Individuals with lower serum 25(OH)D concentrations had higher risk of insulin-requiring diabetes than those with higher concentrations (Diabetologia)
Diabetes News
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Systolic and diastolic blood pressure and all cause mortality T2D
Blood pressure below 130/80 mm Hg was not associated with reduced risk of all cause mortality in patients with newly diagnosed diabetes, with or without known cardiovascular disease. Low blood pressure, particularly below 110/75 mm Hg, was associated with an increased risk for poor outcomes (British Medical Journal)
Liraglutide in T2D controlled on metformin improves vascular function markers
In patients with Type 2 diabetes, well controlled with metformin monotherapy, addition of liraglutide improves several cardiovascular risk markers beyond glycaemic control (Diabetic Medicine)
New data for Novartis drug Lucentis® confirms long-term efficacy and safety
New data for Lucentis® (ranibizumab), the only anti-VEGF therapy licensed across three ocular indications, show that individualized treatment with Lucentis provides sustained improvement in vision with a low number of injections. It is estimated that over 80% of visual impairment is preventable when due to conditions such as … diabetic macular edema (DME)
Representativeness of patients in a web-based adverse drug reaction monitoring
This study shows that diabetes patients participating in a web-based intensive monitoring system differ from a reference population. The observed differences might lead to an underestimation of adverse drug reactions (ADRs), but it is not clear whether this would also influence the type or time-course of the reported ADRs (Pharmacoepidemiology and Drug Safety)
Strategy combining minor genetic susceptibility genes to improve prediction T2D
Genotyping at multiple susceptibility loci in children from affected families can identify neonates with sufficient genetic risk of type 1 diabetes to be considered for early intervention (Genes and Immunity)
Risk Factor, Age and Sex Differences in Chronic Kidney Disease
Women with diabetes had an increased prevalence of advanced DKD and common DKD risk factors compared to men and these disparities were most prominent amongst the elderly (American Journal of Nephrology)
HbA1c variability is associated with microalbuminuria in T2D a 7-year study
In addition to mean HbA1c values, HbA1c variability, even measured as early as 2 years, is independently associated with the development of microalbuminuria in patients with type 2 diabetes (Diabetologia)
Lilly Launches Mobile Application to Support People with Type 1 Diabetes
App serves as a teaching tool and can provide guidance for treatment with Lilly Glucagon for Injection (rDNA origin) during severe hypoglycemic events (Lilly)
Vascular Disease in Diabetic Women: Why Do They Miss the Female Protection?
This review calls attention to the lack in knowledge, understanding, and general awareness of medical and scientific societies on how to treat and prevent diabetic vascular disease in women. Despite the evident gender-associated differences in the phathophysiology of CVD and the higher incidence of vascular disease in diabetic women, the trends and guidelines are dominated by data obtained in men (Experimental Diabetes Research)
One in Ten Campaign 2012
Diabetes UK Cymru has joined forces with the Stoke Association, Public Health Wales, Community Pharmacy Wales and all seven health boards to launch a major public health campaign in September (Diabetes UK Cymru )
Diabetology – A new sponsor of Glycosmedia
A big thank you to Diabetology for sponsoring Glycosmedia
Their logo (along with Lilly’s) will be joining Abbott on our App shortly (next update).
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Glycosmedia is a diabetes clinical review that displays a selection of the very latest research papers, reports, news and information about diabetes
IR in tissues with long term continuous subcutaneous insulin infusion therapy
Insulin resistance is a prominent feature of lean patients with type 1 diabetes mellitus, despite long term and stable treatment with CSII. Insulin resistance in type 1 diabetes involves both lipolysis, hepatic and peripheral glucose metabolism (Diabetes/Metabolism Research and Reviews)
Impact of community pharmacy diabetes monitoring and education programme
Education and counselling by community pharmacists can result in favourable improvements to the cardiovascular risk profile of patients with Type 2 diabetes (Diabetic Medicine)
Quality of T2D management associated with involvement of general practice nurses
Compared with practices with no nurse(s) employed, the quality of diabetes management was generally higher in terms of that HbA1c was measured according to the guidelines in a larger proportion of the diabetes population and the proportion of patients with an HbA1c level =8% was lower in practices with well-implemented nurse-led type 2 diabetes consultations (Primary Care Diabetes)
Serum vitamin D levels are lower in Australian children with t1D
Children with T1DM have lower 25OHD than controls, even in an environment of abundant sunlight. Whether low vitamin D is a risk factor or consequence of T1DM is unknown (Pediatric Diabetes)
Blood Glucose Control in Type 1 Diabetes With a Bihormonal Bionic Endocrine Pancreas
A bihormonal bionic endocrine pancreas achieved excellent glycemic control with minimal hypoglycemia over the course of 2 days of continuous use despite high-carbohydrate meals and exercise. A trial testing a wearable version of the system under free-living conditions is justified (Diabetes Care)
Genes for type 2 diabetes are they worth it?
A recent publication reported the identification of another ten genes which may predispose to type 2 diabetes (T2DM), bringing the current total to around fifty. However, the impact of these genetic studies from a clinical perspective remains minimal. Forty years after the discovery of the first genes involved in diabetes susceptibility, should we be querying the value of expensive ‘factory floor’ genetics?
Factors That Influence Parental Attitudes toward Enrollment in Type 1 Diabetes Trials
Parents report moderate willingness to enroll children in T1DCTs. Willingness is diminished by common trial methodologies. Although most parents recalled receiving trial-related information, significantly fewer recalled being asked to participate. Efforts to optimize effective communication around identified areas of parental concern may increase T1DCT participation (PLoS ONE)
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