop an agreed top 10 list of research priorities for Type 1 diabetes from health professionals, patients and carers (Diabetic Medicine)
Mitochondrial exchanger upregulates glucose dependent ca2+ signalling
These findings suggest that the mitochondrial Na+/Ca2+ exchanger, NCLX, shapes glucose-dependent mitochondrial and cytosolic Ca2+ signals thereby regulating the temporal pattern of insulin secretion in ß cells (PLoS ONE)
Use of Thiazolidinediones & Risk of Colorectal Cancer
A nationwide, population-based, case-control study found that the use of TZDs may be associated with a decreased risk of colorectal cancer in patients with diabetes (Diabetes Care)
Boston Therapeutics Wins FDA Approval for PAZAMET
In addition, the FDA has ruled that no further clinical investigation is necessary to demonstrate the safety and effectiveness of this proposed product (Boston Therapeutics)
Outpatient electronic health records and clinical care and outcomes
Use of a commercially available certified EHR was associated with improved drug treatment intensification, monitoring, and physiologic control among patients with diabetes, with greater improvements among patients with worse control and less testing in patients already meeting guideline-recommended glycemic and lipid targets (Annals of Internal Medicine)
Association between liver insulin resistance & cardiovascular risk factors
Liver IR index correlated more strongly than Matsuda ISI with levels of total cholesterol, CRP and triglycerides. Therefore, liver IR might be a significant indicator of CVD risk amongst men (Journal of Internal Medicine)
Moderate-intensity physical activity ameliorates breast cancer risk
Moderate-intensity physical activity can substantially ameliorate the increased BC risk in diabetic women (Diabetes Care)
Screening for type 2 diabetes doesn’t affect mortality at 10 years
Screening middle aged people for type 2 diabetes has no overall effect on the number who die over the next 10 years, concludes a study by the UK Medical Research Council (BMJ)
Starting injectable treatment in adults with Type 2 diabetes: RCN guidance
This new edition provides information relating to GLP 1 therapy action, including the implications for use and the aspects of education that need to be addressed with users. This guidance is intended for nurses new to insulin therapy, and includes an overview of the underlying principles for starting insulin along with practical tips on education, adjustment of doses, and dealing with difficult situations (RCN)
Outcomes Data for Investigational Novel Basal Insulin Analogue
The study results showed that in addition to clinical results showing a statistically significant 48 percent baseline adjusted reduction in nocturnal hypoglycaemia compared with insulin glargine patients treated with LY2605541* reported a statistically significant reduction in the anxiety and fear associated with experiencing a hypoglycaemic event based upon the Adult Low Blood Sugar Survey (Lilly)
Studies assess linagliptin treatment in adults with T2D
The new analyses show linagliptin, alone or in combination with other diabetes therapies, lowered hemoglobin A1c (HbA1c or A1C) in elderly patients with type 2 diabetes, as well as in adults with type 2 diabetes with diabetic nephropathy (renal disease).Data from a fourth study found adding linagliptin to a stable dose of basal insulin improved blood glucose control over 52 weeks without an additional risk of hypoglycemia or weight gain compared to placebo (Lilly)
Facilitating children’s contributions in clinic
Findings have implications for facilitating children’s contributions in clinic, understanding how ideas about children are reproduced in clinical settings and supporting clinicians to engage with the capacities and priorities of children living with long-term illness (Diabetic Medicine)
A comparison of cost per case detected of screening strategies T2D
Screening a population using a non-invasive risk stratification tool followed by a screening blood test is the most cost-effective method of screening for diabetes and abnormal glucose tolerance (Diabetes Research and Clinical Practice)
Exploring the understanding of evidence-based concepts in T2D
Participants had a poor understanding of most of the evidence-based concepts in type 2 diabetes that were explored. This disadvantages them in being able to make informed decisions about their health care and actively manage their diabetes (International Journal of General Medicine)
Management of Hyperglycemia, Dyslipidemia, and Albuminuria in Diabetes & CKD
Intensive glycemic control and lipid interventions did not improve clinical outcomes in patients with type 2 diabetes (American Journal of Kidney Diseases)
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