This is the first prospective study demonstrating diminished EPCs in children with T1DM. The association of better glycemic control with an increase in EPC numbers within 1 year suggests that a reduction of the high cardiovascular disease burden might be mediated likewise (Diabetes Care)
Diabetes News
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New clinical study with Diamyd’s diabetes vaccine
Diamyd Medical AB reports that a new clinical study with the diabetes vaccine Diamyd® is planned to start in February 2013. In the study Diamyd® will be tested in a unique combination with other drugs, aiming to potentiate the effect of the diabetes vaccine (Diamyd Medical)
Insulin deficiency and resistance to the development of T2D
We examined insulin secretion impairment and insulin resistance in overweight patients with T2D who had metformin failure, with elevated HbA1c at maximal metformin dose (Acta Diabetologica)
Chronic kidney disease & sodium-glucose cotransporter 2 inhibitionT2D
Although absolute glycosuria decreases with declining GFR, the efficiency of ipragliflozin action (fractional glucose excretion) is maintained in patients with severe renal impairment (Diabetes Care)
Changes in red blood cell membrane structure in T2D
We show that the combined AFM and SEM analyses of RBCs give valuable information about the disease status of patients with diabetes. Effectiveness of treatment regimes on the integrity, cell shape and roughness of RBCs may be tracked, as this cell’s health status is crucial to the overall wellness of the diabetic patient (Cardiovascular Diabetology)
Reduced glyoxalase 1 activity & painful peripheral diabetic neuropathy
Our results demonstrate for the first time that Glo1 activity is lower in patients with both types of diabetes mellitus who were diagnosed with painful DN. These data support the hypothesis that Glo1 activity modulates the phenotype of DN and warrant further investigation into the role of Glo1 in DN (Diabetes and Its Complications)
Safety, tolerability, pharmacokinetics, pharmacodynamics empagliflozin
Oral administration of empagliflozin at doses of 10 mg, 25 mg or 100 mg once daily over 28 days resulted in significant increases in UGE and reductions in blood glucose compared with placebo, and were well tolerated in patients with type 2 diabetes (Diabetes, Obesity and Metabolism)
The Efficacy and Safety of Insulin Degludec
The use of extreme dosing intervals of 8–40 h demonstrates that the daily injection time of IDeg can be varied without compromising glycemic control or safety (Diabetes Care)
Diabetes in care homes: a controlled trial of resident education
The intervention improved patient-centred outcomes, with a small effect on glycaemic control. More research needs to be performed with care home residents to develop the evidence base for appropriate interventions in this neglected group of patients (British Journal of Diabetes & Vascular Disease)
Intensification of diabetes medication and risk for 30-day readmission
Among patients with elevated HbA1c, glucose therapy intensification was associated with a decreased 30-day readmission/emergency department admission risk and lower outpatient HbA1c levels (Diabetic Medicine)
Insulin what next?
All subjects with type 1 diabetes need insulin and, given the current lack of disease-modifying drugs, all patients with type 2 diabetes will eventually need insulin if they live long lives. The data supporting the use of the new ‘ultra-long’ acting insulin analogue degludec which are currently being considered by the regulatory authorities show a continued improvement in duration and variability of action but the well-known downsides of weight-gain and hypoglycaemia (albeit diminished) remain. So, what next for insulin?
Trabecular Bone Score and Diabetes-Related Fracture Risk
Lumbar spine TBS predicts osteoporotic fractures in those with diabetes, and captures a larger portion of the diabetes-associated fracture risk than BMD(Journal of Clinical Endocrinology & Metabolism)
Lipoprotein lipase links vitamin D, insulin resistance and T2D
LPL is associated with serum 25(OH)D, IR and T2D in the Chinese population. These results suggest a potential mediating role of LPL in the associations of 25(OH)D with IR and T2D (Cardiovascular Diabetology)
Glycaemic variability in paediatric T1D on CSI or MDI
Paediatric patients with type 1 diabetes using an insulin pump presented with lower glycaemic variability and a concomitantly lower glycaemic risk parameter compared to those using MDII (Clinical Endocrinology)
Circulating cytokine levels, DM and IR in a population-based sample
We found that subjects with diabetes, metabolic syndrome and increased insulin resistance had increased levels of IL6, TNF-a and hs-CRP, while no association was found with IL-1ß. (Clinical Endocrinology)
Electroencephalographic changes in relation to major depressive disorder
In this review we will discuss EEG abnormalities in DM, as well as the biological mechanisms underlying various EEG parameters, in order to evaluate whether or not a common EEG biosignature exists between DM and major depressive disorder ( Neuropsychiatric Disease and Treatment)
Identifying challenges of living with T1D: child and youth perspectives
It is important for nurses to discuss challenges, understand perspectives of this age group, listen to their concerns, work with them to develop strategies promoting health, minimise complications, reduce or eliminate feeling different or alone and assist parents’ efforts to be supportive (Journal of Clinical Nursing)
Plasma YKL-40 Predicts 10-Year CV and All-cause Mortality T2D
Plasma YKL-40 concentration is an independent predictor of 10-year all-cause and cardiovascular mortality in subjects with type 2 diabetes. Further investigations on the role of YKL-40 in the pathogenesis of CVD are required to elucidate the underlying mechanisms (Clinical Endocrinology)
Vascular Outcomes -Screen-Detected or Clinically Diagnosed T2D
Opportunistic targeted screening for type 2 diabetes detected patients with higher CVD morbidity at baseline when compared with clinical diagnosis but showed similar CVD mortality and major CVD morbidity after 7.7 years. Opportunistic targeted screening and guided care appears to improve vascular outcomes in type 2 diabetes in primary care (Annals of Family Medicine)
Evaluation of a Self-Administered Oral Glucose Tolerance Test
Self-administered OGTTs can be performed successfully by untrained individuals in a community setting. With improved device reliability and appropriate calibration, this novel technology could be used in routine practice to screen people who might need a formal OGTT to confirm the presence of impaired glucose tolerance or diabetes (Diabetes Care)
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