Pre-diabetes, defined as impaired glucose tolerance or a combination of impaired fasting glucose and impaired glucose tolerance, may be associated with a higher future risk of stroke, but the relative risks are modest and may reflect underlying confounding (BMJ)
Diabetes News
Glycosmedia is dedicated to bringing free, non-promotional, editorially independent news to a global audience about developments in diabetes, and is primarily aimed at health professionals.
The 2010-2011 National Diabetes Audit
Report on care processes and treatment targets in England and Wales (NHS)
JDRF and Novo Nordisk establish R&D collaboration in type 1 diabetes
To address the underlying autoimmune process that is central to type 1 diabetes (T1D), JDRF and Novo Nordisk are partnering to discover and develop novel immunotherapies to prevent, treat, and help cure the disease (World Pharma News)
Activation of EGFR/ERBB2 via Pathways Involving ERK1/2, P38 MAPK, AKT and FOXO Enhances Recovery of Diabetic Hearts from Ischemia-Reperfusion Injury
These findings may have clinical relevance particularly in the treatment of diabetes-induced cardiac dysfunction (PLoS ONE)
A Clinical Trial to Maintain Glycemic Control in Youth with Type 2 Diabetes
Monotherapy with metformin was associated with durable glycemic control in approximately half of children and adolescents with type 2 diabetes. The addition of rosiglitazone, but not an intensive lifestyle intervention, was superior to metformin alone (NEJM)
HbA1c Measured in Stored Erythrocytes Is Positively Linearly Associated with Mortality in Individuals with Diabetes Mellitus
This prospective study showed that persons with lower HbA1c had better survival than those with higher HbA1c. The association was linear and independent of disease duration, type of medication use, and presence of co-morbidities. Any improvement of HbA1c appears to be associated with reduced mortality risk (PLoS ONE)
NICE launches BNF prescription drug app
The new app is called NICE BNF and has been developed to provide easy access to the latest up-to-date prescribing information from the BNF – the most widely-used medicines information resource within the NHS. The app is available to download for free to health and care professionals via the Apple App Store and Google Play Store. Users will need to enter their NHS Athens user name and password to activate the app and download the content (Hopspital Pharmacy)
Insulin glargine versus sitagliptin in insulin-naive patients with type 2 diabetes mellitus uncontrolled on metformin
Our results support the option of addition of basal insulin in patients with type 2 diabetes inadequately controlled by metformin (The Lancet)
Maternal Hemodynamics at 11–13 Weeks’ Gestation in Gestational Diabetes Mellitus
Women who develop GDM have increased SBPAo and arterial stiffness from the first trimester of pregnancy before the clinical onset of GDM (Fetal Diagnosis and Therapy)
Hemoglobin A1c Versus Oral Glucose Tolerance Test in Postpartum Diabetes Screening
Our results seem to indicate that the A1C test criterion alone or in combination with fasting glucose test criterion does not provide a sensitive and specific diagnosis of abnormal carbohydrate metabolism in women who have had GDM (Diabetes Care)
Prediction of cardiovascular events, diabetic nephropathy, and mortality by albumin concentration in a spot urine sample in patients with type 2 diabetes
Random UAC >=14mg/l predicted cardiovascular events, diabetic nephropathy, and mortality just as well as ACR. UAC may be used to assess cardiovascular and renal risks in patients with type 2 diabetes (Journal of Diabetes and Its Complications)
Trends in childhood type 1 diabetes incidence in Europe during 1989–2008: evidence of non-uniformity over time in rates of increase
The incidence rate of childhood type 1 diabetes continues to rise across Europe by approximately 3–4% per annum, but the increase is not necessarily uniform, with periods of less rapid and more rapid increase in incidence occurring in many registers. Our findings suggest that important environmental risk exposures are changing over time in different ways across European countries (Acta Diabetologica)
A discovery-phase urine proteomics investigation in type 1 diabetes
This study gives new insights on potential molecular mechanisms associated with the complications of type 1 diabetic disease providing evidences of urine proteins potentially exploitable as putative prognostic biomarkers (Acta Diabetologica)
Toenail Selenium and Incidence of Type 2 Diabetes Mellitus in U.S. Men and Women
At dietary levels of intake, individuals with higher toenail Se levels are at lower risk for T2DM (Diabetes Care)
Effect of regression from prediabetes to normal glucose regulation on long-term reduction in diabetes risk – results from the Diabetes Prevention Program Outcomes Study
We conclude that prediabetes is a high-risk state for diabetes, especially in patients who remain with prediabetes despite intensive lifestyle intervention. Reversion to normal glucose regulation, even if transient, is associated with a significantly reduced risk of future diabetes independent of previous treatment group (The Lancet)
C-reactive protein concentration predicts mortality in type 2 diabetes: the Diabetes Heart Study
This study documents the utility of C-reactive protein in predicting risk for all-cause mortality in European Americans with Type 2 diabetes and supports its use as a screening tool in risk prediction models (Diabetic Medicine)
Relation between augmentation index and adiponectin during one-year metformin treatment for nonalcoholic steatohepatosis
Metformin treatment was associated with significant decrease in AI during one year treatment in NAFLD patients. These beneficial vascular effects was associated with exposure to metformin per se as well as change in adiponectin levels suggesting that metformin may mediate its vascular effects via glicemic control-independent mechanisms (Cardiovascular Diabetology)
Assessing diabetes-related quality of life of youth with type 1 diabetes in routine clinical care: the MIND Youth Questionnaire (MY-Q)
The MY-Q is the first HRQoL questionnaire designed for use in clinical care. It has acceptable measurement properties and seems suitable for implementation in routine care of teenagers with diabetes (Pediatric Diabetes)
The effect of ubiquinone in diabetic polyneuropathy: A randomized double-blind placebo-controlled study?
Twelve weeks treatment with ubiquinone improves clinical outcomes and nerve conduction parameters of diabetic polyneuropathy; furthermore, it reduces oxidative stress without significant adverse events (Diabetes and Its Complications)
‘Omics’-driven discoveries in prevention and treatment of type 2 diabetes
Panels of multiple biomarkers reflecting several pre-diabetic pathologies have been developed. Their specificity and potentials for future risk stratification are discussed. The review also explores the perspectives of selected examples within applied genomics and metagenomics for improving patient care by facilitating interventions tailored to specific subpopulations (European Journal of Clinical Investigation)
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