Our findings showed a high prevalence of unawareness of having clinical DSPN among the prediabetic and diabetic groups and an insufficient frequency of professional foot examinations, suggesting inadequate attention to diabetic foot prevention practice (Diabetes Care)
Diabetes News
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Biguanides suppress hepatic glucagon signalling decrease cyclic AMP
A novel mechanism by which metformin antagonizes the action of glucagon, thus reducing fasting glucose levels (Nature)
Diabetes Prevention Program interventions and cardiovascular risk
Overall, intensive lifestyle intervention achieved, with less medication, a comparable long-term effect on cardiovascular disease risk factors, to that seen in the metformin and placebo groups. (Diabetic Medicine)
Intensive blood pressure control in obese patients – ACCORD trial
In the ACCORD clinical trial, lowering blood pressure (BP) to normal levels, below currently recommended levels, did not significantly reduce the combined risk of fatal or nonfatal cardiovascular (CV) disease events in adults with Type 2 diabetes (Expert Review of Cardiovascular Therapy)
What should be the antihypertensive drug of choice in diabetic patients
Should we avoid drugs that increase glucose levels? Pro and Cons (Diabetes/Metabolism Research and Reviews)
Association of an Intensive Lifestyle Intervention & Remission T2D
In these exploratory analyses of overweight adults, an intensive lifestyle intervention was associated with a greater likelihood of partial remission of type 2 diabetes compared with diabetes support and education. However, the absolute remission rates were modest (JAMA)
Management of raised glucose, a clinical decision tool
The management of raised glucose clinical decision tool resulted in a significant increase in the number of same-calendar-day discharges and reduction in hospital length of stay without adverse impact on readmission rates. Additionally, the tool was associated with improvements in inpatient diabetes care and patient satisfaction (Diabetic Medicine)
First-trimester screening porgram for gestational DM
These results suggest that differences can be seen between diabetic and healthy pregnant women in first-trimester maternal serum biochemical markers of aneuploidy (Gynecological Endocrinology)
5HT2A & 5HT2B Receptors & Serotonin-Induced Vascular Dysfunction
The present study demonstrates that the augmented contractions of arteries in a model of type 2 diabetes are primarily due to changes in signaling pathways within smooth muscle that regulate calcium sensitivity of contractile proteins rather than a change in endothelial-derived vasoactive factors or specific serotonin receptor subtypes (Experimental Diabetes Research)
Heterogeneity lipids & HbA1c undermines plausibility metabolic syndrome
LDL-cholesterol and triglycerides worsened alongside HbA1c with distinct thresholds. Association of lower HDL-cholesterol with higher daily insulin dose is consistent and it point out to a role of exogenous hyperinsulinemia in the pathophysiology of the CVRF clustering. These data suggest diverse pathophysiological processes depending on HbA1c, refuting a unified explanation for cardiovascular risk in type 1 diabetes (Cardiovascular Diabetology)
The p53 codon 72 polymorphism and the degree of insulin resistance T2D
Our findings suggest that p53 codon 72 (Arg72Pro) polymorphism influences insulin resistance in type 2 diabetic patients independently of body mass (Acta Diabetologica)
Intraepidermal nerve fiber density, conduction & staging polyneuropathy
Clinical staging for DP by DNSGJ reflects the results of small and large fiber neuropathy (Diabetes Research and Clinical Practice)
Population based screening ¬& prevention of lower extremity complications
The evidence base for formal national primary care based foot screening of all patients with diabetes is weak. Focused research is needed to confirm that general population based screening in the community is effective and cost-effective (Diabetes/Metabolism Research and Reviews)
Ultrastructural morphometric analysis of insulin secretory granules T2D
The volume density of insulin granules significantly (p
Impact of self-treated hypoglycaemia in T2D
Self-treated hypoglycaemia is common in approximately one third of patients using insulin analogue regimens. Additionally, self-treated hypoglycaemia was found to be associated with clinically significant effects on patient well-being and functioning, patient and physician management and healthcare utilisation (Current Medical Research and Opinion)
Linguistic & Psychometric Validation of Diabetes Quality-of-Life Scale UK
The DSQOLS captures the impact of detailed aspects of modern type 1 diabetes management (e.g., carbohydrate counting and flexible insulin dose adjustment) that are now routine in many parts of the U.K. and Ireland. The U.K. English version of the DSQOLS offers a valuable tool for assessing the impact of treatment approaches on QoL in adults with type 1 diabetes (Diabetes Care)
Alcohol consumption is associated with reduced risk of T2D
Moderate alcohol consumption associates with reduced risk of both Type 2 diabetes and autoimmune diabetes. A protective effect of alcohol intake may be limited to men. High alcohol consumption does not seem to carry an increased risk of diabetes (Diabetic Medicine)
Changes in serum phosphate during treatment of diabetic ketoacidosis
The severity of subsequent hypophosphataemia can be predicted by the degree of metabolic acidosis on presentation. As profound hypophosphataemia can be associated with serious complications, clinicians should recognise the likelihood of this biochemical derangement in those DKA patients presenting with profound acidosis (Internal Medicine Journal)
Nutritional determinants of worldwide diabetes – food markets
Current diabetes projection methods may estimate future diabetes rates poorly if they fail to incorporate the impact of nutritional factors. Imported sugars deserve further investigation as a potential population-level driver of global diabetes (Public Health Nutrition)
Ideal v real conditions T2D care: diabetes specialty nurses’ perspectives
The participants expressed that they were the “hub” of diabetes care, but they were subordinated by the physicians. In order to achieve “good” diabetes care, GPs and nurses should collaborate more to try to understand each other´s areas of responsibility in order to improve the diabetes care (Internet Journal of Advanced Nursing Practice)
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