A global measure of stress may not accurately account for the association between perceived stress and metabolic control. FS, rather than IP stress seems to be a key stress domain linked to suboptimal metabolic control(Journal of Paediatric Psychology)
Diabetes News
Glycosmedia is dedicated to bringing free, non-promotional, editorially independent news to a global audience about developments in diabetes, and is primarily aimed at health professionals.
Determinants of Insulin Resistance in Infants at Age 1 Year – Impact of gestational diabetes mellitus
In the 1st year of life, weight gain in infants born to women with GDM is associated with insulin resistance, unlike in their peers (Diabetes Care)
Health Care Transition in Patients With Type 1 Diabetes – Young adult experiences and relationship to glycemic control
Contemporary transition practices may help prevent gaps between pediatric and adult care but do not appear to promote improvements in A1C. More robust preparation strategies and handoffs between pediatric and adult care should be evaluated (Diabetes Care)
Quality of guidelines on the management of diabetes in pregnancy: a systematic review
The quality of most guidelines concerning the management of diabetes during pregnancy needs to be improved. A more systematic approach in the development of these guidelines, more attention for updating procedures and piloting of the guidelines and involvement of target users and patients is recommended (BMC Pregnancy and Childbirth)
Effect of screening for Type 2 diabetes on population-level self-rated health outcomes and measures of cardiovascular risk: 13-year follow-up of the Ely cohort
Screening for diabetes is not associated with long-term harms at the population level. However, screening has limited long-term impact on those testing negative; benefits may largely be restricted to those whose diabetes is detected early through screening (Diabetic Medicine)
Vitamin D and gestational diabetes: A systematic review and meta-analysis
This meta-analysis indicates a significant inverse relation of serum 25OHD and the incidence of GDM. However, it remains unclear whether this association is causal due to the observational study design of the studies (European Journal of Internal Medicine)
The Effect of Type 2 Diabetes Risk Loci on Insulin Requirements in Type 1 Diabetes
We identified two T2D susceptibility loci that modulate insulin requirements in T1D patients. Our results are consistent with the association of lower insulin secretion with higher insulin sensitivity. To explain the continuation of this correlation after ß-cell destruction, we hypothesize an epigenetic mechanism that alters insulin responsiveness in T1D patients based on ß-cell function in early life (Hormone Research in Paediatrics)
Mechanisms Involved in the Development and Healing of Diabetic Foot Ulceration
Increased inflammation, expression of MMP-9, PTP1B, and aberrant growth factor levels are the main factors associated with failure to heal DFUs. Targeting these factors may prove helpful in the management of DFUs (Diabetes)
Early Loss of the Glucagon Response to Hypoglycemia in Adolescents With Type 1 Diabetes
The glucagon response to hypoglycemia in adolescents with type 1 diabetes is influenced by the duration of diabetes and can be lost early in the course of the disease (Diabetes Care)
The pathogenic role of the renal proximal tubular cell in diabetic nephropathy
In this review, we offer a critical appraisal of the events linking the participation of the proximal tubular epithelial cell (PTEC) to the pathogenesis of DN, which we believe may be collectively termed diabetic tubulopathy (Nephrology Dialysis Transplantation)
Personal continuous glucose monitoring (CGM) in diabetes management
Review of the literature and implementation for practical use … Efficacy of CGM systems is now proven but indications, terms of use and educational issues of this new technology still need to be specified (Diabetes Research and Clinical Practice)
IDF’s Diabetes and Climate Change Report
Diabetes and climate change are two urgent challenges in the 21st century. IDF has produced a pioneering policy report that establishes both the interconnections between these global risks and the opportunity to combat them together (International Diabetes Federation)
Association of Prediabetes and Diabetes With Stroke Symptoms
The REasons for Geographic And Racial Differences in Stroke (REGARDS) study – In this population-based study, almost one in four individuals with diabetes reported stroke symptoms, which suggests that screening for stroke symptoms in diabetes may be warranted (Diabetes Care)
Comparison of the effects of different statins and doses on lipid levels in patients with diabetes: Results from VOYAGER
This meta-analysis of 8859 patients with diabetes mellitus shows favourable effects on lipids with the three statins studied, in line with results for the overall VOYAGER population. The importance of using an effective statin at an effective dose to reach treatment goals for such high-risk patients is evident (Nutrition, Metabolism & Cardiovascular Diseases)
Female reproduction and type 1 diabetes: from mechanisms to clinical findings
Despite improvements in insulin therapy, T1D patients still suffer many reproductive problems that warrant specific diagnoses and therapeutic management. Similar to other states of metabolic stress, T1D represents a challenge to the correct functioning of the reproductive axis (Human Reproduction Update)
Management of hyperglycaemia in type 2 diabetes: a patient-centered approach
Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
Ramp up diabetes treatment after three months, GPs told
GPs are being urged to ramp up diabetes treatment within just three months if they do not reach their glycaemic goals on metformin alone, under a radical update of guidelines issued by European and American diabetes societies (Pulse)
Randomized control trial of topical clonidine for treatment of painful diabetic neuropathy
Topical clonidine gel significantly reduces the level of foot pain in painful diabetic neuropathy subjects with functional (and possibly sensitized) nociceptors in the affected skin as revealed by testing with topical capsaicin. Screening for cutaneous nociceptor function may help distinguish candidates for topical therapy for neuropathic pain (International Association for the Study of Pain)
Postprandial Platelet Activation
Our results suggest that postprandial insulin rather than glucose accounts for postprandial platelet activation in T2DM patients (Diabetes)
Does Insulin Resistance Drive the Association between Hyperglycemia and Cardiovascular Risk?
The association between plasma glucose levels and CVD risk is mainly explained by insulin resistance, which raises the question of whether glucose lowering per se without changes in the processes that underlie hyperglycemia should be the sole clinical paradigm in the treatment of type 2 diabetes or its prevention (PLoS ONE)
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