These data suggest that, even for patients with long-term DM, renal biopsy should be carried out in patients with presumed DN. Because treatment options differ between DN and primary glomerulopathies, renal biopsy should especially be considered for presumed DN without DR (Journal of Diabetes Investigation)
Diabetes News
Glycosmedia is dedicated to bringing free, non-promotional, editorially independent news to a global audience about developments in diabetes, and is primarily aimed at health professionals.
Efficacy and safety of linagliptin in T2D with poor glycemic control
Linagliptin was an effective, well-tolerated treatment in subjects with T2DM and insufficient glycemic control, both as monotherapy or added-on to metformin/metformin plus sulfonylurea (Journal of Diabetes and Its Complications)
Mortality & Diabetes-Related Outcomes Insulin v Other Antihyperglycemics
Conclusions: In people with T2DM, exogenous insulin therapy was associated with an increased risk of diabetes-related complications, cancer, and all-cause mortality. Differences in baseline characteristics between treatment groups should be considered when interpreting these results (The Journal of Clinical Endocrinology & Metabolism)
Clinical and socio-demographic factors associated with ketoacidosis
This study identifies specific clinical factors associated with diabetic ketoacidosis hospitalization in adults with Type 1 diabetes. This information can help to inform the detection of high-risk patients, for whom special attention and interventions may be warranted to prevent diabetic ketoacidosis (Diabetic Medicine)
Implications of new European Union driving regulations T1D
More than one episode of severe hypoglycaemia within a year was a frequent event in subjects in the Diabetes Control and Complications Trial, especially in intensively treated patients. If applied to current practice, improving road safety through these changes to European Union regulations could have a substantial impact on drivers who have Type 1 diabetes. This emphasizes the need to take into account the potential effects of severe hypoglycaemia in those who rely on a driving licence (Diabetic Medicine)
Blood ß-hydroxybutyrate vs. urine acetoacetate testing for ketoacidosis
There is evidence suggesting that blood ß-hydroxybutyrate testing is more effective than urine acetoacetate testing in reducing emergency department assessment, hospitalization and time to recovery from diabetic ketoacidosis, as well as potentially lowering healthcare expenditure. Further research in both young people and adults is needed (Diabetic Medicine)
Screening for Diabetes & Prediabetes Should be Cost-Saving
From a health economics perspective, screening for diabetes and high-risk prediabetes should target patients at higher risk, particularly those with BMI >35 kg/m2, systolic blood pressure =130 mmHg, or age older than 55 years, for whom screening can be most cost-saving. GCTpl is generally the least expensive test in high-risk groups and should be considered for routine use as an opportunistic screen in these groups (Diabetes Care)
Study of the SGLT2 Inhibitor Empagliflozin in T2D
In patients with type 2 diabetes, empagliflozin resulted in dose-dependent, clinically meaningful reductions in HbA1c and FPG, and reductions in body weight compared with placebo. Empagliflozin was well-tolerated with a favourable safety profile (Diabetes, Obesity and Metabolism)
Observational Study of Once-Daily Insulin Detemir T2D Aged 75 & over
In both the older and younger age groups, the addition of once-daily insulin detemir to existing OAD regimens was effective and safe. In older patients, an improvement in HbA1c of 1.2 % was not associated with an increased risk of severe hypoglycaemia or weight gain (Drugs and Aging)
In-patient diabetes treatment satisfaction in the UK – DIPSat study
The DIPSat programme describes the complex relationships between diabetes in-patient treatment satisfaction and in-patient diabetes care (Diabetic Medicine)
HbA1c and educational level & risk of CV events in T2D
Our results lend support to the recent American Diabetes Association/ European Association for the Study of Diabetes position statement that emphasizes the importance of additional factors, including the propensity for hypoglycaemia, which should influence HbA1c targets and treatment choices for individual patients (Diabetic Medicine)
Family history of T1D affects insulin secretion in T2D
A family history for both type 1 and type 2 diabetes was associated with higher prevalence of GAD antibodies and HLA-DQB1 risk genotypes than a family history of type 2 diabetes only, and was associated with earlier and more severe development of insulin deficiency, which was only partially explained by GAD antibodies and HLA (Diabetic Medicine)
Renal Hemodynamic Alteration in Early Childhood DM
These findings imply that renal ischemia has already developed in both types of early stage childhood DM and GFR is overestimated in DM, which may mislead to improper interpretation of renal function (Renal Failure)
Once-Daily Lyxumia ® (lixisenatide) Approved for Treatment of T2D in EU
Sanofi portfolio expands to offer first once-a-day prandial GLP-1 receptor agonist (Sanofi)
Metabolic syndrome, diabetes, and hyperuricemia
We found evidence to suggest that insulin resistance plays a potentially key role in the causal relationship between metabolic syndrome, type 2 diabetes and hyperuricemia. Furthermore, it is likely that hyperuricemia and insulin resistance share a bidirectional causal effect (Current Opinion in Rheumatology)
Diet quality associated incident impaired fasting glucose in elderly
Greater compliance with published dietary guidelines (better diet quality) was associated with a reduced risk of pre-diabetes in men, but not women (Diabetic Medicine)
Prepregnancy Dietary Protein Intake & Risk of GDM
Higher intake of animal protein, in particular red meat, was significantly associated with a greater risk of GDM. By contrast, higher intake of vegetable protein, specifically nuts, was associated with a significantly lower risk. Substitution of vegetable protein for animal protein, as well as substitution of some healthy protein sources for red meat, was associated with a lower risk of GDM. (Diabetes Care)
Global Remodeling the Vascular Stem Cell Niche in Bone Marrow
We provide new anatomic and molecular evidence for the damaging effect of diabetes mellitus on human BM, comprising microvascular rarefaction and shortage of PCs attributable to activation of proapoptotic pathway (Circulation Research)
NICE unable to recommend dapagliflozin for type 2 diabetes
NICE is minded not to recommend dapagliflozin (Forxiga, Brstol-Myers Squibb and Astra Zeneca) in combination therapy for treating type 2 diabetes. NICE is requesting further clarification and information from the manufacturers ahead of the second Appraisal Committee meeting in March (NICE)
Lixisenatide v liraglutide daily T2D insufficiently controlled metformin
Once daily pre-breakfast lixisenatide provided a significantly greater reduction in PPG (AUC) during a morning test meal versus pre-breakfast liraglutide. Lixisenatide provided significant decreases in postprandial insulin, C-peptide (vs an increase with liraglutide), and glucagon, and better gastrointestinal tolerability than liraglutide (Diabetes, Obesity and Metabolism)
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